{"id":3615,"date":"2020-01-15T14:01:34","date_gmt":"2020-01-15T14:01:34","guid":{"rendered":"https:\/\/www.lowcostivf.net\/?p=3615"},"modified":"2020-03-22T22:58:31","modified_gmt":"2020-03-22T22:58:31","slug":"stem-cell-therapy-for-patients-suffering-from-non-obstructive-azoospermia","status":"publish","type":"post","link":"https:\/\/www.lowcostivf.net\/de\/latest-news-from-north-cyprus-ivf-center\/stem-cell-therapy-for-patients-suffering-from-non-obstructive-azoospermia\/","title":{"rendered":"Stammzelltherapie f\u00fcr Patienten mit nicht-obstruktiver Azoospermie"},"content":{"rendered":"

Stammzelltherapie zur Spermienproduktion?<\/h2>\n\n\n\n

Nicht-obstruktive Azoospermie<\/strong> beinhaltet eine Gruppe von Problemen, die zu einem \u00e4hnlichen Ergebnis f\u00fchren: Mangelnde Spermienproduktion\/-reifung. Die Spermatogenese, ein Begriff, der die Summe aller Prozesse bezeichnet, die an der Produktion und Reifung einer Samenzelle beteiligt sind, besteht aus mehreren Schritten. Jede Fehlfunktion bei einem dieser Schritte kann zu Problemen bei der Gewinnung einer reifen Samenzelle im Ejakulat f\u00fchren. Diese Stadien k\u00f6nnen grob in Mitose (Anfertigung von Kopien der Keimzellen), Meiose 1, Meiose 2 und endg\u00fcltige Differenzierung eingeteilt werden. Der gesamte Prozess dauert etwa 65\u201370 Tage und f\u00fchrt zu einer reifen Samenzelle.
\u200b
F\u00fcr den Erfolg einer Stammzelltherapie ist es wichtig, in welchem Stadium die Spermienproduktion\/-reifung zum Stillstand kommt. Probleme bei der Spermienreifung k\u00f6nnten auf intrinsische Keimzelldefekte oder extrinsische somatische und\/oder endokrine Probleme zur\u00fcckzuf\u00fchren sein. Die Kenntnis des Unterschieds kann der Schl\u00fcssel zur genauen Identifizierung des Problems sein. Allerdings ist eine solche gezielte Therapie im menschlichen Modell derzeit nicht verf\u00fcgbar. Das folgende Bild hilft bei der Visualisierung des Spermatogeneseprozesses: <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Mitose ist das Stadium, in dem sich die Keimzelllinie vervielfacht und an Zahl zunimmt. Die Differenzierung erfolgt in den sp\u00e4teren Stadien. Wenn die Spermatogenese beispielsweise das Stadium erreichen kann, in dem sie zu Spermatiden f\u00fchrt, dann liegt das Hauptproblem in der endg\u00fcltigen Differenzierung in die Samenzelle, wie wir sie kennen. Dies ist wahrscheinlich einer der am besten geeigneten F\u00e4lle f\u00fcr eine Stammzelltherapie, da nur eine Phase im Prozess der Spermatogenese problematisch ist und die Wahrscheinlichkeit einer erfolgreichen L\u00f6sung des Problems h\u00f6her ist. <\/p>\n\n\n\n

Wenn sich das Problem in einem fr\u00fcheren Stadium befindet und noch keine unreifen Samenzellen produziert werden, wird die Aufgabe schwieriger. Je weiter unten im Prozess der Spermatogenese wir also auf Probleme sto\u00dfen, desto h\u00f6her sind die Erfolgsaussichten eines von uns eingesetzten Eingriffs.<\/p>\n\n\n\n

“Nur Sertoli-Zellen<\/strong>Das Syndrom bezieht sich auf einen Zustand, bei dem die Hodenstrukturen keine Keimzellen und nur Sertoli-Zellen aufweisen. Das Sertoli-Zell-Only-Syndrom kann angeboren oder erworben sein. Da beim kongenitalen Sertoli-Zell-Only-Syndrom keine Keimzellen vorhanden sind, stehen derzeit keine Behandlungsm\u00f6glichkeiten zur Verf\u00fcgung. Wenn die Erkrankung jedoch erworben wird (Klinefelter-Syndrom, Mumps, Strahlenbelastung, um nur einige zu nennen), kann die Erkrankung reversibel sein und eine Stammzelltherapie durchgef\u00fchrt werden.<\/p>\n\n\n\n

Im Rahmen der Stammzelltherapie bei IVF in Nordzypern<\/a>Wir isolieren Stammzellen aus dem eigenen Fettgewebe des Patienten, die durch eine Fettabsaugung am Bauch gewonnen werden. Hierbei handelt es sich um einen kleinen chirurgischen Eingriff, der von einem Chirurgen durchgef\u00fchrt wird. Es gelten die \u00fcblichen chirurgischen Verfahren, was bedeutet, dass ab einem bestimmten Zeitpunkt vor der Operation eine Einschr\u00e4nkung des Essens und Trinkens eingehalten werden muss. Dar\u00fcber hinaus f\u00fchren wir eine Reihe von Tests durch, um die Eignung f\u00fcr eine Operation zu best\u00e4tigen. Dabei handelt es sich eher um Standardverfahren.<\/p>\n\n\n\n

Durch die Fettabsaugung gewonnenes Fettgewebe wird dann einer enzymatischen Dissoziation und mehreren anderen Verfahren unterzogen, damit die Stammzellen erfolgreich isoliert werden k\u00f6nnen. In der Zwischenzeit wird auch das pl\u00e4ttchenreiche Plasma (PRP) des Patienten, das aus peripheren Blutproben gewonnen werden soll, separat isoliert. Nachdem die Stammzellen dem Kulturmedium und der Aussaat ausgesetzt wurden und alle Verfahren durchgef\u00fchrt wurden, wird die Kombination aus PRP und Stammzellpopulation an verschiedenen Stellen in die Hoden injiziert.<\/p>\n\n\n\n

Nach dem Eingriff werden Sie je nach Genesungsverlauf entweder am selben oder am n\u00e4chsten Tag aus dem Krankenhaus entlassen. Drei Monate nach der Stammzelltherapie ist eine Samenanalyse erforderlich, um die Auswirkungen festzustellen. Bei Patienten mit intakter Spermatogenese und Problemen in sp\u00e4teren Stadien erwarten wir etwa drei Monate nach dem Eingriff die Beobachtung lebender Spermien im Ejakulat. Wenn wir im Ejakulat keine lebenden Samenzellen finden, ist ein TESE\/TESA-Verfahren geplant, um nach reifenden Samenzellen zu suchen, die f\u00fcr die Befruchtung verwendet werden k\u00f6nnen. Die gesamte Behandlung dauert ca. 2-3 Tage (Voruntersuchung, Eingriff und Erholungszeit). Das bedeutet, dass Sie insgesamt nur 2-3 Tage auf Zypern bleiben m\u00fcssen. <\/p>\n\n\n\n

Was kostet eine Stammzelltherapie bei Azoospermie?<\/h2>\n\n\n\n

Die Kosten f\u00fcr diesen Eingriff betragen 6.000 Euro. Darin sind die Voruntersuchungen vor der Operation, s\u00e4mtliche Laborarbeiten und die Injektion der Stammzellen sowie der Aufenthalt im Krankenhaus f\u00fcr eine Nacht enthalten. Die vor der Planung Ihrer Behandlung erforderlichen Tests werden idealerweise in Ihrem Heimatland durchgef\u00fchrt und sind nicht in dieser Geb\u00fchr enthalten.<\/p>\n\n\n\n

Weitere Informationen finden Sie auf unserer \u201eStammzelltherapie bei nicht-obstruktiver Azoospermie<\/a>" Buchseite.<\/p>\n\n\n\n

Bitte Kontaktieren Sie unsere Patientenkoordinatoren<\/a> f\u00fcr mehr Informationen! <\/p>","protected":false},"excerpt":{"rendered":"

Stammzellentherapie zur Spermienproduktion? Nicht-obstruktive Azoospermie beinhaltet eine Reihe von Problemen, die zu einem \u00e4hnlichen Ergebnis f\u00fchren: Fehlende Spermienproduktion\/-reifung. Die Spermatogenese, ein Begriff, der f\u00fcr die Gesamtheit aller Prozesse verwendet wird, die an der Produktion und Reifung einer Samenzelle beteiligt sind, besteht aus mehreren Schritten. Jede Fehlfunktion w\u00e4hrend eines dieser Schritte [\u2026]<\/p>","protected":false},"author":2,"featured_media":3617,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[124],"tags":[126,125,123],"class_list":["post-3615","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-stem-cell-therapy","tag-stem-cell-for-nonobstructive-azoospermia","tag-stem-cell-sperm-2020","tag-stem-cell-therapy-for-azoospermia"],"yoast_head":"\nStem Cell Therapy for Patients With Non-Obstructive Azoospermia<\/title>\n<meta name=\"description\" content=\"Stem cells can be used in sertoli cell only syndrome if the condition is acquired rather than congenital. 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