{"id":702,"date":"2019-10-27T11:29:18","date_gmt":"2019-10-27T11:29:18","guid":{"rendered":"https:\/\/www.lowcostivf.net\/ivf-failures\/"},"modified":"2024-12-26T16:19:45","modified_gmt":"2024-12-26T16:19:45","slug":"ivf-failures","status":"publish","type":"page","link":"https:\/\/www.lowcostivf.net\/tr\/ivf-failures\/","title":{"rendered":"T\u00fcp Bebek Ba\u015far\u0131s\u0131zl\u0131klar\u0131"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"702\" class=\"elementor elementor-702\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-423eddf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"423eddf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6266de0\" data-id=\"6266de0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cade527 elementor-widget elementor-widget-jnews_element_header_elementor\" data-id=\"cade527\" data-element_type=\"widget\" data-widget_type=\"jnews_element_header_elementor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg_block_heading jeg_block_heading_5 jeg_aligncenter jnews_module__0_69f926d2d3320\">\n                <h3 class=\"jeg_block_title\"><span>T\u00fcp Bebek D\u00f6ng\u00fcs\u00fcn\u00fcn Ba\u015far\u0131s\u0131z Olmas\u0131n\u0131n Nedenleri Nelerdir?<\/span><\/h3>\n                <style>.jnews_module__0_69f926d2d3320.jeg_block_heading_5 .jeg_block_title span, .jnews_module__0_69f926d2d3320.jeg_block_heading_5 .jeg_block_title i { color: #7a7a7a; }<\/style>\n            <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2c9a533 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2c9a533\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-99d4ab4\" data-id=\"99d4ab4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2382df7 elementor-widget elementor-widget-image\" data-id=\"2382df7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"384\" src=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-failures-768x384.jpg\" class=\"attachment-medium_large size-medium_large wp-image-1526\" alt=\"\" srcset=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-failures-768x384.jpg 768w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-failures-300x150.jpg 300w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-failures-1024x512.jpg 1024w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-failures-360x180.jpg 360w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-failures-750x375.jpg 750w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-failures.jpg 1140w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2652b2c\" data-id=\"2652b2c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-41d8d24 related_topics elementor-widget elementor-widget-text-editor\" data-id=\"41d8d24\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"color: white !important;\">\u0130lgili konular<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b61f25e elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"b61f25e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/female-infertility\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Kad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131n\u0131n Nedenleri ve Tedavisi<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a7d0644 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"a7d0644\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/male-infertility\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Erkek K\u0131s\u0131rl\u0131\u011f\u0131n\u0131n Nedenleri ve Tedavisi<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef284e9 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"ef284e9\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/testing\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">K\u0131s\u0131rl\u0131k Testi ve Te\u015fhisi<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-43c5ec8 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"43c5ec8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/ivf-failures\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Tekrarlanan T\u00fcp Bebek Ba\u015far\u0131s\u0131zl\u0131klar\u0131<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d9c674 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"7d9c674\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/miscarriages\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Tekrarlayan D\u00fc\u015f\u00fckler<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4ca39737 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4ca39737\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-733f6ae7\" data-id=\"733f6ae7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a9f1ca8 elementor-widget elementor-widget-text-editor\" data-id=\"7a9f1ca8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>IVF, yard\u0131mc\u0131 \u00fcreme teknolojilerinin (ART) temel ta\u015f\u0131 haline gelerek k\u0131s\u0131rl\u0131kla kar\u015f\u0131 kar\u015f\u0131ya kalan \u00e7iftlere umut sunmaktad\u0131r. Ancak, birden fazla IVF d\u00f6ng\u00fcs\u00fcnden sonra klinik bir gebelik elde edememek \u00f6nemli duygusal, fiziksel ve finansal strese neden olabilir. Genellikle \u00fc\u00e7 veya daha fazla ba\u015far\u0131s\u0131z d\u00f6ng\u00fc olarak tan\u0131mlanan tekrarlayan IVF ba\u015far\u0131s\u0131zl\u0131\u011f\u0131, altta yatan nedenleri belirlemek i\u00e7in kapsaml\u0131 bir de\u011ferlendirme gerektirir (Zegers-Hochschild ve di\u011ferleri, 2017).<\/p>\n<p>Herhangi bir do\u011furganl\u0131k tedavisinin amac\u0131 olumlu bir sonu\u00e7 elde etmek olsa da, baz\u0131 tedavilerin ba\u015far\u0131s\u0131z olabilece\u011fini kabul etmek de \u00f6nemlidir. Bir ba\u015far\u0131s\u0131zl\u0131kla kar\u015f\u0131 kar\u015f\u0131ya kald\u0131\u011f\u0131n\u0131zda, duygulara kap\u0131lmak ve bunalt\u0131c\u0131 olumsuz d\u00fc\u015f\u00fcncelere sahip olmak kolayd\u0131r. Ancak, ak\u0131lda tutulmas\u0131 gereken \u00f6nemli bir \u015fey, bazen ba\u015far\u0131s\u0131z bir IVF d\u00f6ng\u00fcs\u00fcnden sonra, daha sonra daha etkili bir tedaviye yol a\u00e7acak ipu\u00e7lar\u0131 bulman\u0131n m\u00fcmk\u00fcn olabilece\u011fidir. K\u0131s\u0131rl\u0131k testi, do\u011furganl\u0131k durumunuz hakk\u0131nda \u00e7ok iyi bir resim sa\u011flasa da, yumurtal\u0131klar\u0131n\u0131z\u0131n belirli ila\u00e7lara nas\u0131l yan\u0131t verece\u011fini veya yumurtalar\u0131n kalitesinin nas\u0131l olaca\u011f\u0131n\u0131 her zaman ba\u015far\u0131l\u0131 bir \u015fekilde tahmin edemeyebilir. Ba\u015far\u0131s\u0131z bir IVF d\u00f6ng\u00fcs\u00fc, moral bozucu olsa da, IVF uzman\u0131n\u0131za yumurtal\u0131k tepkiniz, yumurta kaliteniz, d\u00f6llenme oranlar\u0131n\u0131z ve embriyo kaliteniz gibi son derece yararl\u0131 bilgiler sa\u011flayabilir. G\u00f6zlemlenen bu \u00f6zelliklere dayanarak, tedavinizin neden ba\u015far\u0131s\u0131z olabilece\u011fini a\u00e7\u0131klayabilecek sorunu veya sorunlar\u0131 d\u00fczeltmek amac\u0131yla gelecekteki bir d\u00f6ng\u00fc daha kapsaml\u0131 bir \u015fekilde planlanabilir.<\/p>\n<p>Ba\u015far\u0131s\u0131z bir IVF d\u00f6ng\u00fcs\u00fcnden sonra, IVF uzman\u0131n\u0131z\u0131n dosyan\u0131z\u0131 incelemesi ve \u00f6nceki test sonu\u00e7lar\u0131n\u0131 ba\u015far\u0131s\u0131z d\u00f6ng\u00fcn\u00fcn ayr\u0131nt\u0131lar\u0131yla ili\u015fkilendirmesi \u00f6nemli olacakt\u0131r. \u00d6l\u00e7\u00fclen d\u00f6ng\u00fc sonu\u00e7lar\u0131n\u0131n d\u00f6ng\u00fc \u00f6ncesi k\u0131s\u0131rl\u0131k de\u011ferlendirmesiyle uyumlu olup olmad\u0131\u011f\u0131n\u0131 g\u00f6rmek esast\u0131r. D\u00f6ng\u00fc \u00f6ncesi beklentiler \u00f6l\u00e7\u00fclen d\u00f6ng\u00fc sonu\u00e7lar\u0131yla (yumurta say\u0131s\u0131, yumurta kalitesi, sperm kalitesi, d\u00f6llenme oranlar\u0131, b\u00f6l\u00fcnme embriyo olu\u015fumu oranlar\u0131, blastosist embriyo olu\u015fumu oranlar\u0131 gibi) kar\u015f\u0131lanmad\u0131ysa, IVF uzman\u0131n\u0131z tutars\u0131zl\u0131\u011f\u0131 a\u00e7\u0131klayabilmek i\u00e7in ek testler isteyebilir.<\/p>\n<p>Tekrarlayan t\u00fcp bebek (IVF) ba\u015far\u0131s\u0131zl\u0131klar\u0131 \u00fcreme t\u0131bb\u0131nda \u00f6nemli bir zorluk olmaya devam ediyor. Tekniklerdeki ilerlemelere ra\u011fmen, bir hastan\u0131n neden tekrarlayan t\u00fcp bebek ba\u015far\u0131s\u0131zl\u0131klar\u0131 ya\u015fayabilece\u011fini anlamak, baz\u0131 geli\u015fmi\u015f testlerle bile cevaplanmas\u0131 kolay bir soru de\u011fil. Embriyolojik, uterin ve sistemik fakt\u00f6rlerin yan\u0131 s\u0131ra erkek katk\u0131lar\u0131 ve d\u0131\u015f etkenleri kapsayan t\u00fcp bebek ba\u015far\u0131s\u0131zl\u0131klar\u0131n\u0131n baz\u0131 birincil nedenlerini inceleyece\u011fiz.<\/p>\n<h4><strong>1. <span style=\"text-decoration: underline;\">Embriyolojik ve Laboratuvar Fakt\u00f6rleri<\/span><\/strong><\/h4>\n<p><strong><br>1.1. D\u00fc\u015f\u00fck Embriyo Kalitesi<\/strong><\/p>\n<p>Embriyo kalitesi IVF ba\u015far\u0131s\u0131 i\u00e7in \u00e7ok \u00f6nemlidir. Aneuploidi gibi embriyolardaki genetik anomaliler yayg\u0131nd\u0131r ve anne ya\u015f\u0131yla birlikte artar (Fragouli &amp; Wells, 2012). Aneuploidi i\u00e7in morfolojik de\u011ferlendirmeler ve implantasyon \u00f6ncesi genetik testler (PGT-A) i\u00e7g\u00f6r\u00fc sa\u011flayabilir, ancak morfolojik olarak normal embriyolar bile genetik kusurlara sahip olabilir (Alfarawati ve di\u011ferleri, 2011). Embriyo kalitesi, geli\u015fimsel potansiyeli, genetik b\u00fct\u00fcnl\u00fc\u011f\u00fc ve rahim astar\u0131na yerle\u015fme yetene\u011fi ile belirlenir.<\/p>\n<p>\u00c7ok yava\u015f veya \u00e7ok h\u0131zl\u0131 geli\u015fen embriyolar genellikle d\u00fc\u015f\u00fck kaliteli olarak kabul edilir. \u00d6rne\u011fin, 5. g\u00fcne kadar blastosist a\u015famas\u0131na ula\u015fmayan bir embriyonun canl\u0131l\u0131\u011f\u0131 azalm\u0131\u015f olabilir. Bu asenkroni, embriyonun geli\u015fim a\u015famas\u0131 ile rahim astar\u0131n\u0131n al\u0131c\u0131l\u0131\u011f\u0131 aras\u0131nda uyumsuzlu\u011fa yol a\u00e7arak implantasyon ba\u015far\u0131s\u0131zl\u0131\u011f\u0131na neden olabilir.<\/p>\n<p>D\u00fc\u015f\u00fck kaliteli embriyolar\u0131n kromozomal anormalliklere sahip olma olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir (\u00f6rne\u011fin, yanl\u0131\u015f say\u0131da kromozom bulunan aneuploidi). Aneuploidili embriyolar genellikle do\u011fru \u015fekilde b\u00f6l\u00fcnemez ve bu da geli\u015fimde durmaya veya implantasyon ba\u015far\u0131s\u0131zl\u0131\u011f\u0131na yol a\u00e7ar. \u0130mplantasyon ger\u00e7ekle\u015fse bile, kromozomal anormallikler erken gebelik kayb\u0131n\u0131n ba\u015fl\u0131ca nedenidir. Yap\u0131sal veya genetik anormallikleri olan embriyolar genellikle rahim astar\u0131na yap\u0131\u015famaz. Bu, gebeli\u011fin kurulmas\u0131nda kritik bir ad\u0131md\u0131r. K\u00f6t\u00fc morfolojiye (anormal h\u00fccre boyutu, par\u00e7alanma veya zay\u0131f tan\u0131mlanm\u0131\u015f i\u00e7 h\u00fccre k\u00fctlesi) sahip blastosist a\u015famas\u0131ndaki embriyolar\u0131n ba\u015far\u0131l\u0131 bir \u015fekilde implante olma olas\u0131l\u0131\u011f\u0131 daha d\u00fc\u015f\u00fckt\u00fcr. Embriyolar\u0131n kromozomal anormallikler a\u00e7\u0131s\u0131ndan taranmas\u0131, embriyo transferi i\u00e7in uygulanabilir embriyolar\u0131n se\u00e7imini iyile\u015ftirebilir ve kromozomal sorunlar\u0131 olabilecek embriyolar\u0131n transfer edilme olas\u0131l\u0131\u011f\u0131n\u0131 azaltabilir. Daha fazla bilgi i\u00e7in &quot;<a href=\"https:\/\/www.lowcostivf.net\/tr\/pre-implantation-genetic-diagnosis-pgd\/\">\u0130mplantasyon \u00d6ncesi Genetik Test<\/a>&quot; sayfa.<\/p>\n<p>Par\u00e7alanma, embriyo kalitesi s\u00f6z konusu oldu\u011funda da bir endi\u015fe kayna\u011f\u0131 olabilir. Par\u00e7alanma, h\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda embriyonun i\u00e7inde olu\u015fan k\u00fc\u00e7\u00fck h\u00fccresel art\u0131k par\u00e7alar\u0131na at\u0131fta bulunur. Y\u00fcksek par\u00e7alanma oranlar\u0131, embriyonun genel kalitesini d\u00fc\u015f\u00fcrerek normal h\u00fccresel ileti\u015fimi ve i\u015flevi engeller.<\/p>\n<p>D\u00fc\u015f\u00fck kaliteli embriyolar, genel olarak, b\u00f6l\u00fcnmek ve ya\u015fayabilir bir fet\u00fcse d\u00f6n\u00fc\u015fmek i\u00e7in gerekli h\u00fccresel makine ve enerjiden yoksun olabilir. Buna, geli\u015fim s\u0131ras\u0131nda suboptimal mitokondriyal fonksiyon veya yetersiz epigenetik programlama dahildir. Bazen, geli\u015fmekte olan bir embriyoda yap\u0131sal sorunlar g\u00f6zlemlenebilir. \u00d6rne\u011fin, zona pellucida (embriyo d\u0131\u015f kabu\u011fu) \u00e7ok kal\u0131n olabilir ve yumurtadan \u00e7\u0131kmay\u0131 ve implantasyonu engelleyebilir. \u0130\u00e7 h\u00fccre k\u00fctlesindeki veya trofektodermdeki (plasentay\u0131 olu\u015fturan embriyonun par\u00e7as\u0131) anormallikler de embriyonun implante olma ve gebeli\u011fi s\u00fcrd\u00fcrme yetene\u011fini bozabilir.<\/p>\n<p><strong>1.2. Laboratuvar Ko\u015fullar\u0131<\/strong><\/p>\n<p>Embriyoloji laboratuvar\u0131ndaki suboptimal k\u00fclt\u00fcr ko\u015fullar\u0131, ortam bile\u015fimi veya s\u0131cakl\u0131k dalgalanmalar\u0131 embriyo geli\u015fimini etkileyebilir (Swain, 2019). K\u00fc\u00e7\u00fck prosed\u00fcrel tutars\u0131zl\u0131klar bile implantasyon potansiyelini tehlikeye atabilir. Yine de g\u00fcn\u00fcm\u00fcz teknolojisiyle, \u00e7o\u011fu IVF laboratuvar\u0131nda laboratuvar ko\u015fullar\u0131 iyi bir \u015fekilde izlenir ve kontrol edilir.<\/p>\n<h4><strong>2. <span style=\"text-decoration: underline;\">Rahim Fakt\u00f6rleri<\/span><\/strong><\/h4>\n<p><strong><br>2.1. Yap\u0131sal Anormallikler<\/strong><\/p>\n<p>Miyomlar, polipler, yap\u0131\u015f\u0131kl\u0131klar ve konjenital malformasyonlar gibi rahim anomalileri embriyonun tutunmas\u0131n\u0131 engelleyebilir (Pundir &amp; El-Toukhy, 2010). Histeroskopi veya di\u011fer g\u00f6r\u00fcnt\u00fcleme y\u00f6ntemleri genellikle bu durumlar\u0131 te\u015fhis etmek ve muhtemelen tedavi etmek i\u00e7in kullan\u0131l\u0131r.<\/p>\n<p><strong>2.2. Endometriyal Al\u0131c\u0131l\u0131k<\/strong><\/p>\n<p>\u0130mplantasyon penceresi (WOI), endometriyumun en iyi \u015fekilde al\u0131c\u0131 oldu\u011fu s\u0131n\u0131rl\u0131 bir d\u00f6nemi temsil eder. WOI zamanlamas\u0131ndaki de\u011fi\u015fiklikler veya kronik endometrit, implantasyonu bozabilir ve ki\u015fiselle\u015ftirilmi\u015f yakla\u015f\u0131mlar\u0131 gerekli k\u0131labilir (D\u00edaz-Gimeno ve ark., 2013). En son yakla\u015f\u0131mlar aras\u0131nda, endometriyal kal\u0131nl\u0131k veya g\u00f6r\u00fcn\u00fcm endi\u015fe verici hale geldi\u011finde embriyo transferinden yakla\u015f\u0131k 2-3 g\u00fcn \u00f6nce endometriyuma Gran\u00fclosit-koloni uyar\u0131c\u0131 fakt\u00f6r (G-CSF) veya trombositten zengin plazma (PRP) enjeksiyonu yer al\u0131r.<\/p>\n<p><strong>2.3. \u0130mm\u00fcnolojik D\u00fczensizlik<\/strong><\/p>\n<p>Uterin do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc (uNK) h\u00fccrelerinin dengesizli\u011fi de dahil olmak \u00fczere anormal uterin ba\u011f\u0131\u015f\u0131kl\u0131k tepkileri, tekrarlayan IVF ba\u015far\u0131s\u0131zl\u0131klar\u0131nda rol oynamaktad\u0131r (Kwak-Kim ve ark., 2012). Ancak, kan testlerinde bulunan NK pop\u00fclasyonlar\u0131, \u00fcreme kanal\u0131nda bulunan NK pop\u00fclasyonlar\u0131yla mutlaka ili\u015fkili olmayabilir. Bu nedenle, bazen bu testler tan\u0131 veya tedavi ama\u00e7l\u0131 olarak yararl\u0131 olmayabilir. Geli\u015fmi\u015f ba\u011f\u0131\u015f\u0131kl\u0131k testleri olduk\u00e7a maliyetli olabilir. Baz\u0131 durumlarda, bu t\u00fcr invaziv ve maliyet a\u00e7\u0131s\u0131ndan engelleyici testler olmadan profilaktik \u00f6nlemler al\u0131nabilir.<\/p>\n<h4><span style=\"text-decoration: underline;\"><strong>3. Sistemik ve Hormonal Fakt\u00f6rler<\/strong><\/span><\/h4>\n<p><strong><br>3.1. Anne Ya\u015f\u0131 ve Yumurtal\u0131k Rezervi<\/strong><\/p>\n<p>\u0130leri anne ya\u015f\u0131, azalm\u0131\u015f yumurtal\u0131k rezervi, daha d\u00fc\u015f\u00fck oosit kalitesi ve artm\u0131\u015f embriyo aneuploidisi oranlar\u0131yla ili\u015fkilidir (Broekmans ve ark., 2009). Anti-M\u00fcllerian hormonu (AMH) ve antral folik\u00fcl say\u0131m\u0131 (AFC) gibi testler yumurtal\u0131k rezervini de\u011ferlendirmeye yard\u0131mc\u0131 olur.<\/p>\n<p>K\u00f6t\u00fc yumurta kalitesi, ileri anne ya\u015f\u0131 ve sa\u011fl\u0131ks\u0131z ya\u015fam tarz\u0131 se\u00e7imleri gibi fakt\u00f6rler embriyo kalitesini etkileyebilir. Beslenme, takviyeler (\u00f6rn. CoQ10, fisetin, Omega-3, NMN, vb.) ve ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri yoluyla bunlara de\u011finmek yard\u0131mc\u0131 olabilir. L\u00fctfen \u201c<a href=\"https:\/\/www.lowcostivf.net\/tr\/latest-news-from-north-cyprus-ivf-center\/oocyte-anti-aging-protocol\/\">oosit ya\u015flanma kar\u015f\u0131t\u0131 protokol\u00fc<\/a>Daha fazla bilgi i\u00e7in.<\/p>\n<p>Daha ileri ya\u015f gruplar\u0131ndaki hastalar\u0131n, a\u015fa\u011f\u0131dakiler gibi baz\u0131 alternatif se\u00e7enekleri g\u00f6z \u00f6n\u00fcnde bulundurmas\u0131 gerekebilir: <a href=\"https:\/\/www.lowcostivf.net\/tr\/prp-treatment\/\">yumurtal\u0131k PRP<\/a>, <a href=\"https:\/\/www.lowcostivf.net\/tr\/mitochondrial-replacement-therapy\/\">Mitokondriyal replasman tedavisi<\/a> ve muhtemelen <a href=\"https:\/\/www.lowcostivf.net\/tr\/ivf-with-donor-eggs1\/\">Don\u00f6r yumurtalar\u0131 kullan\u0131larak t\u00fcp bebek tedavisi<\/a>.<\/p>\n<p><strong>3.2. Endokrin Bozukluklar\u0131<\/strong><\/p>\n<p>Tiroid disfonksiyonu, polikistik over sendromu (PCOS) ve hiperprolaktinemi gibi durumlar ba\u015far\u0131l\u0131 implantasyon i\u00e7in gereken hormonal ortam\u0131 bozabilir (Palomba ve di\u011ferleri, 2015). IVF&#039;ye ba\u015flamadan \u00f6nce bu ko\u015fullar\u0131n optimize edilmesi esast\u0131r. Bu nedenle herhangi bir IVF tedavisinden \u00f6nce FSH, LH, AMH, Prolaktin, TSH ve fT4&#039;\u00fc i\u00e7eren bir endokrin de\u011ferlendirmesi yap\u0131lmal\u0131d\u0131r.<\/p>\n<p><strong>3.3. Trombofili ve P\u0131ht\u0131la\u015fma Sorunlar\u0131<\/strong><\/p>\n<p>Antifosfolipid sendromu gibi kal\u0131tsal veya edinilmi\u015f trombofilik durumlar, plasenta geli\u015fiminin bozulmas\u0131na ve tekrarlayan implantasyon ba\u015far\u0131s\u0131zl\u0131\u011f\u0131na yol a\u00e7abilir (Rai &amp; Regan, 2006). IVF uzman\u0131 taraf\u0131ndan kapsaml\u0131 bir de\u011ferlendirmeden sonra se\u00e7ilmi\u015f vakalarda antikoag\u00fclan tedavi faydal\u0131 olabilir.<\/p>\n<h4><u><strong>4. Erkek Fakt\u00f6r\u00fc Katk\u0131lar\u0131<\/strong><\/u><\/h4>\n<p><strong>4.1. Sperm Kalitesi<\/strong><\/p>\n<p>D\u00fc\u015f\u00fck sperm kalitesi, \u00f6zellikle y\u00fcksek d\u00fczeyde DNA par\u00e7alanmas\u0131, d\u00fc\u015f\u00fck d\u00f6llenme ve embriyo geli\u015fimi sonu\u00e7lar\u0131na katk\u0131da bulunabilir (Simon ve di\u011ferleri, 2017). Sperm sa\u011fl\u0131\u011f\u0131 ve spermle ilgili sorunlar hakk\u0131nda daha fazla bilgi &quot;<a href=\"https:\/\/www.lowcostivf.net\/tr\/latest-news-from-north-cyprus-ivf-center\/the-effects-of-aging-on-sperm-cells-sperm-anti-aging-protocol\/\">Sperm Ya\u015flanma Kar\u015f\u0131t\u0131 Protokoller<\/a>\u201d sayfas\u0131. Sperm DNA par\u00e7alanmas\u0131n\u0131n sorun oldu\u011fu durumlarda, \u201c gibi geli\u015fmi\u015f sperm se\u00e7me y\u00f6ntemleri<a href=\"https:\/\/www.lowcostivf.net\/tr\/advanced-sperm-selection\/\">manyetik aktive edilmi\u015f h\u00fccre ay\u0131rma<\/a>Genetik olarak anormal sperm h\u00fccrelerinin se\u00e7ilme olas\u0131l\u0131\u011f\u0131n\u0131 azaltmak amac\u0131yla kullan\u0131labilir.<\/p>\n<p><strong>4.2. Epigenetik ve Kromozomal Anormallikler<\/strong><\/p>\n<p>Ortaya \u00e7\u0131kan kan\u0131tlar, sperm epigenetik de\u011fi\u015fikliklerinin ve kromozomal anomalilerin tekrarlayan IVF ba\u015far\u0131s\u0131zl\u0131klar\u0131nda da rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir (Zini ve ark., 2011). Embriyolar\u0131n kromozomal anomaliler a\u00e7\u0131s\u0131ndan taranmas\u0131, embriyo transferi i\u00e7in uygulanabilir embriyolar\u0131n se\u00e7imini iyile\u015ftirebilir ve kromozomal sorunlar\u0131 olabilecek embriyolar\u0131n transfer edilme olas\u0131l\u0131\u011f\u0131n\u0131 azaltabilir. Daha fazla bilgi i\u00e7in &quot;<a href=\"https:\/\/www.lowcostivf.net\/tr\/pre-implantation-genetic-diagnosis-pgd\/\">\u0130mplantasyon \u00d6ncesi Genetik Test<\/a>&quot; sayfa.<\/p>\n<h4><span style=\"text-decoration: underline;\"><strong>5. D\u0131\u015f ve Ya\u015fam Tarz\u0131 Fakt\u00f6rleri<\/strong><\/span><\/h4>\n<p><strong><br>5.1. \u00c7evresel Maruziyetler<\/strong><\/p>\n<p>Endokrin bozucu kimyasallar (EDC&#039;ler) gibi toksinlere maruz kalmak, gamet kalitesini ve implantasyon oranlar\u0131n\u0131 olumsuz y\u00f6nde etkileyebilir (Hannon &amp; Flaws, 2015).<\/p>\n<p><strong>5.2. Ya\u015fam Tarz\u0131 Fakt\u00f6rleri<\/strong><\/p>\n<p>Obezite, sigara ve a\u015f\u0131r\u0131 alkol t\u00fcketimi, do\u011furganl\u0131\u011f\u0131n ve IVF ba\u015far\u0131 oranlar\u0131n\u0131n azalmas\u0131yla ba\u011flant\u0131l\u0131d\u0131r. Ya\u015fam tarz\u0131 m\u00fcdahaleleri sonu\u00e7lar\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirebilir (Bellver ve di\u011ferleri, 2013).<\/p>\n<p><strong>5.3. Psikolojik Stres<\/strong><\/p>\n<p>K\u0131s\u0131rl\u0131\u011f\u0131n ve t\u00fcp bebek tedavisinin psikolojik y\u00fck\u00fc, n\u00f6roendokrin yollar arac\u0131l\u0131\u011f\u0131yla sonu\u00e7lar\u0131 olumsuz etkileyebilir; ancak bulgular hen\u00fcz kesinlik kazanmam\u0131\u015ft\u0131r (Matthiesen ve ark., 2011).<\/p>\n<p>Tekrarlayan IVF ba\u015far\u0131s\u0131zl\u0131klar\u0131 genellikle birden fazla fakt\u00f6r\u00fcn birle\u015fiminden kaynaklan\u0131r ve tan\u0131 ve tedavi i\u00e7in multidisipliner bir yakla\u015f\u0131m gerektirir. Tan\u0131 testlerindeki yenilikler, ki\u015fiselle\u015ftirilmi\u015f t\u0131p ve ART teknikleri sonu\u00e7lar\u0131 iyile\u015ftirmek i\u00e7in umut vadediyor. Klinisyenler ayr\u0131ca hastalar\u0131n duygusal refah\u0131n\u0131 da g\u00f6z \u00f6n\u00fcnde bulundurmal\u0131 ve hem t\u0131bbi hem de psikososyal sonu\u00e7lar\u0131 optimize etmek i\u00e7in kapsaml\u0131 bak\u0131m sunmal\u0131d\u0131r.<\/p>\n<p>Protokolleri bireysel hastaya g\u00f6re uyarlamak daha kaliteli yumurta ve embriyolarla sonu\u00e7lanabilir. Bunun i\u00e7in IVF ekibimiz \u00f6nceki IVF protokollerinize dikkatlice bakacak ve bize daha iyi sonu\u00e7lar sa\u011flamas\u0131 muhtemel bir protokol tasarlayacakt\u0131r. Baz\u0131 durumlarda, bir kad\u0131n\u0131n yumurtal\u0131k aktivitesi \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131nda, elde edilen embriyo say\u0131s\u0131n\u0131 en \u00fcst d\u00fczeye \u00e7\u0131karmak i\u00e7in birden fazla yumurta al\u0131m\u0131 planlanabilir ve b\u00f6ylece embriyo transferi i\u00e7in uygulanabilir embriyolar elde etme \u015fans\u0131 art\u0131r\u0131labilir.<\/p>\n<p><strong><br>Referanslar:<\/strong><\/p>\n<p>Alfarawati, S., Fragouli, E., Colls, P., ve di\u011ferleri (2011). Blastosist morfolojisi, kromozomal anormallik ve embriyo cinsiyeti aras\u0131ndaki ili\u015fki. <em>Do\u011furganl\u0131k ve K\u0131s\u0131rl\u0131k, 95<\/em>(2), 520\u2013524.<\/p>\n<p>Bellver, J., Rossal, LP, Bosch, E., ve di\u011ferleri (2013). Obezite ve IVF veya ICSI sonras\u0131 d\u00fc\u015f\u00fck riski. <em>\u0130nsan \u00dcreme G\u00fcncellemesi, 19<\/em>(3), 252\u2013265.<\/p>\n<p>Broekmans, FJ, Knauff, EA, Valkenburg, O., ve di\u011ferleri (2009). Kad\u0131n \u00fcreme sisteminin ya\u015flanmas\u0131: G\u00fcncel bilgiler ve gelecekteki e\u011filimler. <em>Endokrinoloji ve Metabolizma Trendleri, 18<\/em>(2), 58\u201365.<\/p>\n<p>D\u00edaz-Gimeno, P., Ruiz-Alonso, M., Blesa, D., ve di\u011ferleri (2013). Endometriyal al\u0131c\u0131l\u0131k dizisinin do\u011frulu\u011fu ve tekrarlanabilirli\u011fi, endometriyal al\u0131c\u0131l\u0131k i\u00e7in bir tan\u0131 y\u00f6ntemi olarak histolojiden \u00fcst\u00fcnd\u00fcr. <em>Do\u011furganl\u0131k ve K\u0131s\u0131rl\u0131k, 99<\/em>(2), 508\u2013517.<\/p>\n<p>Fragouli, E. ve Wells, D. (2012). Embriyo se\u00e7imi i\u00e7in aneuploidi taramas\u0131. <em>\u00dcreme T\u0131bb\u0131 Seminerleri, 30<\/em>(4), 289\u2013302.<\/p>\n<p>Hannon, PR ve Flaws, JA (2015). Ftalatlar\u0131n yumurtal\u0131k \u00fczerindeki etkileri. <em>Endokrinolojide S\u0131n\u0131rlar, 6<\/em>, 8.<\/p>\n<p>Kwak-Kim, J., Yang, KM ve Gilman-Sachs, A. (2012). Tekrarlayan gebelik kayb\u0131 ve tekrarlayan implantasyon ba\u015far\u0131s\u0131zl\u0131\u011f\u0131: Ba\u011f\u0131\u015f\u0131kl\u0131k mekanizmalar\u0131. <em>Klinik Kad\u0131n Hastal\u0131klar\u0131 ve Do\u011fum, 55<\/em>(3), 914\u2013927.<\/p>\n<p>Matthiesen, SM, Frederiksen, Y., Ingerslev, HJ, ve di\u011ferleri. (2011). Yard\u0131mla \u00fcreme teknolojisinin (ART) stresi, s\u0131k\u0131nt\u0131s\u0131 ve sonu\u00e7lar\u0131: Bir meta-analiz. <em>\u0130nsan \u00dcremesi, 26<\/em>(10), 2763\u20132776.<\/p>\n<p>Palomba, S., Santagni, S., Falbo, A., ve di\u011ferleri (2015). Polikistik over sendromuyla ili\u015fkili komplikasyonlar ve zorluklar: G\u00fcncel perspektifler. <em>Uluslararas\u0131 Kad\u0131n Sa\u011fl\u0131\u011f\u0131 Dergisi, 7<\/em>, 745\u2013763.<\/p>\n<p>Pundir, J. ve El-Toukhy, T. (2010). Tekrarlayan implantasyon ba\u015far\u0131s\u0131zl\u0131\u011f\u0131nda uterus fakt\u00f6rleri. <em>Kad\u0131n Hastal\u0131klar\u0131 ve Do\u011fumda G\u00fcncel G\u00f6r\u00fc\u015f, 22<\/em>(3), 229\u2013234.<\/p>\n<p>Rai, R. ve Regan, L. (2006). Tekrarlayan d\u00fc\u015f\u00fckler. <em>Lancet, 368<\/em>(9535), 601\u2013611.<\/p>\n<p>Simon, L., Brunborg, G., Stevenson, M., ve di\u011ferleri (2017). Yard\u0131mc\u0131 \u00fcreme tekniklerinde sperm DNA hasar\u0131n\u0131n klinik etkileri. <em>\u0130nsan \u00dcremesi, 32<\/em>(7), 1309\u20131317.<\/p>\n<p>Swain, JE (2019). IVF laboratuvar\u0131nda k\u00fclt\u00fcr ortam\u0131n\u0131n optimize edilmesi: pH ve s\u0131cakl\u0131\u011f\u0131n gamet ve embriyo kalitesine etkisi. <em>\u00dcreme Biyomedikal \u00c7evrimi\u00e7i, 38<\/em>(3), 283\u2013291.<\/p>\n<p>Zegers-Hochschild, F., Adamson, GD, de Mouzon, J., ve di\u011ferleri (2017). K\u0131s\u0131rl\u0131k ve do\u011furganl\u0131k bak\u0131m\u0131na ili\u015fkin uluslararas\u0131 s\u00f6zl\u00fck. <em>Do\u011furganl\u0131k ve K\u0131s\u0131rl\u0131k, 108<\/em>(3), 393\u2013406.<\/p>\n<p>Zini, A., Bielecki, R., Phang, D., ve di\u011ferleri (2011). Sperm DNA b\u00fct\u00fcnl\u00fc\u011f\u00fc testi: Klinik y\u00f6nler ve \u00e7\u0131kar\u0131mlar. <em>Androloji Dergisi, 32<\/em>(2), 151\u2013165.<\/p>\n<p><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-44d475d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"44d475d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-84f69f4\" data-id=\"84f69f4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4d6d020 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4d6d020\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-80d8980\" data-id=\"80d8980\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b46694 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"2b46694\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/female-infertility\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/female-infertility-350x250.jpg);\" role=\"img\" aria-label=\"kad\u0131n k\u0131s\u0131rl\u0131\u011f\u0131\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tKad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Kad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131n\u0131n Nedenleri ve Tedavisi<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Kad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-adced36\" data-id=\"adced36\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-242904b elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"242904b\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/male-infertility\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Male-Infertility-350x250.jpg);\" role=\"img\" aria-label=\"Erkek K\u0131s\u0131rl\u0131\u011f\u0131\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tErkek K\u0131s\u0131rl\u0131\u011f\u0131\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Erkek K\u0131s\u0131rl\u0131\u011f\u0131n\u0131n Nedenleri ve Tedavisi<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Erkek K\u0131s\u0131rl\u0131\u011f\u0131<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-0701b21\" data-id=\"0701b21\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45ae454 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"45ae454\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/testing\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Testing-350x250.jpg);\" role=\"img\" aria-label=\"Test yapmak\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tTest yapmak\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">K\u0131s\u0131rl\u0131k Testi ve Te\u015fhisi<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Test yapmak<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d2990ef elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d2990ef\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-a139f8b\" data-id=\"a139f8b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-52abe74 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"52abe74\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/treatment-decision\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Treatment-Decision-350x250.jpg);\" role=\"img\" aria-label=\"Tedavi-Karar\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tTedavi Karar\u0131\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Do\u011fru Tedaviyi Se\u00e7mek<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Tedavi Karar\u0131<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-d4f19d6\" data-id=\"d4f19d6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d819606 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"d819606\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/miscarriages\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Miscarriages-350x250.jpg);\" role=\"img\" aria-label=\"D\u00fc\u015f\u00fckler\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tD\u00fc\u015f\u00fckler\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Tekrarlayan D\u00fc\u015f\u00fckler ve Tedavi Se\u00e7enekleri<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">D\u00fc\u015f\u00fckler<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-54eb32e\" data-id=\"54eb32e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-512b12c elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"512b12c\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/improving-fertility\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/improving-fertility-350x250.jpg);\" role=\"img\" aria-label=\"do\u011furganl\u0131\u011f\u0131n iyile\u015ftirilmesi\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tDo\u011furganl\u0131\u011f\u0131 Art\u0131rmak\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Do\u011furganl\u0131k seviyenizi nas\u0131l iyile\u015ftirirsiniz (Y\u00fckseltirsiniz)?<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Do\u011furganl\u0131k<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>T\u00fcp Bebek D\u00f6ng\u00fcs\u00fcn\u00fcn Ba\u015far\u0131s\u0131z Olmas\u0131n\u0131n Nedenleri Nelerdir? \u0130lgili Konular Kad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131 Nedenleri ve Y\u00f6netimi Erkek K\u0131s\u0131rl\u0131\u011f\u0131 Nedenleri ve Y\u00f6netimi K\u0131s\u0131rl\u0131k Testi ve Tan\u0131s\u0131 Tekrarlayan T\u00fcp Bebek Ba\u015far\u0131s\u0131zl\u0131klar\u0131 Tekrarlayan D\u00fc\u015f\u00fckler T\u00fcp bebek, yard\u0131mc\u0131 \u00fcreme teknolojilerinin (ART) temel ta\u015f\u0131 haline gelmi\u015f olup, k\u0131s\u0131rl\u0131kla kar\u015f\u0131 kar\u015f\u0131ya kalan \u00e7iftlere umut sunmaktad\u0131r. Ancak, birden fazla t\u00fcp bebek d\u00f6ng\u00fcs\u00fcnden sonra klinik gebelik elde edilememesi [\u2026]<\/p>","protected":false},"author":1,"featured_media":1526,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-702","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>IVF Failures - North Cyprus IVF<\/title>\n<meta name=\"description\" content=\"The reason behind IVF failures are often the eggs and the sperm. 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