{"id":705,"date":"2019-10-27T11:29:19","date_gmt":"2019-10-27T11:29:19","guid":{"rendered":"https:\/\/www.lowcostivf.net\/ivf-over-50-for-older-women\/"},"modified":"2026-01-17T20:13:16","modified_gmt":"2026-01-17T20:13:16","slug":"ivf-over-50-for-older-women","status":"publish","type":"page","link":"https:\/\/www.lowcostivf.net\/tr\/ivf-over-50-for-older-women\/","title":{"rendered":"Ya\u015fl\u0131 Kad\u0131nlar \u0130\u00e7in 50 Ya\u015f \u00dcst\u00fc T\u00fcp Bebek"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"705\" class=\"elementor elementor-705\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9dcb937 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9dcb937\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1b3c73d\" data-id=\"1b3c73d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cc0203c elementor-widget elementor-widget-jnews_element_header_elementor\" data-id=\"cc0203c\" data-element_type=\"widget\" data-widget_type=\"jnews_element_header_elementor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg_block_heading jeg_block_heading_5 jeg_aligncenter jnews_module__0_69f55ee3f3314\">\n                <h3 class=\"jeg_block_title\"><span>Kuzey K\u0131br\u0131s T\u00fcp Bebek&#039;te 50 Ya\u015f \u00dcst\u00fc Kad\u0131nlara T\u00fcp Bebek Tedavisi<\/span><\/h3>\n                <style>.jnews_module__0_69f55ee3f3314.jeg_block_heading_5 .jeg_block_title span, .jnews_module__0_69f55ee3f3314.jeg_block_heading_5 .jeg_block_title i { color: #7a7a7a; }<\/style>\n            <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ffff6dd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ffff6dd\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a3ccf12\" data-id=\"a3ccf12\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ef13f2 elementor-widget elementor-widget-jnews_post_feature_elementor\" data-id=\"6ef13f2\" data-element_type=\"widget\" data-widget_type=\"jnews_post_feature_elementor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"jeg_featured featured_image\"><a href=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women.jpg\"><div class=\"thumbnail-container animate-lazy\" style=\"padding-bottom:50%\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"375\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAP\/\/\/wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==\" class=\"attachment-jnews-750x375 size-jnews-750x375 lazyload wp-post-image\" alt=\"Ya\u015fl\u0131 Kad\u0131nlar \u0130\u00e7in 50 Ya\u015f \u00dcst\u00fc T\u00fcp Bebek\" sizes=\"(max-width: 750px) 100vw, 750px\" data-src=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women-750x375.jpg\" data-srcset=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women-750x375.jpg 750w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women-300x150.jpg 300w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women-768x384.jpg 768w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women-1024x512.jpg 1024w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women-360x180.jpg 360w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women.jpg 1140w\" data-sizes=\"auto\" data-expand=\"700\" \/><\/div><\/a><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5d8433c elementor-widget elementor-widget-text-editor\" data-id=\"5d8433c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-60d7772\" data-id=\"60d7772\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e0d5182 elementor-widget elementor-widget-text-editor\" data-id=\"e0d5182\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Otojen oositlerle gebelik istendi\u011finde ya\u015f kritik bir belirleyici fakt\u00f6rd\u00fcr. Anne ya\u015f\u0131 ilerledik\u00e7e, \u00f6ncelikle mayoz b\u00f6l\u00fcnme i\u011fnesinin dengesizli\u011fi, k\u00fcm\u00fclatif mitokondriyal disfonksiyon ve normal d\u00f6llenme ve erken embriyonik geli\u015fim i\u00e7in gerekli olan sitoplazmik organellerin ya\u015fa ba\u011fl\u0131 bozulmas\u0131 nedeniyle an\u00f6ploid oositlerin oran\u0131 katlanarak artar (Hassold ve Hunt, 2001; May-Panloup vd., 2016). Bu biyolojik de\u011fi\u015fiklikler, d\u00fc\u015f\u00fck d\u00f6llenme oranlar\u0131na, bozulmu\u015f embriyo geli\u015fimine ve belirgin \u015fekilde daha y\u00fcksek d\u00fc\u015f\u00fck oranlar\u0131na yol a\u00e7ar. Ba\u015far\u0131 oran\u0131 a\u00e7\u0131s\u0131ndan, \u00e7o\u011fu IVF program\u0131, hastan\u0131n kendi oositlerini kullanarak geleneksel IVF\/ICSI i\u00e7in 42-43 ya\u015f\u0131n\u0131 \u00fcst pratik s\u0131n\u0131r olarak kabul eder. Tedavi teknik olarak bu ya\u015f\u0131n \u00f6tesinde de sunulabilse de, \u00f6ploid bir embriyo ve canl\u0131 do\u011fum elde etme olas\u0131l\u0131\u011f\u0131 son derece d\u00fc\u015f\u00fck olur ve bu ger\u00e7ek, dan\u0131\u015fmanl\u0131k s\u0131ras\u0131nda a\u00e7\u0131k\u00e7a iletilmelidir (Sunkara vd., 2016).<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-662b935f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"662b935f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-286512d2\" data-id=\"286512d2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2a05571c elementor-widget elementor-widget-text-editor\" data-id=\"2a05571c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: justify;\">Yard\u0131mc\u0131 yakla\u015f\u0131mlar, \u00f6rne\u011fin <a href=\"https:\/\/www.lowcostivf.net\/tr\/prp-treatment\/\">yumurtal\u0131k trombosit a\u00e7\u0131s\u0131ndan zengin plazmas\u0131 (PRP)<\/a> Eksozom bazl\u0131 tedavilerle birlikte, primordial folik\u00fcl geli\u015fimini art\u0131rmay\u0131 ve intraovaryen mikroortam\u0131 iyile\u015ftirmeyi ama\u00e7layan yakla\u015f\u0131mlar ara\u015ft\u0131r\u0131lmaktad\u0131r. Bu m\u00fcdahaleler se\u00e7ilmi\u015f hastalarda yumurtal\u0131k aktivitesini ge\u00e7ici olarak iyile\u015ftirebilse de, etkinlikleri ya\u015f ilerledik\u00e7e azalmakta ve oosit yetene\u011findeki temel ya\u015fa ba\u011fl\u0131 d\u00fc\u015f\u00fc\u015f\u00fc tersine \u00e7evirememektedir (Sfakianoudis vd., 2019). Klinik deneyimlerimizde, yumurtal\u0131k PRP tedavisi sonras\u0131nda do\u011fal veya IVF destekli gebelik elde eden en ya\u015fl\u0131 hasta 47 ya\u015f\u0131ndayd\u0131; bu da ortaya \u00e7\u0131kan rejeneratif yakla\u015f\u0131mlara ra\u011fmen biyolojik s\u0131n\u0131rlar\u0131n devam etti\u011fini vurgulamaktad\u0131r. Bu nedenle, kabul edilebilir d\u00fczeyde primordial folik\u00fcl aktivitesine sahip hastalarda 47 ya\u015f\u0131na kadar yumurtal\u0131k PRP tedavisine anlaml\u0131 bir yan\u0131t beklenebilir.<\/p>\n<p style=\"text-align: justify;\">Yumurtal\u0131k trombosit a\u00e7\u0131s\u0131ndan zengin plazma (PRP) tedavileri klinik uygulamaya ilk girdi\u011finde, b\u00fcy\u00fck \u00f6l\u00e7\u00fcde Harvard&#039;a ba\u011fl\u0131 gruplar\u0131n erken deneysel \u00e7al\u0131\u015fmalar\u0131ndan kaynaklanan bask\u0131n hipotez, PRP&#039;nin yeti\u015fkin kad\u0131nlarda de novo oogenez yetene\u011fine sahip uykuda olan bir yumurtal\u0131k k\u00f6k h\u00fccre pop\u00fclasyonunu aktive edebilece\u011fiydi. Bu kavram, yumurtal\u0131k korteksinde mitotik olarak aktif germ hatt\u0131 k\u00f6k h\u00fccrelerinin varl\u0131\u011f\u0131n\u0131 ve bunlar\u0131n belirli uyar\u0131c\u0131 ko\u015fullar alt\u0131nda fonksiyonel oositlere farkl\u0131la\u015fma potansiyelini \u00f6ne s\u00fcren preklinik g\u00f6zlemlere dayan\u0131yordu (Johnson vd., 2004; White vd., 2012). Bununla birlikte, yumurtal\u0131k PRP&#039;sini klinik ortamda uygulamaya ba\u015flad\u0131\u011f\u0131m\u0131zda, biriken g\u00f6zlemler bu mekanizman\u0131n insanlarda bask\u0131n biyolojik yol olma olas\u0131l\u0131\u011f\u0131n\u0131n d\u00fc\u015f\u00fck oldu\u011funu g\u00f6sterdi. Bunun yerine, klinik ve laboratuvar bulgular\u0131, PRP maruziyetine birincil yan\u0131t verenlerin yeni aktive edilmi\u015f bir k\u00f6k h\u00fccre soyundan ziyade kal\u0131nt\u0131 primordial folik\u00fcller oldu\u011funu giderek daha fazla \u00f6ne s\u00fcrd\u00fc.<\/p>\n<p style=\"text-align: justify;\">Pratikte, yumurtal\u0131k PRP&#039;si uygulanan hastalarda, ger\u00e7ek k\u00f6k h\u00fccre g\u00fcd\u00fcml\u00fc oogenez ger\u00e7ekle\u015fiyorsa beklenece\u011fi gibi, s\u00fcrekli veya \u00fcstel folik\u00fcl olu\u015fumuna dair kan\u0131t bulunmam\u0131\u015ft\u0131r. Bunun yerine, AMH&#039;de ge\u00e7ici art\u0131\u015flar, menopoz \u00f6ncesi veya sonras\u0131 kad\u0131nlarda ara s\u0131ra adet kanamas\u0131n\u0131n yeniden ba\u015flamas\u0131 ve ultrasonografide s\u0131n\u0131rl\u0131 folik\u00fcl toplanmas\u0131 gibi g\u00f6zlemlenen de\u011fi\u015fiklikler, \u00f6nceden var olan primordial folik\u00fcllerin aktivasyonunun, hayatta kalmas\u0131n\u0131n veya senkronizasyonunun artmas\u0131yla daha tutarl\u0131d\u0131r (Sfakianoudis vd., 2019; Pantos vd., 2022). Mekanistik a\u00e7\u0131dan bak\u0131ld\u0131\u011f\u0131nda, bu durum, lokal anjiyogenezi iyile\u015ftirebilen, oksidatif stresi azaltabilen ve folik\u00fcl aktivasyonu ve erken folik\u00fclogenezde yer alan intra-ovaryen sinyal yollar\u0131n\u0131 mod\u00fcle edebilen PDGF, VEGF, TGF-\u03b2 ve IGF-1 gibi b\u00fcy\u00fcme fakt\u00f6rlerinin iletimini i\u00e7eren PRP&#039;nin bilinen biyolojik etkileriyle uyumludur (Marx, 2004; Kawamura vd., 2013).<\/p>\n<p style=\"text-align: justify;\">Bu g\u00f6zlemler, yumurtal\u0131k PRP&#039;sinin \u00f6ncelikle yumurtal\u0131k rezervini yenileyebilen ger\u00e7ek bir rejeneratif tedavi olmaktan ziyade mikro\u00e7evresel bir mod\u00fclat\u00f6r olarak i\u015flev g\u00f6rebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Stromal deste\u011fi, vask\u00fclarizasyonu ve lokal sitokin dengesini iyile\u015ftirerek, PRP, halihaz\u0131rda mevcut olan ancak fonksiyonel olarak hareketsiz olan folik\u00fcllerin olu\u015fumunu veya olgunla\u015fmas\u0131n\u0131 kolayla\u015ft\u0131rabilir. Bu ayr\u0131m klinik a\u00e7\u0131dan \u00f6nemlidir, \u00e7\u00fcnk\u00fc hem PRP yan\u0131tlar\u0131n\u0131n s\u0131n\u0131rl\u0131 b\u00fcy\u00fckl\u00fc\u011f\u00fcn\u00fc hem de ya\u015fa ba\u011fl\u0131 do\u011fas\u0131n\u0131 a\u00e7\u0131klar ve yumurtal\u0131k PRP&#039;sinin ileri yumurtal\u0131k ya\u015flanmas\u0131n\u0131n veya \u015fiddetli folik\u00fcl t\u00fckenmesinin getirdi\u011fi temel k\u0131s\u0131tlamalar\u0131n \u00fcstesinden gelememesinin nedenini vurgular. Sonu\u00e7 olarak, PRP, yeti\u015fkin insan yumurtal\u0131klar\u0131nda ger\u00e7ek neo-oogenezi ind\u00fckleme y\u00f6ntemi olarak g\u00f6r\u00fclmemelidir.<\/p>\n<p style=\"text-align: justify;\">Benzer \u015fekilde, mitokondriyal replasman tedavisi (MRT) gibi geli\u015fmi\u015f teknikler veya <a href=\"https:\/\/www.lowcostivf.net\/tr\/cytoplasmic-ivf\/\">Sitoplazmik transfer ile IVF<\/a> Olgun (MII) oositlerin bulunabilirli\u011fine hala ihtiya\u00e7 duyulmaktad\u0131r ve bu nedenle yumurtal\u0131k ya\u015flanmas\u0131 ve kalan oosit kalitesiyle s\u0131n\u0131rl\u0131 kalmaktad\u0131r (Zhang ve ark., 2017).<\/p>\n<p style=\"text-align: justify;\">Bu nedenle, menopoza hen\u00fcz girmemi\u015f, d\u00fczenli adet g\u00f6ren ve bir miktar kal\u0131nt\u0131 yumurtal\u0131k aktivitesi g\u00f6steren hastalarda bile, otolog oositlerle gebelik elde etme olas\u0131l\u0131\u011f\u0131 47-48 ya\u015f\u0131ndan sonra keskin bir \u015fekilde azal\u0131r. Bu a\u015famada, s\u0131n\u0131rlay\u0131c\u0131 fakt\u00f6r sadece yumurtal\u0131k fonksiyonu de\u011fil, oosit yeterlili\u011fidir; \u00e7\u00fcnk\u00fc ya\u015fa ba\u011fl\u0131 mayoz hatalar\u0131, mitokondriyal disfonksiyon ve k\u00fcm\u00fclatif DNA hasar\u0131, kalan oositlerin geli\u015fim potansiyelini \u00f6nemli \u00f6l\u00e7\u00fcde bozar. Yumurtal\u0131k PRP&#039;si, sitoplazmik transfer veya mitokondriyal replasman teknikleri gibi geli\u015fmi\u015f ve deneysel m\u00fcdahaleler, yumurtal\u0131k veya sitoplazmik ortam\u0131 m\u00fctevaz\u0131 bir \u015fekilde optimize edebilse de, oosit ya\u015flanmas\u0131n\u0131n getirdi\u011fi temel biyolojik k\u0131s\u0131tlamalar\u0131n \u00fcstesinden tam olarak gelemezler. Sonu\u00e7 olarak, bu ya\u015ftan sonra kendi yumurtalar\u0131yla canl\u0131, \u00f6ploid bir embriyo ve s\u00fcrd\u00fcr\u00fclebilir bir gebelik elde etme olas\u0131l\u0131\u011f\u0131 son derece d\u00fc\u015f\u00fckt\u00fcr ve bu ger\u00e7ek, bilgilendirilmi\u015f ve ger\u00e7ek\u00e7i karar vermeyi desteklemek i\u00e7in hasta dan\u0131\u015fmanl\u0131\u011f\u0131 s\u0131ras\u0131nda a\u00e7\u0131k\u00e7a ele al\u0131nmal\u0131d\u0131r.<\/p>\n<p style=\"text-align: justify;\">Buna kar\u015f\u0131l\u0131k, don\u00f6r yumurtalar kullan\u0131larak elde edilen gebelik sonu\u00e7lar\u0131, uterusun hormonal olarak haz\u0131r olmas\u0131 ve hastan\u0131n t\u0131bbi olarak gebeli\u011fe uygun olmas\u0131 ko\u015fuluyla, al\u0131c\u0131n\u0131n kronolojik ya\u015f\u0131ndan b\u00fcy\u00fck \u00f6l\u00e7\u00fcde ba\u011f\u0131ms\u0131zd\u0131r. Kuzey K\u0131br\u0131s T\u00fcp Bebek Merkezi&#039;nde, <a href=\"https:\/\/www.lowcostivf.net\/tr\/ivf-with-donor-eggs1\/\">Don\u00f6r yumurtalar\u0131yla IVF<\/a> Don\u00f6r yumurta ile t\u00fcp bebek tedavisi, 50 ya\u015f \u00fcst\u00fc kad\u0131nlara rutin olarak sunulmakta olup, yasal tedavi s\u0131n\u0131r\u0131 56 ya\u015ft\u0131r. Bu ya\u015fa kadar tedavi, ek bir d\u00fczenleyici onay gerektirmeden sa\u011flanabilir. 56 ya\u015f\u0131ndan sonra vakalar bireysel olarak de\u011ferlendirilir ve Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131&#039;ndan izin al\u0131nmas\u0131 gerekir. 50 ya\u015f \u00fcst\u00fc kad\u0131nlarda don\u00f6r yumurta ile t\u00fcp bebek tedavisinin ba\u015far\u0131s\u0131 iyi bir \u015fekilde belgelenmi\u015ftir; implantasyon ve canl\u0131 do\u011fum oranlar\u0131, daha gen\u00e7 al\u0131c\u0131larla kar\u015f\u0131la\u015ft\u0131r\u0131labilir d\u00fczeydedir ve bu da \u00fcreme sonu\u00e7lar\u0131nda rahim ya\u015f\u0131 yerine yumurta ya\u015f\u0131n\u0131n bask\u0131n rol\u00fcn\u00fc yans\u0131tmaktad\u0131r (Paulson vd., 2002; Sauer, 2015).<\/p>\n<p style=\"text-align: justify;\"><a><img decoding=\"async\" style=\"width: auto; max-width: 100%;\" src=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/10\/cytoplasmic-ivf-transfer_orig.jpg\" alt=\"45 ve 50 ya\u015f \u00fcst\u00fc t\u00fcp bebek gebelikleri\"><\/a><\/p>\n<p style=\"text-align: justify;\">Y\u00fcksek kaliteli do\u011furganl\u0131k tedavisi, etkili ileti\u015fim, bireyselle\u015ftirilmi\u015f t\u0131bbi karar verme ve empatiyi kapsar; bunlar\u0131n hepsi hastalar\u0131n beklentilerini, de\u011ferlerini ve duygusal iyilik hallerini ele almak i\u00e7in gereklidir. Yasal veya etik k\u0131s\u0131tlamalar zaman zaman mevcut se\u00e7enekleri s\u0131n\u0131rlayabilse de, hastalar ve klinisyenler aras\u0131nda \u015feffaf diyalog genellikle kar\u015f\u0131l\u0131kl\u0131 olarak kabul edilebilir ve t\u0131bbi a\u00e7\u0131dan do\u011fru \u00e7\u00f6z\u00fcmlere olanak tan\u0131r.<\/p>\n<p style=\"text-align: justify;\">Ya\u015f, t\u00fcp bebek (IVF) mevzuat\u0131 ve klinik uygulamas\u0131 kesi\u015fiminde en \u00e7ok tart\u0131\u015f\u0131lan fakt\u00f6rlerden biri olmaya devam etmektedir. Bir\u00e7ok do\u011furganl\u0131k merkezi, \u00fclkeler aras\u0131nda b\u00fcy\u00fck farkl\u0131l\u0131klar g\u00f6steren, bazen 42 ya\u015f kadar d\u00fc\u015f\u00fck, bazen de 50 ya\u015f ve \u00fczeri olan yasal veya kurumsal ya\u015f s\u0131n\u0131rlar\u0131 uygulamaktad\u0131r. \u00d6zellikle, bu k\u0131s\u0131tlamalar\u0131n \u00e7o\u011fu, objektif t\u0131bbi kontrendikasyonlardan ziyade etik veya toplumsal kayg\u0131lardan kaynaklanmaktad\u0131r. T\u0131bbi a\u00e7\u0131dan bak\u0131ld\u0131\u011f\u0131nda, do\u011furganl\u0131k tedavisi bir sa\u011fl\u0131k hizmeti m\u00fcdahalesidir ve \u00f6ncelikle anne sa\u011fl\u0131\u011f\u0131 ve gebelik riskinin kan\u0131ta dayal\u0131 de\u011ferlendirmesiyle y\u00f6nlendirilmelidir. Bir kad\u0131n kapsaml\u0131 bir \u015fekilde de\u011ferlendirilip t\u0131bbi olarak uygun bulundu\u011fu takdirde, kronolojik ya\u015f tek ba\u015f\u0131na tedaviye mutlak bir engel te\u015fkil etmemelidir (ESHRE, 2015).<\/p>\n<p style=\"text-align: justify;\">Kad\u0131n \u00fcreme sisteminin ya\u015flanmas\u0131 ya\u015fam\u0131n erken d\u00f6nemlerinde ba\u015flar. Yumurtal\u0131k rezervi fetal geli\u015fim s\u0131ras\u0131nda olu\u015fur ve tahmini olarak birka\u00e7 milyon oositlik bir zirveye ula\u015f\u0131r; bu oositler daha sonra s\u00fcrekli olarak azal\u0131r. Ergenlikten itibaren folik\u00fcl kayb\u0131 h\u0131zlan\u0131r ve 30 ya\u015f\u0131nda orijinal rezervin yakla\u015f\u0131k 101 TP3T&#039;si, 40 ya\u015f\u0131nda ise 31 TP3T&#039;den daha az\u0131 kal\u0131r (Wallace ve Kelsey, 2010). Oosit miktar\u0131 ve kalitesi keskin bir \u015fekilde azal\u0131rken, rahim al\u0131c\u0131l\u0131\u011f\u0131 ya\u015fla birlikte b\u00fcy\u00fck \u00f6l\u00e7\u00fcde korunur ve don\u00f6r oositler kullan\u0131ld\u0131\u011f\u0131nda daha ya\u015fl\u0131 kad\u0131nlarda ba\u015far\u0131l\u0131 gebeliklere olanak tan\u0131r. Bu ayr\u0131m, menopoz sonras\u0131 kad\u0131nlara don\u00f6r yumurta IVF&#039;si sunman\u0131n gerek\u00e7esini desteklemektedir.<\/p>\n<p style=\"text-align: justify;\">Son on y\u0131llarda ya\u015fam beklentisi ve genel sa\u011fl\u0131k durumu \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015fmi\u015ftir. Avrupa&#039;da ortalama kad\u0131n ya\u015fam beklentisi art\u0131k 82 y\u0131l\u0131 a\u015fmaktad\u0131r ve ya\u015fa ba\u011fl\u0131 bir\u00e7ok t\u0131bbi durum modern t\u0131bbi bak\u0131m ile etkili bir \u015fekilde y\u00f6netilmektedir. 50 ya\u015f \u00fcst\u00fc kad\u0131nlarda gebeliklerle ilgili mevcut kan\u0131tlar, hastalar dikkatlice taran\u0131p izlendi\u011finde orant\u0131s\u0131z bir anne riski g\u00f6stermemektedir (Sauer, 2015). Gen\u00e7 don\u00f6r yumurtalar\u0131n\u0131n kullan\u0131m\u0131yla yavrulara y\u00f6nelik genetik riskler b\u00fcy\u00fck \u00f6l\u00e7\u00fcde azalt\u0131lmaktad\u0131r ve menopozun kendisi art\u0131k \u00fcreme yetersizli\u011finin mutlak bir g\u00f6stergesi olarak g\u00f6r\u00fclmemelidir; t\u0131pk\u0131 gen\u00e7 kad\u0131nlarda erken menopozun do\u011furganl\u0131k tedavisine bir kontrendikasyon olarak kabul edilmemesi gibi.<\/p><p style=\"text-align: justify;\">Kuzey K\u0131br\u0131s T\u00fcp Bebek Merkezi&#039;nde, 50 ya\u015f \u00fcst\u00fc kad\u0131nlar i\u00e7in k\u0131s\u0131rl\u0131k tedavisi, keyfi ya\u015f s\u0131n\u0131rlar\u0131 yerine bireyselle\u015ftirilmi\u015f t\u0131bbi de\u011ferlendirmeye dayal\u0131 olarak sunulmaktad\u0131r. Yakla\u015f\u0131m\u0131m\u0131z, titiz t\u0131bbi standartlar\u0131 korurken ya\u015fa dayal\u0131 ayr\u0131mc\u0131l\u0131\u011f\u0131 ortadan kald\u0131rmay\u0131 ama\u00e7lamaktad\u0131r. T\u00fcm adaylar, hematolojik, renal, hepatik, metabolik ve hormonal testlerin yan\u0131 s\u0131ra elektrokardiyografi ve ekokardiyogram ile kardiyovask\u00fcler tarama da dahil olmak \u00fczere kapsaml\u0131 bir de\u011ferlendirmeden ge\u00e7erler. Kontrol alt\u0131na al\u0131nmam\u0131\u015f hipertansiyon, diyabet veya \u00f6nemli kalp hastal\u0131\u011f\u0131 gibi gebelikle k\u00f6t\u00fcle\u015febilecek durumlar, kronolojik ya\u015ftan ba\u011f\u0131ms\u0131z olarak kontrendikasyon olarak kabul edilir. Hastalara ayr\u0131ca, daha ya\u015fl\u0131 ya\u015f gruplar\u0131nda gebelikle ilgili komplikasyon olas\u0131l\u0131\u011f\u0131n\u0131n artmas\u0131 ve yo\u011funla\u015ft\u0131r\u0131lm\u0131\u015f do\u011fum \u00f6ncesi izlemenin gereklili\u011fi konusunda kapsaml\u0131 bir \u015fekilde dan\u0131\u015fmanl\u0131k yap\u0131l\u0131r.<\/p>\n<p style=\"text-align: justify;\">50 ya\u015f \u00fcst\u00fc kad\u0131nlar i\u00e7in, do\u011furganl\u0131k tedavisi se\u00e7enekleri yumurtal\u0131k biyolojisi nedeniyle s\u0131n\u0131rl\u0131d\u0131r. Eksozomlu yumurtal\u0131k PRP&#039;si, bu ya\u015f grubunda s\u0131n\u0131rl\u0131 kan\u0131t bulunan ve deneysel bir m\u00fcdahale olarak ele al\u0131nmas\u0131 gereken bir y\u00f6ntemdir. Buna kar\u015f\u0131l\u0131k, don\u00f6r yumurtalarla yap\u0131lan IVF, y\u00fcksek ba\u015far\u0131 oranlar\u0131 ve iyi bilinen g\u00fcvenlik profilleri sunan alt\u0131n standart olmaya devam etmektedir. Bu ba\u011flamda, karar verme s\u00fcrecinde yaln\u0131zca ya\u015f de\u011fil, t\u0131bbi de\u011ferlendirme de yol g\u00f6sterici olmal\u0131 ve do\u011furganl\u0131k bak\u0131m\u0131n\u0131n etik, kan\u0131ta dayal\u0131 ve hasta merkezli olmas\u0131 sa\u011flanmal\u0131d\u0131r.<\/p>\n<p style=\"text-align: justify;\">Tedavilerimiz hakk\u0131nda daha fazla bilgi i\u00e7in l\u00fctfen&nbsp;<strong><a href=\"\/tr\/contact\/\">bize Ula\u015f\u0131n<\/a><\/strong>!<\/p>\n<p style=\"text-align: justify;\">Bu bilgiyi ba\u015fkalar\u0131yla payla\u015f\u0131n!<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c30ef5e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c30ef5e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d98454f\" data-id=\"d98454f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-02ea96b elementor-widget elementor-widget-jnews_post_share_elementor\" data-id=\"02ea96b\" data-element_type=\"widget\" data-widget_type=\"jnews_post_share_elementor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class='jeg_custom_share_wrapper'><div class=\"jeg_share_top_container\"><div class=\"jeg_share_button clearfix\">\n                <div class=\"jeg_share_stats\">\n                    \n                    \n                <\/div>\n                <div class=\"jeg_sharelist\">\n                    <a href=\"http:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.lowcostivf.net%2Ftr%2Fivf-over-50-for-older-women%2F\" rel='nofollow'  class=\"jeg_btn-facebook expanded\"><i class=\"fa fa-facebook-official\"><\/i><span>Facebook&#039;ta Payla\u015f<\/span><\/a><a href=\"https:\/\/twitter.com\/intent\/tweet?text=IVF+Over+50+For+Older+Women&url=https%3A%2F%2Fwww.lowcostivf.net%2Ftr%2Fivf-over-50-for-older-women%2F\" rel='nofollow'  class=\"jeg_btn-twitter expanded\"><i class=\"fa fa-twitter\"><\/i><span>Twitter&#039;da payla\u015f<\/span><\/a>\n                    <div class=\"share-secondary\">\n                    <a href=\"https:\/\/www.linkedin.com\/shareArticle?url=https%3A%2F%2Fwww.lowcostivf.net%2Ftr%2Fivf-over-50-for-older-women%2F&title=IVF+Over+50+For+Older+Women\" rel='nofollow'  class=\"jeg_btn-linkedin\"><i class=\"fa fa-linkedin\"><\/i><\/a><a href=\"https:\/\/www.pinterest.com\/pin\/create\/bookmarklet\/?pinFave=1&url=https%3A%2F%2Fwww.lowcostivf.net%2Ftr%2Fivf-over-50-for-older-women%2F&media=https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-over-50-for-older-women.jpg&description=IVF+Over+50+For+Older+Women\" rel='nofollow'  class=\"jeg_btn-pinterest\"><i class=\"fa fa-pinterest\"><\/i><\/a><a href=\"http:\/\/www.stumbleupon.com\/submit?url=https%3A%2F%2Fwww.lowcostivf.net%2Ftr%2Fivf-over-50-for-older-women%2F&title=IVF+Over+50+For+Older+Women\" rel='nofollow'  class=\"jeg_btn-stumbleupon\"><i class=\"fa fa-stumbleupon\"><\/i><\/a><a href=\"https:\/\/reddit.com\/submit?url=https%3A%2F%2Fwww.lowcostivf.net%2Ftr%2Fivf-over-50-for-older-women%2F&title=IVF+Over+50+For+Older+Women\" rel='nofollow'  class=\"jeg_btn-reddit\"><i class=\"fa fa-reddit\"><\/i><\/a><a href=\"https:\/\/www.tumblr.com\/widgets\/share\/tool?canonicalUrl=https%3A%2F%2Fwww.lowcostivf.net%2Ftr%2Fivf-over-50-for-older-women%2F&title=IVF+Over+50+For+Older+Women\" rel='nofollow'  class=\"jeg_btn-tumbrl\"><i class=\"fa fa-tumblr\"><\/i><\/a><a href=\"mailto:?subject=IVF Over 50 For Older Women&amp;body=https:\/\/www.lowcostivf.net\/tr\/ivf-over-50-for-older-women\/\" rel='nofollow'  class=\"jeg_btn-email\"><i class=\"fa fa-envelope\"><\/i><\/a><a href=\"\/\/api.whatsapp.com\/send?text=IVF Over 50 For Older Women\nhttps:\/\/www.lowcostivf.net\/tr\/ivf-over-50-for-older-women\/\" rel='nofollow'  data-action=\"share\/whatsapp\/share\"  class=\"jeg_btn-whatsapp\"><i class=\"fa fa-whatsapp\"><\/i><\/a><a href=\"https:\/\/social-plugins.line.me\/lineit\/share?url=https%3A%2F%2Fwww.lowcostivf.net%2Ftr%2Fivf-over-50-for-older-women%2F&text=IVF+Over+50+For+Older+Women\" rel='nofollow'  class=\"jeg_btn-line\"><i class=\"fa fa-line\"><\/i><\/a>\n                <\/div>\n                <a href=\"#\" class=\"jeg_btn-toggle\"><i class=\"fa fa-share\"><\/i><\/a>\n                <\/div>\n            <\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Kuzey K\u0131br\u0131s IVF&#039;de 50 ya\u015f \u00fcst\u00fc kad\u0131nlar i\u00e7in IVF tedavisi. Resim boyutu: 750\u00d7375. Otolog oositlerle gebelik istendi\u011finde ya\u015f kritik bir belirleyicidir. Anne ya\u015f\u0131 ilerledik\u00e7e, \u00f6ncelikle mayoz b\u00f6l\u00fcnme i\u011fnesinin dengesizli\u011fi, k\u00fcm\u00fclatif mitokondriyal disfonksiyon ve sitoplazmik organellerin ya\u015fa ba\u011fl\u0131 bozulmas\u0131 nedeniyle an\u00f6ploid oositlerin oran\u0131 katlanarak artar. [\u2026]<\/p>","protected":false},"author":1,"featured_media":1493,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-705","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>IVF for Women over 50 - Is it Possible? - North Cyprus IVF<\/title>\n<meta name=\"description\" content=\"North Cyprus IVF Centre offers IVF treatment for older women over 50 years of age as long as the patient is found medically fit for pregnancy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lowcostivf.net\/tr\/ivf-over-50-for-older-women\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IVF for Women over 50 - Is it Possible? 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