{"id":728,"date":"2019-10-27T11:29:32","date_gmt":"2019-10-27T11:29:32","guid":{"rendered":"https:\/\/www.lowcostivf.net\/stem-cell-therapy-for-azoospermia\/"},"modified":"2025-01-04T20:05:52","modified_gmt":"2025-01-04T20:05:52","slug":"stem-cell-therapy-for-azoospermia","status":"publish","type":"page","link":"https:\/\/www.lowcostivf.net\/tr\/stem-cell-therapy-for-azoospermia\/","title":{"rendered":"Azospermi \u0130\u00e7in K\u00f6k H\u00fccre Tedavisi"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"728\" class=\"elementor elementor-728\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bdbd1b1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bdbd1b1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7f2a2bc\" data-id=\"7f2a2bc\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d2b5aba elementor-widget elementor-widget-jnews_element_header_elementor\" data-id=\"d2b5aba\" data-element_type=\"widget\" data-widget_type=\"jnews_element_header_elementor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg_block_heading jeg_block_heading_5 jeg_aligncenter jnews_module__0_69f50b0bedc31\">\n                <h3 class=\"jeg_block_title\"><span>Azospermi Tedavisi<\/span><\/h3>\n                <style>.jnews_module__0_69f50b0bedc31.jeg_block_heading_5 .jeg_block_title span, .jnews_module__0_69f50b0bedc31.jeg_block_heading_5 .jeg_block_title i { color: #7a7a7a; }<\/style>\n            <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9cbb626 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9cbb626\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a68106f\" data-id=\"a68106f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-24e31ad elementor-widget elementor-widget-jnews_post_feature_elementor\" data-id=\"24e31ad\" data-element_type=\"widget\" data-widget_type=\"jnews_post_feature_elementor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"jeg_featured featured_image\"><a href=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Stem-Cell-Therapy-For-Azoospermia.jpg\"><div class=\"thumbnail-container animate-lazy\" style=\"padding-bottom:50%\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"375\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAP\/\/\/wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==\" class=\"attachment-jnews-750x375 size-jnews-750x375 lazyload wp-post-image\" alt=\"Azospermi \u0130\u00e7in K\u00f6k H\u00fccre Tedavisi\" sizes=\"(max-width: 750px) 100vw, 750px\" data-src=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Stem-Cell-Therapy-For-Azoospermia-750x375.jpg\" data-srcset=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Stem-Cell-Therapy-For-Azoospermia-750x375.jpg 750w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Stem-Cell-Therapy-For-Azoospermia-300x150.jpg 300w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Stem-Cell-Therapy-For-Azoospermia-768x384.jpg 768w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Stem-Cell-Therapy-For-Azoospermia-1024x512.jpg 1024w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Stem-Cell-Therapy-For-Azoospermia-360x180.jpg 360w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Stem-Cell-Therapy-For-Azoospermia.jpg 1140w\" data-sizes=\"auto\" data-expand=\"700\" \/><\/div><\/a><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-002e5af\" data-id=\"002e5af\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c0f256 related_topics elementor-widget elementor-widget-text-editor\" data-id=\"6c0f256\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"color: white !important;\">\u0130lgili konular<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e95bfca elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"e95bfca\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/male-infertility\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Erkek K\u0131s\u0131rl\u0131\u011f\u0131n\u0131n Nedenleri ve Tedavisi<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24be1e3 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"24be1e3\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/surgical-sperm-retrieval\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Cerrahi Sperm Elde Etme Y\u00f6ntemleri<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12c8886 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"12c8886\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/advanced-sperm-selection\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Mikro \u00c7ip ile Sperm Se\u00e7imi<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f461849 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"f461849\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/ivf-with-sperm-donation\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Don\u00f6r Sperm ile T\u00fcp Bebek<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06d2934 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"06d2934\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/testing\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">K\u0131s\u0131rl\u0131k Testi ve Te\u015fhisi<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bfa098c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bfa098c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3d1d0056\" data-id=\"3d1d0056\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4f56e460 elementor-widget elementor-widget-text-editor\" data-id=\"4f56e460\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>K\u00f6k H\u00fccre Tedavisi Erkek K\u0131s\u0131rl\u0131\u011f\u0131na Nas\u0131l Yard\u0131mc\u0131 Olabilir?<\/h3><p>Azoospermi, bir erke\u011fin ejak\u00fclat\u0131nda canl\u0131 veya olgun sperm h\u00fccresinin olmad\u0131\u011f\u0131 bir durumdur. \u00c7o\u011fu durumda, ejak\u00fclat di\u011fer h\u00fccrelerle birlikte semen i\u00e7erebilir, bu nedenle s\u0131v\u0131 ejak\u00fclat varl\u0131\u011f\u0131 sperm h\u00fccrelerinin varl\u0131\u011f\u0131n\u0131 g\u00f6stermez. Azoospermi iki ana kategoriye ayr\u0131labilir:<\/p><p><b>obstr\u00fcktif azospermi<\/b>: Bir t\u0131kan\u0131kl\u0131k olu\u015ftu\u011funda, sperm \u00fcretimi aktif kalsa bile sperm h\u00fccreleri ejak\u00fclata sal\u0131namaz. Obstr\u00fcktif azoospermi \u00e7e\u015fitli nedenlerden kaynaklanabilir. G\u00fcn\u00fcm\u00fczde en yayg\u0131n neden, hastalar\u0131n genellikle fark\u0131nda oldu\u011fu bir durum olan vazektomidir. Ancak, ba\u015fka fakt\u00f6rler de spermin ejak\u00fclata girmesini engelleyebilir. Bu fakt\u00f6rler \u015funlard\u0131r:<\/p><p>1. <u>Kanal Sistemi Anormallikleri<\/u><br \/>Sperm h\u00fccreleri \u00fcretraya ula\u015fmak i\u00e7in kanal sisteminden ge\u00e7melidir. Testislerde (testisler) \u00fcretildikten sonra sperm, epididim, vas deferens (veya ductus deferens), ejak\u00fclat\u00f6r kanal ve \u00fcretra dahil olmak \u00fczere \u00e7e\u015fitli yap\u0131lardan ge\u00e7er. Spermin bu yap\u0131lar aras\u0131nda veya bu yap\u0131lar arac\u0131l\u0131\u011f\u0131yla ta\u015f\u0131nmas\u0131nda herhangi bir kesinti, yolunu t\u0131kayabilir. (Bu yap\u0131lar\u0131n g\u00f6rsel bir temsili i\u00e7in a\u015fa\u011f\u0131daki \u015fekle bak\u0131n.)<\/p><p>2. <u>Bo\u015falma Disfonksiyonu<\/u><br \/>Bo\u015falmadan \u00f6nce spermin \u00fcretraya b\u0131rak\u0131ld\u0131\u011f\u0131 emisyon s\u00fcreci ar\u0131zalanabilir. Bu i\u015flev bozuklu\u011fu n\u00f6rolojik hasardan veya baz\u0131 durumlarda kontrols\u00fcz diyabetten kaynaklanabilir.<\/p><p>Obstr\u00fcktif azospermi vakalar\u0131nda,\u00a0<a href=\"\/tr\/surgical-sperm-retrieval\/\">cerrahi sperm \u00e7\u0131karma teknikleri<\/a>\u00a0Genellikle IVF d\u00f6ng\u00fcs\u00fc s\u0131ras\u0131nda kullan\u0131lacak kabul edilebilir say\u0131da canl\u0131 sperm h\u00fccresinin elde edilmesine yard\u0131mc\u0131 olur.<\/p><p><img decoding=\"async\" class=\"aligncenter\" style=\"width: auto; max-width: 100%;\" src=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/10\/shutterstock-327830681.jpg\" alt=\"obstr\u00fcktif ve obstr\u00fcktif olmayan azospermi\" \/><\/p><p><b>Obstr\u00fcktif olmayan azospermi tedavisi<\/b>: Non-obstr\u00fcktif azoospermi (NOA), testislerde sperm \u00fcretiminin bozulmas\u0131 nedeniyle ejak\u00fclatta sperm bulunmamas\u0131yla karakterize bir durumdur. \u00dcreme sistemindeki t\u0131kan\u0131kl\u0131klardan kaynaklanan obstr\u00fcktif azoosperminin aksine, NOA i\u00e7sel testis disfonksiyonundan kaynaklan\u0131r. Bu durum genetik anormallikler (Klinefelter sendromu veya Y kromozomu mikrodelesyonlar\u0131 gibi), hormonal dengesizlikler veya enfeksiyonlar, travma, kemoterapi veya radyasyondan kaynaklanan testis hasarlar\u0131 nedeniyle ortaya \u00e7\u0131kabilir. \u00c7o\u011fu durumda, altta yatan neden idiyopatik kal\u0131r. NOA erkek k\u0131s\u0131rl\u0131\u011f\u0131n\u0131n \u00f6nemli bir nedenidir ve v\u00fccut azalan spermatogenezi telafi etmeye \u00e7al\u0131\u015f\u0131rken genellikle daha k\u00fc\u00e7\u00fck testis hacmi ve y\u00fcksek folik\u00fcl uyar\u0131c\u0131 hormon (FSH) seviyeleri ile kendini g\u00f6sterir. Tan\u0131 genellikle hormonal profilleme, genetik test ve bazen olgun spermin yoklu\u011funu do\u011frulamak i\u00e7in testis biyopsisi i\u00e7erir.<\/p><p>Testis biyopsisinin amac\u0131, testis dokusunu daha az olgun sperm h\u00fccresi varl\u0131\u011f\u0131 a\u00e7\u0131s\u0131ndan iyice incelemektir. Spermatogenez (sperm \u00fcretimi ve olgunla\u015fma s\u00fcreci) tam olarak tamamlanmasa bile, muhtemelen kullan\u0131labilecek daha erken evrelerde sperm h\u00fccreleri mevcut olabilir. A\u015fa\u011f\u0131daki diyagram, k\u00f6k h\u00fccrelerden olgun sperm h\u00fccrelerine kadar spermatogenezin tam d\u00f6ng\u00fcs\u00fcn\u00fc g\u00f6stermektedir:<\/p><p>\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0ba840 elementor-widget elementor-widget-image\" data-id=\"a0ba840\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"508\" height=\"768\" src=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2025\/01\/stem_cell.png\" class=\"attachment-full size-full wp-image-16812\" alt=\"\" srcset=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2025\/01\/stem_cell.png 508w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2025\/01\/stem_cell-198x300.png 198w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2025\/01\/stem_cell-8x12.png 8w\" sizes=\"(max-width: 508px) 100vw, 508px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-86fd01b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"86fd01b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-72446d7\" data-id=\"72446d7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0344233 elementor-widget elementor-widget-text-editor\" data-id=\"0344233\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Hastan\u0131n biyopsisinde ge\u00e7 evre spermatidlerin (uzun spermatidler) varl\u0131\u011f\u0131 ortaya \u00e7\u0131karsa, do\u011fal gebe kalma i\u015fe yaramayacak olsa bile, ge\u00e7 evre spermatidler genellikle ICSI kullan\u0131m\u0131yla bir IVF d\u00f6ng\u00fcs\u00fc s\u0131ras\u0131nda ba\u015far\u0131yla kullan\u0131l\u0131r. Ancak, uzun spermatidlerden \u00f6nceki herhangi bir sperm olgunla\u015fma a\u015famas\u0131 ba\u015far\u0131l\u0131 bir IVF sonucuyla sonu\u00e7lanmayacakt\u0131r.<\/p>\n<p>Bu noktada, e\u011fer germ h\u00fccreleri yoksa ve sadece sertoli h\u00fccre sendromu tan\u0131s\u0131 konulmu\u015fsa, o zaman \u00e7ocuk sahibi olmak i\u00e7in tek se\u00e7enek don\u00f6r spermi kullan\u0131m\u0131 veya evlat edinme olacakt\u0131r. Germ h\u00fccreleri, olgun sperm h\u00fccrelerine d\u00f6n\u00fc\u015fme ve farkl\u0131la\u015fma potansiyeline sahip olgunla\u015fmam\u0131\u015f sperm h\u00fccreleridir. Bunlar olgunla\u015fmam\u0131\u015f ve farkl\u0131la\u015fmam\u0131\u015f sperm h\u00fccreleri olarak d\u00fc\u015f\u00fcn\u00fclebilir. Bunlar \u015funlar\u0131 i\u00e7erir:<\/p>\n<p>\u2013 Spermatogonia<br>\u2013 Birincil spermatositler<br>\u2013 \u0130kincil spermatositler<br>\u2013 Erken evre spermatidler<br>\u2013 Ge\u00e7 evre spermatidler<\/p>\n<p>Testis dokusunda germ h\u00fccrelerinin varl\u0131\u011f\u0131 k\u00f6k h\u00fccre tedavisi i\u00e7in \u00f6n ko\u015fuldur. Bunun nedeni basittir. K\u00f6k h\u00fccre tedavisinde hastan\u0131n kendi ya\u011f dokusundan al\u0131nan mezenkimal k\u00f6k h\u00fccreleri kullan\u0131r\u0131z. Mezenkimal k\u00f6k h\u00fccrelerin s\u0131n\u0131rl\u0131 farkl\u0131la\u015fma potansiyeli vard\u0131r. Ancak do\u011fru ko\u015fullar sa\u011fland\u0131\u011f\u0131nda bir\u00e7ok h\u00fccre tipine farkl\u0131la\u015fabilirler. Mezenkimal k\u00f6k h\u00fccreler, belirli bir h\u00fccre tipine farkl\u0131la\u015fmak \u00fczere \u00f6zel olarak programlanmad\u0131klar\u0131 s\u00fcrece \u00e7o\u011funlukla \u00e7evredeki h\u00fccre tiplerine farkl\u0131la\u015fma e\u011filimindedir. Tedavilerimizde h\u00fccre programlamas\u0131 s\u00f6z konusu de\u011fildir. Hastan\u0131n kendi ya\u011f dokusundan elde edilen k\u00f6k h\u00fccreler izole edilir ve germ h\u00fccrelerinin bulundu\u011fu testis dokusuna enjekte edilir. \u00c7evrede germ h\u00fccreleri bulundu\u011fundan k\u00f6k h\u00fccreler \u015fablon olarak bunlar\u0131 takip eder ve onlar da germ h\u00fccrelerine farkl\u0131la\u015f\u0131r. Ancak bu s\u00fcrecin yaln\u0131zca bir par\u00e7as\u0131d\u0131r. Hastan\u0131n testislerindeki mevcut germ h\u00fccrelerinin spermatogenezi tamamlay\u0131p tam olgun sperm h\u00fccresi olamayaca\u011f\u0131 g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, b\u00f6yle bir farkl\u0131la\u015fmay\u0131 te\u015fvik etmek i\u00e7in ek ad\u0131mlar olmas\u0131 gerekir.<\/p>\n<p>Seminifer t\u00fcb\u00fcllere k\u00f6k h\u00fccreleri enjekte etti\u011fimizde, hastan\u0131n periferik kan \u00f6rne\u011finden t\u00fcretilen kendi trombositten zengin plazmas\u0131n\u0131 da enjekte ediyoruz. Trombositten zengin plazma, h\u00fccresel b\u00fcy\u00fcme ve geli\u015fmeye izin veren ve dokuya kan ak\u0131\u015f\u0131n\u0131 iyile\u015ftiren b\u00fcy\u00fcme fakt\u00f6rleri a\u00e7\u0131s\u0131ndan zengindir. Bu nedenle, k\u00f6k h\u00fccreler geli\u015fimlerini kolayla\u015ft\u0131rmak i\u00e7in yak\u0131n \u00e7evrelerine zengin bir b\u00fcy\u00fcme fakt\u00f6r\u00fc inf\u00fczyonundan yararlan\u0131rlar. Ayr\u0131ca, testislerdeki h\u00fccresel ileti\u015fimi art\u0131rmak i\u00e7in plasentadan t\u00fcretilen ekzosomlar kullan\u0131r\u0131z.<\/p>\n<p>K\u00f6k h\u00fccre tedavisinin b\u00fct\u00fcn\u00fc \u015fu ama\u00e7lara y\u00f6neliktir:<\/p>\n<p>1- Testis dokusuna k\u00f6k h\u00fccre verilerek testis dokusundaki germ h\u00fccresi pop\u00fclasyonunun art\u0131r\u0131lmas\u0131.<\/p>\n<p>2- B\u00fcy\u00fcme fakt\u00f6rlerinin yard\u0131m\u0131yla bu germ h\u00fccrelerinin b\u00fcy\u00fcmesini ve geli\u015fmesini sa\u011flay\u0131n.<\/p>\n<p>3- Ekzosomlar yard\u0131m\u0131yla h\u00fccresel ileti\u015fimi iyile\u015ftirmek ve hormonal uyar\u0131lara cevab\u0131 kolayla\u015ft\u0131rmak.<\/p>\n<p><strong>Trombositten Zengin Plazma (PRP) Nedir?<\/strong>? PRP, bir bireyin kendi kan\u0131ndan elde edilen, iyile\u015fmeyi ve doku yenilenmesini destekleyen b\u00fcy\u00fcme fakt\u00f6rleri ve biyoaktif proteinlerle zenginle\u015ftirilmi\u015f bir trombosit konsantrasyonudur. PRP, hasarl\u0131 dokular\u0131n onar\u0131m\u0131n\u0131 h\u0131zland\u0131rmak, iltihab\u0131 azaltmak ve h\u00fccre \u00e7o\u011falmas\u0131n\u0131 uyarmak i\u00e7in t\u0131bbi ve estetik tedavilerde yayg\u0131n olarak kullan\u0131l\u0131r.<\/p>\n<p>Trombositler, a\u015fa\u011f\u0131daki gibi b\u00fcy\u00fcme fakt\u00f6rlerini serbest b\u0131rakarak yara iyile\u015fmesi ve doku onar\u0131m\u0131nda \u00f6nemli bir rol oynar:<br><br>\u2981&nbsp;&nbsp;&nbsp; <strong>Trombosit Kaynakl\u0131 B\u00fcy\u00fcme Fakt\u00f6r\u00fc (PDGF)<\/strong>: H\u00fccre b\u00fcy\u00fcmesini ve yeni kan damar\u0131 olu\u015fumunu uyar\u0131r.<br>\u2981&nbsp;&nbsp;&nbsp; <strong>D\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc B\u00fcy\u00fcme Fakt\u00f6r\u00fc-Beta (TGF-\u03b2)<\/strong>:Doku onar\u0131m\u0131n\u0131 destekler ve iltihab\u0131 azalt\u0131r.<br>\u2981&nbsp;&nbsp;&nbsp; <b>Vask\u00fcler Endotelyal B\u00fcy\u00fcme Fakt\u00f6r\u00fc (VEGF)<\/b>: Yeni kan damarlar\u0131n\u0131n olu\u015fumunu te\u015fvik eder.<br>\u2981&nbsp;&nbsp;&nbsp; <strong>Epidermal B\u00fcy\u00fcme Fakt\u00f6r\u00fc (EGF)<\/strong>: H\u00fccre yenilenmesini ve yara iyile\u015fmesini destekler.<\/p>\n<p>PRP hedef b\u00f6lgeye enjekte edildi\u011finde, bu b\u00fcy\u00fcme fakt\u00f6rleri k\u00f6k h\u00fccre aktivasyonu ve kolajen sentezi de dahil olmak \u00fczere v\u00fccudun do\u011fal iyile\u015fme s\u00fcre\u00e7lerini harekete ge\u00e7irir ve aktive eder.<\/p>\n<p><strong>Eksozom nedir?<\/strong><br>Eksozomlar, interstisyel bo\u015fluklarda ve v\u00fccut s\u0131v\u0131lar\u0131nda bulunan k\u00fc\u00e7\u00fck nanovezik\u00fcllerdir. Boyutlar\u0131 nedeniyle, eksozomlar her zaman fizyolojik i\u015flevi olmayan eserler veya h\u00fccresel \u00e7\u00f6pler olarak g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Bununla birlikte, t\u0131p alan\u0131ndaki ara\u015ft\u0131rmalardaki ilerlemelerle, art\u0131k titiz bir h\u00fccre i\u00e7i ileti\u015fim sisteminin par\u00e7as\u0131 olduklar\u0131 bilinmektedir.<\/p>\n<p>Eksozomlar, her t\u00fcr h\u00fccresel ileti\u015fimde yer almalar\u0131yla bilinir. Benzer h\u00fccre t\u00fcrleri aras\u0131nda yerel otokrin sinyaller, farkl\u0131 h\u00fccre t\u00fcrleri aras\u0131nda yerel parakrin sinyaller ve uzak endokrin sinyaller sa\u011flarlar. Bu kadar kapsaml\u0131 h\u00fccresel sinyalle\u015fmeye kat\u0131l\u0131m, onlara &quot;sinyalozomlar&quot; ad\u0131n\u0131 kazand\u0131rd\u0131. Eksozomlar v\u00fccuda girdi\u011finde, h\u00fccrelerin genel sa\u011fl\u0131\u011f\u0131na ve i\u015flevine yard\u0131mc\u0131 olan t\u00fcm kanallar arac\u0131l\u0131\u011f\u0131yla ileti\u015fimi geli\u015ftirirler.<\/p>\n<p>Yeti\u015fkin k\u00f6k h\u00fccrelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda eksozomlar, h\u00fccresel b\u00fcy\u00fcme, geli\u015fme ve yenilenme i\u00e7in gerekli olan 300% daha fazla b\u00fcy\u00fcme fakt\u00f6r\u00fc i\u00e7erir. Eksozomlar, IV inf\u00fczyon yoluyla verilebilir veya do\u011frudan enjeksiyonla belirli bir b\u00f6lgeye y\u00f6nlendirilebilir.<\/p>\n<p><strong>K\u00f6k H\u00fccre Tedavisi Nas\u0131l Yap\u0131l\u0131r?<\/strong><br>Kuzey K\u0131br\u0131s T\u00fcp Bebek Merkezi&#039;nde, obstr\u00fcktif olmayan azospermi tedavisi i\u00e7in uygulad\u0131\u011f\u0131m\u0131z k\u00f6k h\u00fccre tedavileri, mezenkimal k\u00f6k h\u00fccreler, trombositten zengin plazma ve ekzosomlar\u0131n bir kokteylini kullan\u0131r. K\u00f6k h\u00fccre izolasyonu, liposuction ad\u0131 verilen cerrahi bir prosed\u00fcr gerektirir.<\/p>\n<p>bu <strong>liposuction prosed\u00fcr\u00fc<\/strong> elde etmek i\u00e7in <strong>mezenkimal k\u00f6k h\u00fccreler (MSC&#039;ler)<\/strong> MSC&#039;lerin zengin bir kayna\u011f\u0131 olan ya\u011f dokusunu toplamak i\u00e7in kullan\u0131lan minimal invaziv bir cerrahi tekniktir. Cerrahi prosed\u00fcr bir dizi ad\u0131m\u0131 i\u00e7erir:<\/p>\n<p><strong>1. Ameliyat \u00d6ncesi Haz\u0131rl\u0131k:<\/strong><br>Hasta, prosed\u00fcre uygun oldu\u011fundan emin olmak i\u00e7in t\u0131bbi bir de\u011ferlendirmeden ge\u00e7er. Bu, bir dizi hormon testi, potansiyel olarak skrotum de\u011ferlendirmesi ve seminifer t\u00fcb\u00fcllerin h\u00fccreselli\u011fini de\u011ferlendirmek i\u00e7in bir testis biyopsisi i\u00e7erir.<\/p>\n<p>Hastadan ayr\u0131ca karaci\u011fer ve b\u00f6brek fonksiyonlar\u0131n\u0131 kontrol etmek i\u00e7in bir dizi kan testi yapt\u0131rmas\u0131 ve ayr\u0131ca Alfa-fetoprotein (AFP) ve beta insan koryonik gonadotropin (b-hCG) gibi baz\u0131 t\u00fcm\u00f6r belirleyicilerini kontrol etmesi istenir.<\/p>\n<p>2. <strong>Tumescent \u00c7\u00f6zelti Enjeksiyonu<\/strong>:<br>Tuzlu su, lidokain (lokal anestezik) ve epinefrin (kanamay\u0131 azaltmak i\u00e7in) i\u00e7eren bir tumescent sol\u00fcsyonu hedeflenen b\u00f6lgeye enjekte edilir. Bu sol\u00fcsyon ya\u011f h\u00fccrelerinin gev\u015femesine yard\u0131mc\u0131 olur, a\u011fr\u0131y\u0131 azalt\u0131r ve i\u015flem s\u0131ras\u0131nda kanamay\u0131 en aza indirir.<\/p>\n<p>3. <strong>Ya\u011f Alma (Liposuction)<\/strong>:<br>Ciltte k\u00fc\u00e7\u00fck bir kesi yap\u0131l\u0131r ve <strong>kan\u00fcl<\/strong> (ince, i\u00e7i bo\u015f bir t\u00fcp) yerle\u015ftirilir. Kan\u00fcl, kar\u0131n, uyluk veya kal\u00e7a gibi b\u00f6lgelerden ya\u011f dokusunu nazik\u00e7e emen bir vakum cihaz\u0131na ba\u011flan\u0131r.<\/p>\n<p>4. <strong>Ya\u011f Dokusunun \u0130\u015flenmesi<\/strong>:<br>\u00c7\u0131kar\u0131lan ya\u011f steril kaplara toplan\u0131r ve MSC&#039;leri izole etmek i\u00e7in i\u015flenir. \u0130\u015fleme \u015funlar\u0131 i\u00e7erir:<br><strong>Santrif\u00fcjleme<\/strong> ya\u011f\u0131 kan ve s\u0131v\u0131lar gibi di\u011fer bile\u015fenlerden ay\u0131rmak i\u00e7in, <br><strong>Enzimatik sindirim<\/strong> Kolajenaz kullanarak h\u00fccre d\u0131\u015f\u0131 matrisi par\u00e7alamak ve MSC&#039;leri serbest b\u0131rakmak.<br><strong>Filtreleme ve Y\u0131kama<\/strong> MSC&#039;leri ar\u0131nd\u0131rmak ve kal\u0131nt\u0131lar\u0131 temizlemek i\u00e7in.<\/p>\n<p>5. <strong>Yeniden yerle\u015ftirme<\/strong>:<br>MSC&#039;ler PRP ve ekzosomlarla bir kokteyl haline getirilir ve do\u011frudan testislerdeki hedef b\u00f6lgelere enjekte edilir. T\u00fcm prosed\u00fcr, hasta sedasyon alt\u0131ndayken birka\u00e7 saat i\u00e7inde yap\u0131l\u0131r. Bu nedenle, liposuction ve reimplantasyon prosed\u00fcrleri iki ayr\u0131 sedasyon gerektirmeden tek seferde ger\u00e7ekle\u015ftirilir.<\/p>\n<p>\u0130\u015flem genel olarak g\u00fcvenli olsa da, liposuction veya reimplantasyon b\u00f6lgesinde k\u00fc\u00e7\u00fck morarma, enfeksiyon veya rahats\u0131zl\u0131k gibi riskler vard\u0131r. Bu teknik, ya\u011fdan t\u00fcretilen MSC&#039;lerin y\u00fcksek potansiyeli ve \u00e7ok y\u00f6nl\u00fcl\u00fc\u011f\u00fc nedeniyle rejeneratif t\u0131pta yayg\u0131n olarak kullan\u0131l\u0131r.<\/p>\n<p><strong>K\u0131br\u0131s&#039;ta Gerekli Kal\u0131\u015f S\u00fcresi<\/strong>:<br>Hastalar\u0131m\u0131z\u0131n \u00e7o\u011fu yurtd\u0131\u015f\u0131ndan bize geliyor. \u0130\u015f veya evdeki taahh\u00fctler nedeniyle seyahat s\u00fcreleri s\u0131n\u0131rl\u0131 olabilir. Bu nedenle, K\u0131br\u0131s&#039;ta kal\u0131\u015f s\u00fcresinin en aza indirilebilmesi i\u00e7in hastan\u0131n var\u0131\u015f\u0131ndan \u00f6nce \u00f6n testlerin\/biyopsilerin yerel olarak yap\u0131lmas\u0131n\u0131 istiyoruz. K\u00f6k h\u00fccre tedavisi i\u00e7in K\u0131br\u0131s&#039;ta yakla\u015f\u0131k 3 g\u00fcn kalman\u0131z bekleniyor. Bu, gerekli ameliyat \u00f6ncesi testleri yapmak, kan \u00f6rne\u011finizi almak ve prosed\u00fcr\u00fc ger\u00e7ekle\u015ftirmek i\u00e7in bize yeterli zaman tan\u0131yacakt\u0131r. G\u00f6zlem i\u00e7in hastanemizde bir gece kalman\u0131z bekleniyor ve ertesi g\u00fcn eve d\u00f6nebileceksiniz.<\/p>\n<p><b>\u0130\u015flemden Sonra Neler Bekleyebilirsiniz? Ba\u015far\u0131 Oranlar\u0131:<\/b><br>K\u00f6k h\u00fccre enjeksiyonundan sonra, etkiyi g\u00f6zlemlemek i\u00e7in \u00fc\u00e7 ayl\u0131k bir bekleme s\u00fcresi vard\u0131r. Spermatogenez (sperm h\u00fccrelerinin \u00fcretimi ve olgunla\u015fmas\u0131) yakla\u015f\u0131k 65 ila 70 g\u00fcn s\u00fcrer. Bu nedenle, implante edilen k\u00f6k h\u00fccrelerin herhangi bir etkiyi g\u00f6zlemleyebilmemiz i\u00e7in bu kadar zamana ihtiyac\u0131 olacakt\u0131r.<\/p>\n<p>\u0130\u015flemin ba\u015far\u0131s\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde ba\u015flang\u0131\u00e7ta testis dokusunun bazal h\u00fccreselli\u011fine ba\u011fl\u0131d\u0131r. Testis dokusunda erken veya ge\u00e7 evre spermatidleri olan hastalar (J<strong>ohnsen puan\u0131 7 veya 8<\/strong>) k\u00f6k h\u00fccre tedavisiyle ba\u015far\u0131 \u015fans\u0131 en y\u00fcksek olan hasta grubudur. \u00c7o\u011fu durumda, \u00fc\u00e7 ayl\u0131k s\u00fcreden sonra ejak\u00fclatta olgun sperm h\u00fccrelerini g\u00f6zlemleyebiliyoruz. Ejak\u00fclattaki olgun sperm h\u00fccrelerinin say\u0131s\u0131 do\u011fal gebe kalma i\u00e7in yeterli olmasa da, bu hasta grubuyla s\u0131kl\u0131kla ba\u015far\u0131l\u0131 bir IVF d\u00f6ng\u00fcs\u00fc planl\u0131yor ve uyguluyoruz. Bu hasta grubunda ejak\u00fclatta olgun sperm h\u00fccrelerini ba\u015far\u0131yla elde etme \u015fans\u0131 yakla\u015f\u0131k 75%&#039;dir.<\/p>\n<p>Seminifer t\u00fcb\u00fcllerde spermatid bulunmayan (belki birka\u00e7 tane) ancak sekonder spermatositleri bulunan hastalar (<strong>Johnsen puan\u0131 5 ila 6<\/strong>) ayr\u0131ca olgun sperm h\u00fccrelerinin ejak\u00fclata girebilmesiyle sonu\u00e7lanabilen spermatogenik aktivitelerinde bir iyile\u015fme g\u00f6rme e\u011filimindedirler. Ancak bu hasta grubunda, ejak\u00fclatta olgun sperm h\u00fccrelerinin g\u00f6zlemlenmesi daha az yayg\u0131nd\u0131r. Bu hasta grubunda beklentimiz, IVF d\u00f6ng\u00fcs\u00fc s\u0131ras\u0131nda kullan\u0131lacak bir testis biyopsisinde olgunla\u015fan spermatidler bulabilmektir. K\u00f6k h\u00fccre tedavisinden \u00fc\u00e7 ay sonra yap\u0131lan semen analizinde ejak\u00fclatta herhangi bir sperm h\u00fccresi g\u00f6r\u00fclmezse, bir sonraki ad\u0131m ICSI s\u0131ras\u0131nda kullan\u0131labilecek canl\u0131 sperm h\u00fccreleri elde etmek i\u00e7in bir testis spermi \u00e7\u0131karma prosed\u00fcr\u00fc organize etmek olacakt\u0131r. Bu hasta grubunda ejak\u00fclatta olgun sperm h\u00fccreleri elde etme \u015fans\u0131 yakla\u015f\u0131k 25%&#039;dir. Ejak\u00fclatta veya TESE yoluyla canl\u0131 sperm h\u00fccreleri bulma \u015fans\u0131 yakla\u015f\u0131k 40%&#039;dir.<\/p>\n<p>Seminifer t\u00fcb\u00fcllerinde yaln\u0131zca birincil spermatosit bulunan hastalar (<strong>Johnsen puan\u0131 4<\/strong>) k\u00f6k h\u00fccre prosed\u00fcr\u00fcnden sonra ejak\u00fclatta olgun sperm h\u00fccreleri g\u00f6zlemlemeleri olas\u0131 de\u011fildir. Vakalar\u0131n \u00e7o\u011funda, doku germ h\u00fccreleriyle daha fazla n\u00fcfusland\u0131\u011f\u0131 anlam\u0131nda spermatojenik aktivitede bir iyile\u015fme g\u00f6r\u00fcyoruz. Ancak hastalar\u0131n b\u00fcy\u00fck \u00e7o\u011funlu\u011funda, ICSI s\u0131ras\u0131nda kullan\u0131lacak kadar olgun sperm h\u00fccresi bulam\u0131yoruz. Bu hasta grubunda ba\u015far\u0131 15% olarak tahmin edilebilir, yani hastalar\u0131n 15%&#039;si IVF d\u00f6ng\u00fcs\u00fcnde kullan\u0131labilecek kadar olgun sperm h\u00fccresine sahip olacakt\u0131r.<\/p>\n<p>Bug\u00fcne kadarki hasta istatistiklerimize g\u00f6re, seminifer t\u00fcb\u00fcllerde sadece spermatogonium bulunan hastalarda (<strong>Johnsen&#039;in puan\u0131 3<\/strong>) k\u00f6k h\u00fccre prosed\u00fcr\u00fcnden sonra ICSI s\u0131ras\u0131nda kullan\u0131labilecek kadar olgun sperm h\u00fccresine sahip olma \u015fans\u0131na sahip olma olas\u0131l\u0131\u011f\u0131 y\u00fcksektir.<\/p>\n<p>Johnsen skoru 2 ve alt\u0131nda olan hasta grubunda (sadece Sertoli h\u00fccre sendromu veya hi\u00e7 h\u00fccre olmayan) ba\u015far\u0131l\u0131 bir sonu\u00e7 beklemiyoruz.<\/p>\n<h4>Johnsen Puan\u0131 Nedir?<\/h4>\n<p>bu <strong>Johnsen Puanlama Sistemi<\/strong> seminifer t\u00fcb\u00fcllerde spermatogenezi (sperm \u00fcretimi) de\u011ferlendirerek testis biyopsi \u00f6rneklerini de\u011ferlendirmek i\u00e7in kullan\u0131lan bir histolojik y\u00f6ntemdir. SG Johnsen taraf\u0131ndan 1970 y\u0131l\u0131nda geli\u015ftirilen sistem, germ h\u00fccrelerinin varl\u0131\u011f\u0131 ve olgunlu\u011fu ile spermatogenezin genel durumuna g\u00f6re her bir seminifer t\u00fcb\u00fcle say\u0131sal bir puan atar. Genellikle erkek k\u0131s\u0131rl\u0131\u011f\u0131n\u0131n de\u011ferlendirilmesinde kullan\u0131l\u0131r.<\/p>\n<p><b>Puanlama Kriterleri<\/b><br>Her bir seminifer t\u00fcb\u00fcle, a\u015fa\u011f\u0131dakiler aras\u0131nda de\u011fi\u015fen bir puan atan\u0131r: <b>1 ila 10<\/b> A\u015fa\u011f\u0131daki kriterlere g\u00f6re:<br><strong>Puan 10<\/strong>: \u00c7ok say\u0131da spermatozoan\u0131n g\u00f6r\u00fclebildi\u011fi tam spermatogenez.<br><strong>Puan 9<\/strong>: Hafif derecede azalm\u0131\u015f spermatogenez ancak \u00e7ok say\u0131da ge\u00e7 evre spermatid mevcut.<br><strong>Puan 8<\/strong>: Az say\u0131da ge\u00e7 spermatid, orta derecede bozulmu\u015f spermatogenezi g\u00f6sterir.<br><strong>Puan 7<\/strong>: Erken d\u00f6nemde \u00e7ok say\u0131da spermatit mevcut ancak ge\u00e7 d\u00f6nemde spermatit veya spermatozoa yok.<br><strong>Puan 6<\/strong>: Erken spermatitlerin az say\u0131da olmas\u0131 ancak ge\u00e7 spermatit veya spermatozoa bulunmamas\u0131.<br><strong>Puan 5<\/strong>: \u00c7ok say\u0131da spermatosit mevcut, ancak spermatid veya spermatozoa yok.<br><strong>Puan 4<\/strong>: Birka\u00e7 spermatosit mevcut, ancak spermatid veya spermatozoa yok.<br><strong>Puan 3<\/strong>: Spermatogonyum (germ h\u00fccresi \u00f6nc\u00fclleri) mevcuttur ancak spermatosit, spermatid veya spermatozoa yoktur.<br><b>Puan 2<\/b>: Sadece Sertoli h\u00fccreleri var, germ h\u00fccresi yok.<br><b>Puan 1<\/b>:Biyopside seminifer t\u00fcb\u00fcller mevcut de\u011fil (a\u015f\u0131r\u0131 testis hasar\u0131).<\/p>\n<p><strong>Puanlar\u0131n Yorumlanmas\u0131<br><\/strong><br>A <b>daha y\u00fcksek puan<\/b> normal veya normale yak\u0131n spermatogenezi g\u00f6sterir.<br>A <b>d\u00fc\u015f\u00fck puan<\/b> Spermatogenez bozuklu\u011funu veya spermatogenezin olmad\u0131\u011f\u0131n\u0131 yans\u0131t\u0131r.<br>Hesaplayarak <b>Johnsen puan\u0131 ortalamas\u0131<\/b> \u0130ncelenen t\u00fcm t\u00fcb\u00fcllerde spermatogenik bozulman\u0131n derecesini belirleyebilir ve yard\u0131mc\u0131 \u00fcreme teknolojilerine ge\u00e7mek, k\u00f6k h\u00fccre tedavilerini kullanmak veya don\u00f6r se\u00e7eneklerini de\u011ferlendirmek gibi tedavi se\u00e7enekleri hakk\u0131nda bilin\u00e7li kararlar alabiliriz.<\/p>\n<p><b>Obstr\u00fcktif Olmayan Azospermi \u0130\u00e7in K\u00f6k H\u00fccre Tedavisinin Maliyeti:<br><\/b>Non-obstr\u00fcktif azoospermi tedavisinde k\u00f6k h\u00fccre tedavisinin maliyeti PRP protokol\u00fc, liposuction ve k\u00f6k h\u00fccre safla\u015ft\u0131rma, ekzosomlar ve testis dokusuna implantasyon dahil 7.000 Euro&#039;dur. Bu teklife hastanede bir gece kalma da dahildir.<\/p>\n<p>L\u00fctfen \u00e7ekinmeyin <a href=\"\/tr\/contact\/\">bize Ula\u015f\u0131n<\/a> daha fazla bilgi i\u00e7in.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f58b9c1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f58b9c1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8a9c72c\" data-id=\"8a9c72c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-85f2919 elementor-widget elementor-widget-jnews_element_header_elementor\" data-id=\"85f2919\" data-element_type=\"widget\" data-widget_type=\"jnews_element_header_elementor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg_block_heading jeg_block_heading_1 jeg_alignleft jnews_module__2_69f50b0c027e4\">\n                <h3 class=\"jeg_block_title\"><span>T\u00fcp Bebek Teknolojilerinde Yeni Geli\u015fmeler<\/span><\/h3>\n                \n            <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0e9dafc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0e9dafc\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-527da90\" data-id=\"527da90\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f5ee4ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f5ee4ce\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-2fbca52\" data-id=\"2fbca52\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-53cab9f elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"53cab9f\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/prp-treatment\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Prp-Treatment-350x250.jpg);\" role=\"img\" aria-label=\"Prp Tedavisi\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tPRP Tedavisi\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: justify; !important;\">Trombositten Zengin Plazma (PRP) Tedavileri Kad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131na Nas\u0131l Yard\u0131mc\u0131 Olabilir?<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">PRP Tedavisi<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-4405b42\" data-id=\"4405b42\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-18d29d5 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"18d29d5\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/advanced-sperm-selection\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Advanced-Sperm-Selection-350x250.jpg);\" role=\"img\" aria-label=\"Geli\u015fmi\u015f Sperm Se\u00e7imi\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tMikro Ak\u0131\u015fkan Sperm Se\u00e7imi\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: justify; !important;\">Sperm se\u00e7imi i\u00e7in yeni &quot;entegre mikroak\u0131\u015fkan \u00e7ip&quot; y\u00f6ntemi.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Sperm Se\u00e7imi<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-fa37700\" data-id=\"fa37700\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ae916a5 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"ae916a5\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/embryoscope\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2015\/07\/Embryoscope-350x250.jpg);\" role=\"img\" aria-label=\"embriyoskop\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tembriyoskop\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: justify; !important;\">IVF i\u00e7in Embriyo Taramas\u0131 ve Se\u00e7imi i\u00e7in H\u0131zland\u0131r\u0131lm\u0131\u015f G\u00f6r\u00fcnt\u00fcleme.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">embriyoskop<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-8cdecab\" data-id=\"8cdecab\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ab5b8bf elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"ab5b8bf\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/intralipid-therapy\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/intralipid_therapy-350x250.jpg);\" role=\"img\" aria-label=\"intralipid_terapisi\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t\u0130ntralipid Tedavisi\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: justify; !important;\">IVF tedavilerinden \u00f6nce ve sonra intralipid inf\u00fczyon tedavisi.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">intralipid<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Azospermi Tedavisi Boyutu: 750\u00d7375 \u0130lgili Konular Erkek K\u0131s\u0131rl\u0131\u011f\u0131n\u0131n Nedenleri ve Y\u00f6netimi Cerrahi Sperm Ekstraksiyon Y\u00f6ntemleri Mikro \u00c7ip ile Sperm Se\u00e7imi Don\u00f6r ile T\u00fcp Bebek Sperm K\u0131s\u0131rl\u0131\u011f\u0131 Testi ve Tan\u0131s\u0131 K\u00f6k H\u00fccre Tedavisi Erkek K\u0131s\u0131rl\u0131\u011f\u0131na Nas\u0131l Yard\u0131mc\u0131 Olabilir? Azospermi, yumurtal\u0131klarda canl\u0131 veya olgun sperm h\u00fccrelerinin bulunmad\u0131\u011f\u0131 bir durumdur.<\/p>","protected":false},"author":1,"featured_media":1406,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-728","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Stem Cell Therapy For Azoospermia - North Cyprus IVF<\/title>\n<meta name=\"description\" content=\"How does Stem Cell therapy for Non-Obstructive Azoospermia work? 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