+90-548-875-8000
Sunday, June 15, 2025
en_GB English
en_GB English tr_TR Turkish ru_RU Russian it_IT Italian de_DE German es_ES Spanish ar Arabic fr_FR French
North Cyprus IVF
  • About
    • About North Cyprus IVF Centre
    • IVF Success Rates
    • Our Team
      • North Cyprus IVF Team
      • Assoc. Prof. Dr. Savas Ozyigit
      • Asst. Prof. Dr. Ahmet Ozyigit
      • Asst. Prof. Dr. Idil Aslan
  • Blog
  • Infertility
    • Infertility
    • Female Infertility
    • Male Infertility
    • Testing
    • Treatment Decision
    • IVF Failures
    • Miscarriages
    • Improving Fertility
    • Fertility Treatment Options
  • IVF Treatments
    • New IVF Advances
      • New Advances
      • Prp Treatment
      • Stem Cell Therapy For Azoospermia
      • Advanced Sperm Selection
      • Embryoscope
      • Intralipid Therapy
    • Mitochondrial Replacement Therapy!
    • IVF Treatment in Cyprus
    • IUI
    • Mini IVF
    • IVF + ICSI
    • Cytoplasmic IVF
    • Tandem IVF Cycle
    • Egg Donation
    • Embryo Donation
    • Sperm Donation
    • Gender – Sex Selection
    • Gestational Surrogacy
    • Same Sex Gay Surrogacy
    • Surgical Sperm Retrieval
    • Pre Implantation Genetic Diagnosis PGD
    • Egg Freezing
    • Gender Selection Using Donor Eggs
    • Sickle Cell Disease Prevention
  • F.A.Q.
    • FAQ
    • IVF-ICSI Questions
    • IVF With Donor Eggs
    • IVF With Donor Sperm
    • Gender Sex Selection
    • Surrogacy
    • Microsort Gender Selection
  • Travel
    • Travel
    • IVF Medication
    • Local Consultants For IVF Treatment Abroad
    • First Consultation
    • Accommodation Options
Contact Us
  • About
    • About North Cyprus IVF Centre
    • IVF Success Rates
    • Our Team
      • North Cyprus IVF Team
      • Assoc. Prof. Dr. Savas Ozyigit
      • Asst. Prof. Dr. Ahmet Ozyigit
      • Asst. Prof. Dr. Idil Aslan
  • Blog
  • Infertility
    • Infertility
    • Female Infertility
    • Male Infertility
    • Testing
    • Treatment Decision
    • IVF Failures
    • Miscarriages
    • Improving Fertility
    • Fertility Treatment Options
  • IVF Treatments
    • New IVF Advances
      • New Advances
      • Prp Treatment
      • Stem Cell Therapy For Azoospermia
      • Advanced Sperm Selection
      • Embryoscope
      • Intralipid Therapy
    • Mitochondrial Replacement Therapy!
    • IVF Treatment in Cyprus
    • IUI
    • Mini IVF
    • IVF + ICSI
    • Cytoplasmic IVF
    • Tandem IVF Cycle
    • Egg Donation
    • Embryo Donation
    • Sperm Donation
    • Gender – Sex Selection
    • Gestational Surrogacy
    • Same Sex Gay Surrogacy
    • Surgical Sperm Retrieval
    • Pre Implantation Genetic Diagnosis PGD
    • Egg Freezing
    • Gender Selection Using Donor Eggs
    • Sickle Cell Disease Prevention
  • F.A.Q.
    • FAQ
    • IVF-ICSI Questions
    • IVF With Donor Eggs
    • IVF With Donor Sperm
    • Gender Sex Selection
    • Surrogacy
    • Microsort Gender Selection
  • Travel
    • Travel
    • IVF Medication
    • Local Consultants For IVF Treatment Abroad
    • First Consultation
    • Accommodation Options
No Result
View All Result
North Cyprus IVF

Stem Cell Therapy for Patients Suffering from Non-Obstructive Azoospermia

Asst. Prof. Dr Ahmet Ozyigit, MD by Asst. Prof. Dr Ahmet Ozyigit, MD
01/15/2020 - Updated on 03/22/2020
in Stem Cell Therapy
0 0
8
Stem Cell Therapy for Patients Suffering from Non-Obstructive Azoospermia
6
SHARES
10.8k
VIEWS
Share on FacebookShare on Twitter

Stem Cell Therapy for Sperm Production?

Non-obstructive azoospermia involves a group of problems, which produce a similar outcome: Lack of sperm production/maturation. Spermatogenesis, which is a term used for the sum of all of the processes involved in production and maturation of a sperm cell, has multiple steps. Any malfunction during any of these steps can cause problems in obtaining a mature sperm cell in the ejaculate. These stages can be roughly categorized as Mitosis (making copies of the germ cells), meiosis 1, meiosis 2 and final differentiation. The whole process takes about 65-70 days to complete and results in a mature sperm cell.
​
Depending on the stage where sperm production/maturation comes to a halt is important for determining success with stem cell therapy. Sperm maturation problems could be attributed to intrinsic germ cell defects or extrinsic somatic and/or endocrine problems. Knowing the difference can be the key to identify the precise targeting of the problem. However, such targeted therapy is currently not available in the human model. The following picture helps with visualization of the spermatogenesis process:

Mitosis is the stage where the germ cell line multiples and grows in number. Differentiation comes in during the later stages. For instance, if spermatogenesis can reach the stage where it results in spermatids, then the main issue rests with final differentiation into the sperm cell as we know it. This is probably one of the most suitable cases for stem cell therapy as only one stage in the process of spermatogenesis is problematic and the likelihood of successfully addressing the problem is higher. 

If the problem is in the earlier stages and there are no immature sperm cells being produced, then the task becomes more challenging. Therefore, the further down the process of spermatogenesis we run into problems, the higher the chance of success with any intervention we use.

“Sertoli cell only” syndrome refers to a condition where the testicular structures have nor germ cells and only sertoli cells are present. Sertoli cell only syndrome can be congenital or acquired. In congenital sertoli cell only syndrome, given that there are no germ cells present, there are currently no treatment modalities which can be offered. However, if the condition is acquired (klinefelter syndrome, mumps, radiation exposure to name a few), then the condition can be reversible and stem cell therapy can be administered.

As part of the stem cell therapy at North Cyprus IVF, we isolate stem cells from the patient’s own adipose tissue to be obtained from abdominal liposuction. This is a small-scale surgery, which is performed by a surgeon. Standard surgical procedures apply, which means food and drink restriction to be observed starting at a certain time before the surgery. We also perform a number of tests to confirm suitability for surgery. These are rather standard procedures.

Adipose tissue obtained via the liposuction process is then subjected to enzymal dissociation and several other procedures so that the stem cells can be successfully isolated. In the meanwhile, patient’s platelet rich plasma (PRP) to be obtained from peripheral blood sample is also isolated separately. After the stem cells are subjected to culture media and seeding and once all the procedures are carried out, the combination of PRP with stem cell population is injected into testes at various different locations.

After the procedure, you are discharged from the hospital either on the same day or the next day, depending on recovery process. A semen analysis is required three months after the stem cell therapy to see the effects. In patients with intact spermatogenesis with the problems in later stages, we expect to observe live sperm cells in the ejaculate approximately three months after the procedure. If we do not observe live sperm cells in the ejaculate, a TESE/TESA procedure is scheduled to look for maturing sperm cells which can be used for fertilization. The entire treatment takes about 2-3 days (pre-testing, procedure itself and recovery time). This means you will only be required to stay in Cyprus for 2-3 days in total.

What is the cost of stem cell therapy for Azoospermia?

The cost of this procedure is 6,000 Euros, which includes the pretests before surgery, all the laboratory work involved and injection of the stem cells as well as your stay at the hospital for one night. The tests required before planning your treatment are ideally done in your local country and are not included in this fee.

You will find more information on our “Stem Cell Therapy for Non-Obstructive Azoospermia” page.

Please contact our patient coordinators for more information!

Tags: Stem Cell For Nonobstructive AzoospermiaStem Cell Sperm 2020Stem Cell Therapy For Azoospermia
Previous Post

Spontaneous Intracranial Hypotension Presenting with Frontotemporal Dementia, Narcolepsy and Chorea: A Case Study

Next Post

North Cyprus – The Safest Country in the World During the Covid-19 Pandemic!

Asst. Prof. Dr Ahmet Ozyigit, MD

Asst. Prof. Dr Ahmet Ozyigit, MD

More recently, I have found my passion in health care where I first started off in a managing position and gradually integrated myself into the medical delivery of health care. Despite having a doctoral degree in social sciences, I have decided that being a medical doctor and being able to make a difference in provision of healthcare is something that I would like to do for the rest of my life.

Next Post
North Cyprus – The Safest Country in the World During the Covid-19 Pandemic!

North Cyprus – The Safest Country in the World During the Covid-19 Pandemic!

Comments 8

  1. Joseph says:
    5 years ago

    Good Day,

    I am a diagnosed NOA patient in Australia.

    I have completed two unsuccessful microtese operations. One was completed in April 2019 and the most recent was March 2020.

    Both reports have returned as Sertoli Cell only.

    They have advised the NOA was caused by the chemotherapy that I undertook between 1998 to 1999 for Acute Myloid Leukaemia. I had a successful bone marrow transplant from my sister in April 1999.

    My hormones are still recovering from the operations, but have usually been in normal ranges.

    I have also completed a skin biopsy to check for y chromosome micro deletion which returned normal.

    I would like to know if you have treated any cases like mine? If so what was the outcome?

    Look forward to hearing from you.

    Regards,

  2. Asst. Prof. Dr Ahmet Ozyigit, MD says:
    5 years ago

    Hi,

    We have answered your query via email. Please let us know if there is anything else we can help you with.
    Kind regards,

    NCIVF Team

    Asst. prof. Dr. Ahmet Ozyigit, PhD
    Head of Clinical Research

  3. Sana says:
    5 years ago

    Hi my husband has non-obstructive azoospermia, he had a diagnostic needle biopsy in 2014 where the results said that the tubules show spermatogenesis with all levels of maturation present, however only one or two spermatids present within the central lumen so overall spermatogenesis is reduced in amount. At that time we were not ready for IVF due to the shock of the diagnosis and financial issues. We recently went for IVF and he had a micro TESE, however the Dr extracted 24 tubules and out of those the embryologist was only able to find 12 sperm. She said it was abnormal and she said it was “something that looked like sperm”. Only 2 of my eggs fertilised but they were slow developing embryos and the one that they transferred didnt implant and the other one has a C grade trophectoderm which they froze. I dont believe i have any chances with that embryo. I dont know what went wrong after 6 years as the first result looked promising with evidence of spermatids but the micro Tese results werent so good. The tubules have been sent to histology but we havent gone to see the Dr yet to get the results as we have been depressed. Do you think there is anything you might be able to do to help us? Thank you very much

    • Asst. Prof. Dr Ahmet Ozyigit, MD says:
      5 years ago

      Hi,

      Is it possible to send us the biopsy report along with the IVF treatment details? We would like to have all the details and have our physicians make an assessment so that we can offer you a solution accordingly. Please email us at dr.ahmet@northcyprusivf.com.

      Kind regards,

      Dr. Ahmet Ozyigit, MD, MSc, PhD.
      Clinical Coordinator and Clinical Lead for Research – Elite Hospital
      Assistant Professor- University of Mediterranean Karpasia

  4. Arun Eswaran says:
    5 years ago

    Hello,

    I was diagnosed with non-obstructive azoospermia and i have undergone 1 microtese and 1 bilateral sperm mapping. Both the procedures didn’t show any sperms. The sperm mapping procedure revealed only sertoli cells. Is there any therapy for my condition? Thank you very much!

    • Asst. Prof. Dr Ahmet Ozyigit, MD says:
      5 years ago

      Hello,

      In sertoli cell only syndrome, stem cell injection often fails to achieve desired results for the lack of any germ cells to act as a template, in our experience. However, it would be best to see the biopsy report before commenting further.

      Dr. Ahmet Ozyigit, MD, MSc, PhD.
      Clinical Coordinator and Clinical Lead for Research – Elite Hospital
      Assistant Professor- University of Mediterranean Karpasia

  5. Salma says:
    5 years ago

    Hi
    My husband was diagnosed with NOA and have gone under micro TESE biopsy and pathology test.
    The pathology test showed Sertoli cell-only Syndrome.
    Is there a cure for this?
    I would like also to send the report for the Pathology test result.
    Thank you so much!

    • Asst. Prof. Dr Ahmet Ozyigit, MD says:
      5 years ago

      Dear Salma,

      Please send us the pathology report for a more effective assessment. If the report is conclusive with a sertoli cell only syndrome, it usually suggests that germ cells are not present and the likelihood of success in such cases would be very minimal. However, it would be a good idea to see the biopsy results.

      Dr. Ahmet Ozyigit, MD, MSc, PhD.
      Clinical Coordinator and Clinical Lead for Research – Elite Hospital
      Assistant Professor- University of Mediterranean Karpasia

No Result
View All Result
Dr. Savas Ozyigit

Director & IVF Specialist

Medically Reviewed by Assoc. Prof. Dr. Savas Ozyigit

Recent Posts

  • When is the ideal time for Ovarian PRP Treatment?
  • Endometriosis and Its Impact on Pregnancy Outcomes and IVF Success
  • PCOS: How Does it Affect Pregnancy Outcomes?
  • An IVF Cycle: Taking The First Step
  • NMN and Oocyte Health: Using NMN As a Supplement in IVF Cycles.

Archives

  • November 2024
  • September 2024
  • August 2024
  • June 2024
  • April 2024
  • January 2024
  • November 2023
  • September 2023
  • April 2022
  • October 2021
  • June 2021
  • July 2020
  • June 2020
  • January 2020
  • August 2018
  • May 2017
  • December 2016
  • August 2016
  • July 2016
  • June 2016
  • May 2016
  • February 2016
  • November 2015
  • October 2015
  • August 2015
  • July 2015
  • June 2015

Categories

  • +40 IVF Treatment
  • Egg Donation
  • Gender Selection
  • Infertility Treatment
  • IVF Treatment
  • News
  • Sperm Donation
  • Stem Cell Therapy
  • Uncategorized
Facebook Twitter Instagram Youtube

North Cyprus IVF Centre

North Cyprus IVF Centre is a patient focused fertility clinic, located within “Elite Research and Surgical Hospital” in Nicosia, Cyprus. Our clinic is one of the most advanced fertility clinics in the world, offering a wider selection of treatment options at affordable prices.

Main Links

Infertility Causes
IVF Treatments
New Advances in IVF
IVF Related F.A.Q
About Cyprus IVF Centre
Contact Cyprus IVF Centre

Contact Us

Phone

English:  +90 548 875 8000
French: +90 548 876 8000
Turkish:  +90 542 869 8000
Arabic: +90 548 875 8000
German:  +90 548 830 1987
Russian: +90 548 828 9955

E-Mail

info@northcyprusivf.net

© 2020 LowCostIVF - All rights reserved. Privacy Policy

No Result
View All Result
  • Home
  • Contact
  • Infertility
    • Infertility
    • Female Infertility
    • Male Infertility
    • Testing
    • Treatment Decision
    • IVF Failures
    • Miscarriages
    • Improving Fertility
    • Fertility Treatment Options
  • IVF Treatments
    • IVF Treatment in Cyprus
    • Mitochondrial Replacement Therapy
    • IUI
    • Mini IVF
    • IVF + ICSI
    • Cytoplasmic IVF
    • IVF With Donor Eggs
    • Tandem IVF Cycle
    • IVF With Sperm Donation in Cyprus
    • IVF With Embryo Donation in Cyprus
    • Gender – Sex Selection
    • Gestational Surrogacy
    • Same Sex Gay Surrogacy
    • Surgical Sperm Retrieval
    • Pre Implantation Genetic Diagnosis PGD
    • Egg Freezing
    • Gender Selection Using Donor Eggs
    • Sickle Cell Disease Prevention
  • New Advances
    • New Advances
    • Prp Treatment
    • Stem Cell Therapy For Azoospermia
    • Advanced Sperm Selection
    • Embryoscope
    • Intralipid Therapy
  • F.A.Q.
    • FAQ
    • IVF-ICSI Questions
    • IVF With Donor Eggs
    • IVF With Donor Sperm
    • Gender Sex Selection
    • Surrogacy
    • Microsort Gender Selection
  • Travel
    • Travel
    • IVF Medication
    • Local Consultants For IVF Treatment Abroad
    • First Consultation
    • Accommodation Options
  • About
    • About North Cyprus IVF Centre
    • Our Team
      • North Cyprus IVF Team
      • Assoc. Prof. Dr. Savas Ozyigit
      • Asst. Prof. Dr. Ahmet Ozyigit
      • Asst. Prof. Dr. Idil Aslan
    • IVF Success Rates
  • Blog

© 2020 LowCostIVF - All rights reserved. Privacy Policy

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In
en_GBEnglish
en_GBEnglish tr_TRTurkish ru_RURussian it_ITItalian de_DEGerman es_ESSpanish arArabic fr_FRFrench
This website uses cookies. By continuing to use this website you are giving consent to cookies being used. Visit our Privacy and Cookie Policy.