{"id":19250,"date":"2025-08-17T16:10:20","date_gmt":"2025-08-17T16:10:20","guid":{"rendered":"https:\/\/www.lowcostivf.net\/?p=19250"},"modified":"2025-08-17T16:11:22","modified_gmt":"2025-08-17T16:11:22","slug":"low-amh-level-is-it-still-possible-to-use-my-own-eggs-in-an-ivf-cycle","status":"publish","type":"post","link":"https:\/\/www.lowcostivf.net\/fr\/latest-news-from-north-cyprus-ivf-center\/low-amh-level-is-it-still-possible-to-use-my-own-eggs-in-an-ivf-cycle\/","title":{"rendered":"Faible taux d\u2019AMH : est-il encore possible d\u2019utiliser mes propres ovules dans un cycle de FIV ?"},"content":{"rendered":"

\n L'hormone antim\u00fcll\u00e9rienne (AMH) est produite par les petits follicules des ovaires f\u00e9minins et constitue l'un des marqueurs les plus fiables de la r\u00e9serve ovarienne, qui repr\u00e9sente le nombre d'ovules restant dans les ovaires. Contrairement aux autres hormones de la reproduction, l'AMH est s\u00e9cr\u00e9t\u00e9e localement par les cellules de la granulosa des follicules pr\u00e9antraux et antraux. Sa production ne d\u00e9pend ni du cerveau ni des boucles de r\u00e9troaction hormonales qui r\u00e9gissent le cycle menstruel. De ce fait, l'AMH refl\u00e8te directement le nombre de follicules en d\u00e9veloppement \u00e0 un instant T et reste relativement stable tout au long du cycle, ind\u00e9pendamment du jour du test ou des fluctuations hormonales temporaires.\n<\/p>\n\n\n\n

\n Cela contraste avec d'autres hormones de fertilit\u00e9 telles que la FSH, la LH et l'\u0153stradiol, qui font partie de l'axe hypothalamo-hypophyso-ovarien (HPO). Ces hormones sont influenc\u00e9es par un syst\u00e8me complexe de r\u00e9troaction. Par exemple, lorsque l'activit\u00e9 ovarienne diminue et que moins de follicules produisent des \u0153strog\u00e8nes et de l'inhibine B, les taux de FSH augmentent pour compenser. Cependant, les taux de FSH et d'\u0153stradiol peuvent varier consid\u00e9rablement selon la phase du cycle, le stress, voire la prise de m\u00e9dicaments \u00e0 court terme, et peuvent parfois para\u00eetre normaux malgr\u00e9 une r\u00e9serve ovarienne r\u00e9duite.\n<\/p>\n\n\n\n

\n L'AMH refl\u00e9tant directement l'activit\u00e9 ovarienne plut\u00f4t que par des m\u00e9canismes de r\u00e9troaction, elle offre une mesure plus claire et plus objective de la r\u00e9serve ovarienne. Des valeurs d'AMH \u00e9lev\u00e9es sugg\u00e8rent g\u00e9n\u00e9ralement une cohorte de follicules plus importante et une r\u00e9ponse plus forte \u00e0 la stimulation ovarienne. \u00c0 l'inverse, une AMH tr\u00e8s faible, voire ind\u00e9tectable, indique une r\u00e9serve ovarienne diminu\u00e9e. Il est n\u00e9anmoins important de rappeler que l'AMH refl\u00e8te la quantit\u00e9<\/em> des \u0153ufs, pas leurs qualit\u00e9<\/em>. Il ne permet pas de pr\u00e9dire avec certitude une conception naturelle, mais il joue un r\u00f4le central dans la planification des traitements de fertilit\u00e9. Il permet de d\u00e9terminer si une femme est susceptible de r\u00e9pondre \u00e0 une stimulation avec ses propres ovules en FIV, si des th\u00e9rapies de rajeunissement ovarien comme le PRP sont envisageables, ou si le don d'ovules constitue l'option la plus r\u00e9aliste.\n<\/p>\n\n\n\n

\n Si l'\u00e2ge reste le facteur le plus important pour la fertilit\u00e9, les progr\u00e8s de la m\u00e9decine reproductive ouvrent de nouvelles perspectives aux femmes qui souhaitent pr\u00e9server ou restaurer leur capacit\u00e9 reproductive. Au Centre de FIV de Chypre du Nord, le Dr Savas Ozyigit a mis au point des strat\u00e9gies de rajeunissement ovarien visant \u00e0 am\u00e9liorer la fonction ovarienne et les r\u00e9sultats de la FIV, offrant ainsi un nouvel espoir aux femmes qui disposaient auparavant de tr\u00e8s peu d'options.\n<\/p>\n\n\n\n

\n Voici comment des strat\u00e9gies innovantes contribuent \u00e0 red\u00e9finir ce qui est possible.\n<\/p>\n\n\n\n

1. Traitement PRP ovarien<\/a>: R\u00e9veil des \u0153ufs dormants<\/strong><\/p>\n\n\n\n

\n Le traitement par plasma riche en plaquettes ovariennes (PRP) est une technique \u00e9mergente en m\u00e9decine de la reproduction. Il consiste \u00e0 injecter directement dans les ovaires le plasma de la patiente, enrichi en facteurs de croissance. L'objectif est de stimuler les follicules primordiaux dormants et, potentiellement, de relancer le d\u00e9veloppement de l'ovule. La justification biologique repose sur le potentiel r\u00e9g\u00e9n\u00e9rateur des plaquettes, qui lib\u00e8rent diverses cytokines et facteurs de croissance connus pour favoriser la r\u00e9paration tissulaire, l'angiogen\u00e8se et la prolif\u00e9ration cellulaire (Sills et Wood, 2019\u00a0; Pantos et al., 2019).\n<\/p>\n\n\n\n

\n Dans certains protocoles, le PRP est associ\u00e9 \u00e0 des exosomes, de petites v\u00e9sicules extracellulaires d\u00e9riv\u00e9es de cellules souches jouant un r\u00f4le dans la communication intercellulaire. Les exosomes transportent des prot\u00e9ines, des lipides et des acides nucl\u00e9iques susceptibles d'am\u00e9liorer le microenvironnement ovarien, de r\u00e9duire le stress oxydatif et d'am\u00e9liorer les conditions de la folliculogen\u00e8se (Mojadadi et al., 2021). Cette approche combin\u00e9e vise non seulement \u00e0 r\u00e9veiller les follicules dormants, mais aussi \u00e0 cr\u00e9er une niche plus favorable \u00e0 la maturation des ovocytes.\n<\/p>\n\n\n\n

\n Cependant, le succ\u00e8s potentiel du traitement par PRP ovarien d\u00e9pend de la pr\u00e9sence ou non de follicules r\u00e9siduels. Un taux d'hormone antim\u00fcll\u00e9rienne (AMH) d\u00e9tectable est g\u00e9n\u00e9ralement consid\u00e9r\u00e9 comme essentiel, car une AMH ind\u00e9tectable refl\u00e8te g\u00e9n\u00e9ralement l'absence de follicules viables et donc un manque de substrat biologique sur lequel le PRP peut agir (Polyzos et Devroey, 2011). Chez les femmes pr\u00e9sentant une activit\u00e9 ovarienne faible mais mesurable, le PRP peut contribuer \u00e0 am\u00e9liorer le recrutement folliculaire naturel et les chances de pr\u00e9l\u00e8vement d'ovules lors des cycles de FIV ult\u00e9rieurs. En revanche, chez les femmes pr\u00e9sentant un taux d'AMH ind\u00e9tectable et l'absence de follicules antraux visibles, le PRP ovarien est peu susceptible d'apporter un b\u00e9n\u00e9fice.\n<\/p>\n\n\n\n

2. Banque d'ovules<\/a><\/strong><\/p>\n\n\n\n

\n La conservation d'ovules n'est pas une id\u00e9e nouvelle en procr\u00e9ation m\u00e9dicalement assist\u00e9e, mais elle est souvent n\u00e9glig\u00e9e en tant que moyen tr\u00e8s efficace d'am\u00e9liorer les r\u00e9sultats de la FIV. Lorsqu'une femme subit une stimulation ovarienne contr\u00f4l\u00e9e, le nombre d'ovules matures pr\u00e9lev\u00e9s peut \u00eatre limit\u00e9, en particulier chez les femmes de plus de 35 ans ou celles dont la r\u00e9serve ovarienne est r\u00e9duite. Avec un nombre r\u00e9duit d'ovules, les chances de d\u00e9velopper un blastocyste sain sont faibles. Cela s'explique non seulement par la quantit\u00e9, mais aussi par la baisse de la qualit\u00e9 des ovules avec l'\u00e2ge. Des probl\u00e8mes tels que les anomalies du fuseau mitochondrial, les dysfonctionnements mitochondriaux et les taux plus \u00e9lev\u00e9s d'anomalies chromosomiques deviennent de plus en plus fr\u00e9quents avec l'\u00e2ge (Franasiak et al., 2014\u00a0; Fragouli et Wells, 2012).\n<\/p>\n\n\n\n

\n La conservation d'ovules r\u00e9sout ce probl\u00e8me en permettant aux patientes de subir plusieurs stimulations et pr\u00e9l\u00e8vements d'ovules avant de tenter une f\u00e9condation et un transfert. En regroupant les ovules de plusieurs cycles, le nombre total d'ovules disponibles pour la f\u00e9condation est augment\u00e9, ce qui augmente les chances de cr\u00e9er un ou plusieurs embryons sains. Cette approche est particuli\u00e8rement utile pour les femmes dans la quarantaine, chez qui un plus grand nombre d'ovules peut \u00eatre n\u00e9cessaire pour obtenir au moins un embryon chromosomiquement normal (Goldman et al., 2017). Des \u00e9tudes cliniques ont montr\u00e9 que les taux cumul\u00e9s de naissances vivantes sont significativement plus \u00e9lev\u00e9s lorsque plusieurs cycles sont r\u00e9alis\u00e9s et que les ovules sont conserv\u00e9s, plut\u00f4t que de se fier uniquement aux r\u00e9sultats d'un seul cycle (Smith et al., 2015\u00a0; Drakopoulos et al., 2016).\n<\/p>\n\n\n\n

\n En pratique, cette strat\u00e9gie peut faire la diff\u00e9rence entre des d\u00e9ceptions r\u00e9p\u00e9t\u00e9es et une grossesse r\u00e9ussie. En acceptant qu'un seul cycle puisse ne pas suffire et en investissant dans plusieurs cycles de stimulation, les patientes se donnent les meilleures chances de produire des embryons aptes au transfert. La conservation d'ovules n'est donc pas une simple option technique, mais peut \u00eatre une \u00e9tape cruciale pour maximiser le potentiel reproductif et aider les couples \u00e0 atteindre leur objectif d'enfant.\n<\/p>\n\n\n\n

3. Th\u00e9rapie de remplacement mitochondrial<\/a>: Revitaliser la qualit\u00e9 des \u0153ufs<\/strong><\/p>\n\n\n\n

\n Pour de nombreuses femmes en \u00e2ge de procr\u00e9er avanc\u00e9, le principal d\u00e9fi n'est pas le nombre d'ovules disponibles, mais leur qualit\u00e9. Les embryons peuvent ne pas se d\u00e9velopper normalement ou \u00eatre porteurs d'anomalies chromosomiques (aneuplo\u00efdie), \u00e9troitement li\u00e9es au dysfonctionnement mitochondrial li\u00e9 \u00e0 l'\u00e2ge. Les mitochondries sont les organites producteurs d'\u00e9nergie au sein de la cellule, et leur d\u00e9clin avec l'\u00e2ge peut alt\u00e9rer la capacit\u00e9 des ovules \u00e0 assurer une f\u00e9condation et un d\u00e9veloppement embryonnaire normaux (Wilding et al., 2009\u00a0; Fragouli et al., 2011).\n<\/p>\n\n\n\n

\n La th\u00e9rapie de remplacement mitochondrial (TRM) vise \u00e0 r\u00e9soudre ce probl\u00e8me en introduisant des mitochondries saines provenant d'un ovocyte de donneuse dans l'ovule de la patiente, tout en pr\u00e9servant son ADN nucl\u00e9aire. Cette approche r\u00e9g\u00e9n\u00e8re efficacement l'approvisionnement \u00e9nerg\u00e9tique de l'ovule et peut restaurer sa capacit\u00e9 de d\u00e9veloppement. Des recherches pionni\u00e8res men\u00e9es par le Dr Shoukhrat Mitalipov et ses coll\u00e8gues ont d\u00e9montr\u00e9 que le transfert de mat\u00e9riel g\u00e9n\u00e9tique nucl\u00e9aire dans le cytoplasme du donneur contenant des mitochondries saines peut conduire \u00e0 une f\u00e9condation et un d\u00e9veloppement embryonnaire normaux, et a \u00e9galement le potentiel de r\u00e9duire la transmission des maladies mitochondriales (Tachibana et al., 2009\u00a0; Tachibana et al., 2013\u00a0; Kang et al., 2016).\n<\/p>\n\n\n\n

\n Au Centre de FIV de Chypre du Nord, cette technologie de pointe est appliqu\u00e9e \u00e0 des cas soigneusement s\u00e9lectionn\u00e9s de femmes produisant des ovules mais connaissant des \u00e9checs r\u00e9p\u00e9t\u00e9s de FIV en raison d'un mauvais d\u00e9veloppement embryonnaire ou d'aneuplo\u00efdies r\u00e9currentes. En restaurant la fonction mitochondriale, la TRM offre aux patientes une nouvelle opportunit\u00e9 d'obtenir des embryons viables et d'am\u00e9liorer leurs chances de grossesse.\n<\/p>\n\n\n\n

4. FIV en tandem<\/a>:Un plan de sauvegarde personnalis\u00e9<\/strong><\/p>\n\n\n\n

\n Un cycle de FIV en tandem permet d'utiliser les propres ovules de la patiente et ceux d'une donneuse au cours du m\u00eame cycle de traitement. L'objectif n'est pas de remplacer le potentiel reproductif de la patiente, mais de le pr\u00e9server. En combinant les deux sources d'ovocytes, le traitement offre un filet de s\u00e9curit\u00e9 int\u00e9gr\u00e9\u00a0: si les propres ovules de la patiente ne parviennent pas \u00e0 f\u00e9conder ou \u00e0 se d\u00e9velopper en embryons viables, les ovules d'une donneuse sont d\u00e9j\u00e0 disponibles au cours du m\u00eame cycle.\n<\/p>\n\n\n\n

\n Cette approche peut s'av\u00e9rer particuli\u00e8rement rentable et rassurante sur le plan \u00e9motionnel, car elle \u00e9vite de recourir \u00e0 plusieurs cycles de FIV si les ovocytes de la patiente ne produisent pas d'embryons aptes au transfert. Au lieu de subir la d\u00e9ception d'un transfert annul\u00e9 ou du report d'un nouveau cycle, les patientes ont la possibilit\u00e9 de recourir imm\u00e9diatement \u00e0 des embryons issus d'une donneuse. De plus, les embryons non transf\u00e9r\u00e9s peuvent \u00eatre cryoconserv\u00e9s pour une utilisation ult\u00e9rieure, que ce soit comme solution de secours en cas d'\u00e9chec du cycle en cours ou pour fonder une famille ult\u00e9rieurement.\n<\/p>\n\n\n\n

\n Les cycles en tandem sont particuli\u00e8rement adapt\u00e9s aux femmes pr\u00e9sentant une r\u00e9serve ovarienne diminu\u00e9e ou une qualit\u00e9 d'ovocytes limit\u00e9e, qui souhaitent n\u00e9anmoins tenter un traitement avec leurs propres ovocytes, sans risquer un cycle vide. Si les femmes en \u00e2ge de procr\u00e9er avanc\u00e9 ou les r\u00e9pondeuses peu r\u00e9actives pr\u00e9sentent souvent de faibles taux de r\u00e9ussite avec leurs propres ovocytes, le recours \u00e0 des ovocytes de donneuse augmente significativement les chances de naissance vivante (Sunkara et al., 2011\u00a0; Kushnir et al., 2015). Un cycle en tandem permet de combiner ces options, permettant aux femmes de poursuivre le traitement avec leurs propres gam\u00e8tes tout en optimisant leurs chances de grossesse au cours d'un seul cycle.\n<\/p>\n\n\n\n

\n Les traitements de fertilit\u00e9 ne sont plus universels. Au Centre de FIV de Chypre du Nord, le Dr Savas Ozyigit et son \u00e9quipe adaptent les approches de rajeunissement \u00e0 votre biologie et \u00e0 vos objectifs. Qu'il s'agisse de r\u00e9activer vos ovaires gr\u00e2ce au PRP, d'optimiser la qualit\u00e9 des ovules gr\u00e2ce \u00e0 la th\u00e9rapie mitochondriale ou d'ajouter une couche de s\u00e9curit\u00e9 gr\u00e2ce \u00e0 un cycle de FIV en tandem, ces traitements innovants r\u00e9volutionnent les possibilit\u00e9s de reproduction.\n<\/p>\n\n\n\n

\n La science rencontre l\u2019espoir, et l\u2019espoir donne des r\u00e9sultats !\n<\/p>\n\n\n\n

\n
\n Dr Ahmet Ozyigit\n<\/p>","protected":false},"excerpt":{"rendered":"

L'hormone antim\u00fcll\u00e9rienne (AMH) est produite par les petits follicules des ovaires. C'est l'un des marqueurs les plus fiables de la r\u00e9serve ovarienne, qui repr\u00e9sente le nombre d'ovules restant dans les ovaires. Contrairement aux autres hormones de la reproduction, l'AMH est s\u00e9cr\u00e9t\u00e9e localement par les cellules de la granulosa des follicules pr\u00e9antraux et antraux. Sa production [\u2026]<\/p>","protected":false},"author":2,"featured_media":19251,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[114,113,55],"tags":[],"class_list":["post-19250","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40-ivf-treatment","category-egg-donation","category-ivf-treatment"],"yoast_head":"\nLow AMH level: Is it still possible to use my own eggs in an IVF cycle? - North Cyprus IVF<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lowcostivf.net\/fr\/latest-news-from-north-cyprus-ivf-center\/low-amh-level-is-it-still-possible-to-use-my-own-eggs-in-an-ivf-cycle\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Low AMH level: Is it still possible to use my own eggs in an IVF cycle? - North Cyprus IVF\" \/>\n<meta property=\"og:description\" content=\"Anti-M\u00fcllerian Hormone (AMH) is produced by the small follicles in a woman\u2019s ovaries and is one of the most reliable markers of ovarian reserve, which represents the number of eggs that remain in the ovaries. Unlike other reproductive hormones, AMH is secreted locally by the granulosa cells of pre-antral and small antral follicles. Its production […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.lowcostivf.net\/fr\/latest-news-from-north-cyprus-ivf-center\/low-amh-level-is-it-still-possible-to-use-my-own-eggs-in-an-ivf-cycle\/\" \/>\n<meta property=\"og:site_name\" content=\"North Cyprus IVF\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/northcyprusivf\/\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/northcyprusivf\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-08-17T16:10:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-17T16:11:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2025\/08\/eggs-IVF-cycle.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"809\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Asst. 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