{"id":719,"date":"2019-10-27T11:29:28","date_gmt":"2019-10-27T11:29:28","guid":{"rendered":"https:\/\/www.lowcostivf.net\/miscarriages\/"},"modified":"2024-12-09T18:00:10","modified_gmt":"2024-12-09T18:00:10","slug":"miscarriages","status":"publish","type":"page","link":"http:\/\/www.lowcostivf.net\/tr\/miscarriages\/","title":{"rendered":"D\u00fc\u015f\u00fckler"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"719\" class=\"elementor elementor-719\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0b98794 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0b98794\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-af92a17\" data-id=\"af92a17\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f4cc6f6 elementor-widget elementor-widget-jnews_element_header_elementor\" data-id=\"f4cc6f6\" data-element_type=\"widget\" data-widget_type=\"jnews_element_header_elementor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg_block_heading jeg_block_heading_5 jeg_aligncenter jnews_module__0_6a07b2271777b\">\n                <h3 class=\"jeg_block_title\"><span>Tekrarlayan (Tekrarlayan) D\u00fc\u015f\u00fckler ve Tedavi Se\u00e7enekleri<\/span><\/h3>\n                <style>.jnews_module__0_6a07b2271777b.jeg_block_heading_5 .jeg_block_title span, .jnews_module__0_6a07b2271777b.jeg_block_heading_5 .jeg_block_title i { color: #7a7a7a; }<\/style>\n            <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bf974d1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bf974d1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-396cfb4\" data-id=\"396cfb4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fb66b83 elementor-widget elementor-widget-image\" data-id=\"fb66b83\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"384\" src=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Miscarriages-768x384.jpg\" class=\"attachment-medium_large size-medium_large wp-image-1439\" alt=\"\" srcset=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Miscarriages-768x384.jpg 768w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Miscarriages-300x150.jpg 300w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Miscarriages-1024x512.jpg 1024w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Miscarriages-360x180.jpg 360w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Miscarriages-750x375.jpg 750w, https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Miscarriages.jpg 1140w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-26c6b13\" data-id=\"26c6b13\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-408ebc0 related_topics elementor-widget elementor-widget-text-editor\" data-id=\"408ebc0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"color: white !important;\">\u0130lgili konular<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-783fb7f elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"783fb7f\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/pre-implantation-genetic-diagnosis-pgd\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">\u0130mplantasyon \u00d6ncesi Genetik Tarama<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-714efd0 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"714efd0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/ivf-failures\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Tekrarlanan T\u00fcp Bebek Ba\u015far\u0131s\u0131zl\u0131klar\u0131<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3800402 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"3800402\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/advanced-sperm-selection\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Mikroak\u0131\u015fkan \u00e7ip ile sperm se\u00e7imi<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b339d00 elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"b339d00\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/ivf-for-women-over-40\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">40 ya\u015f \u00fcst\u00fc t\u00fcp bebek<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aadaaaf elementor-align-justify elementor-button-info elementor-widget elementor-widget-button\" data-id=\"aadaaaf\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/tr\/ivf-with-donor-eggs1\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-double-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Don\u00f6r Yumurtalarla T\u00fcp Bebek<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-60e431eb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"60e431eb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-df7a9fd\" data-id=\"df7a9fd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1b5f0ee5 elementor-widget elementor-widget-text-editor\" data-id=\"1b5f0ee5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Bir gebeli\u011fin kayb\u0131 \u00e7iftler i\u00e7in \u00e7ok travmatik bir deneyim olabilir. \u00c7al\u0131\u015fmalar, gebelik kayb\u0131 ya\u015fayan kad\u0131nlar\u0131n be\u015fte birinden fazlas\u0131n\u0131n kayg\u0131 ve depresyon belirtileri g\u00f6sterdi\u011fini g\u00f6stermektedir. Tek bir gebelik kayb\u0131n\u0131n bu kadar travmatik etkileri olabilirken, tekrarlayan gebelik kayb\u0131 (RPL) y\u0131k\u0131c\u0131 psikolojik etkilere sahip olabilir.<br><br>Tekrarlayan d\u00fc\u015f\u00fck, tekrarlayan gebelik kayb\u0131 olarak da bilinir ve genellikle 20. gebelik haftas\u0131ndan \u00f6nce iki veya daha fazla ard\u0131\u015f\u0131k gebelik kayb\u0131n\u0131n meydana gelmesi olarak tan\u0131mlan\u0131r. Bu olgu \u00fcreme \u00e7a\u011f\u0131ndaki kad\u0131nlar\u0131n yakla\u015f\u0131k 1-2%&#039;sini etkiler ve \u00f6nemli fiziksel ve duygusal sonu\u00e7lar ta\u015f\u0131r (Amerikan \u00dcreme T\u0131bb\u0131 Derne\u011fi Uygulama Komitesi, 2012). Genellikle rastgele kromozomal anormalliklere ba\u011flanan izole d\u00fc\u015f\u00fcklerin aksine, tekrarlayan d\u00fc\u015f\u00fckler altta yatan patolojilerden kaynaklanma olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir. Ele al\u0131nmas\u0131 gereken ilk \u015feylerden biri hastan\u0131n d\u00fc\u015f\u00fcklerini ya\u015fad\u0131\u011f\u0131 zamand\u0131r. Farkl\u0131 gebelik d\u00f6nemlerinde ya\u015fanan d\u00fc\u015f\u00fckler farkl\u0131 fakt\u00f6rleri g\u00f6sterebilir. Bu nedenleri anlamak, etkilenen \u00e7iftler i\u00e7in etkili y\u00f6netim ve deste\u011fi y\u00f6nlendirmeye yard\u0131mc\u0131 olur.<br><br>Tekrarlayan gebelik kay\u0131plar\u0131na ba\u011flanabilen bir dizi yerle\u015fik fakt\u00f6r olmas\u0131na ra\u011fmen, tekrarlayan gebeliklerin neredeyse yar\u0131s\u0131n\u0131n nedenleri hala bir gizem olarak kalmaktad\u0131r. Otoimm\u00fcn fakt\u00f6rler, hormonal sorunlar ve kan p\u0131ht\u0131la\u015fma sorunlar\u0131 birlikte bilinen t\u00fcm nedenlerin neredeyse 70%&#039;sini olu\u015fturmaktad\u0131r. Bu nedenle, bir kad\u0131n bir dizi d\u00fc\u015f\u00fck ya\u015fad\u0131\u011f\u0131nda, test i\u00e7in ba\u015flang\u0131\u00e7 noktas\u0131 genellikle bu \u00fc\u00e7 alandan birini i\u00e7erir.<br><br><\/p>\n<h2>Ard\u0131\u015f\u0131k D\u00fc\u015f\u00fcklerin Arkas\u0131ndaki Nedenler<\/h2>\n<p><a> <img decoding=\"async\" style=\"width: auto; max-width: 100%;\" src=\"https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/10\/what-are-the-causes-of-recurrent-miscarriages.png\" alt=\"Tekrarlayan d\u00fc\u015f\u00fcklerin ve gebelik kay\u0131plar\u0131n\u0131n nedenleri\"><\/a><\/p>\n<p>A\u015fa\u011f\u0131daki nedenlerin (belirli bir s\u0131raya g\u00f6re de\u011fil) tekrarlayan gebelik kay\u0131plar\u0131nda rol oynad\u0131\u011f\u0131 bilinmektedir:<\/p>\n<h4>1<u>Genetik Fakt\u00f6r<\/u><\/h4>\n<p>T\u00fcm d\u00fc\u015f\u00fcklerin %2-5&#039;ini genetik nedenler olu\u015fturur. Genetik nedenler aras\u0131nda kromozomal anormallikler, d\u00fc\u015f\u00fcklerin \u00f6nde gelen genetik nedenidir ve genetik nedenlerle olu\u015fan erken gebelik kay\u0131plar\u0131n\u0131n yakla\u015f\u0131k -60%&#039;sini olu\u015fturur. Bu anormallikler hem say\u0131sal hem de yap\u0131sal kromozomal kusurlar\u0131 i\u00e7erir.<br><br><u><b>A. Aneuploidi<\/b><\/u><br><br>Aneuploidi, anormal say\u0131da kromozom, d\u00fc\u015f\u00fcklerin en yayg\u0131n nedenlerinden biridir. Trizomi (fazladan bir kromozomun varl\u0131\u011f\u0131), \u00f6zellikle 16, 21 ve 22 numaral\u0131 kromozomlar\u0131n trizomileri olmak \u00fczere en s\u0131k g\u00f6r\u00fclen aneuploididir. Monozomi X (Turner sendromu) de d\u00fc\u015f\u00fckler aras\u0131nda yayg\u0131nd\u0131r ancak ilk trimesterden sonra nadiren ya\u015fayabilir (Hassold &amp; Hunt, 2001). Aneuploidiler genellikle gametlerde h\u00fccre b\u00f6l\u00fcnmesi s\u0131ras\u0131nda kromozomlar\u0131n do\u011fru \u015fekilde ayr\u0131lmamas\u0131 ve anormal kromozomal i\u00e7eri\u011fe sahip embriyolara yol a\u00e7an bir s\u00fcre\u00e7 olan meiotik nondisjunction nedeniyle olu\u015fur (Nagaoka ve ark., 2012).<br><br>B. <b>Yap\u0131sal Kromozomal Anormallikler<\/b><\/p>\n<p>Translokasyonlar, inversiyonlar ve delesyonlar gibi yap\u0131sal kromozomal anormallikler de tekrarlayan d\u00fc\u015f\u00fcklere katk\u0131da bulunur. Translokasyonlar, kromozom segmentleri homolog olmayan kromozomlar aras\u0131nda yeniden d\u00fczenlendi\u011finde meydana gelir. Net bir genetik materyal kazan\u0131m\u0131 veya kayb\u0131yla sonu\u00e7lanmayan dengeli translokasyonlar bireyi etkilemeyebilir ancak yeniden d\u00fczenlenen kromozomlar embriyo geli\u015fimini bozarsa d\u00fc\u015f\u00fcklere yol a\u00e7abilir (Stephenson ve ark., 2002). Ebeveyn karyotip analizi, tekrarlayan gebelik kayb\u0131 olan \u00e7iftlerde s\u0131kl\u0131kla yap\u0131sal anormallikleri ortaya \u00e7\u0131karabilir.<br><br>C. <b>Genetik Sendromlar ve Tek Gen Mutasyonlar\u0131<\/b><\/p>\n<p>Kromozomal anormallikler \u00f6nemli olmakla birlikte, tek gen mutasyonlar\u0131 veya genetik sendromlar da d\u00fc\u015f\u00fck riskini art\u0131rabilir.<br><br>C1. <b>Kal\u0131tsal Genetik Sendromlar<\/b><\/p>\n<p>Otozomal resesif veya otozomal dominant sendromlar dahil olmak \u00fczere kal\u0131tsal genetik durumlar gebelik kayb\u0131na katk\u0131da bulunabilir. \u00d6rne\u011fin, Blepharophimosis-Ptosis-Epicanthus Inversus sendromuyla ili\u015fkili FOXL2 genindeki mutasyonlar, d\u00fc\u015f\u00fck riskini art\u0131rarak yumurtal\u0131k disfonksiyonuna yol a\u00e7abilir (Crisponi ve di\u011ferleri, 2001).<br><br>C2. <b>Trombofili ile \u0130li\u015fkili Gen Mutasyonlar\u0131<\/b><\/p>\n<p>Trombofili veya kan p\u0131ht\u0131la\u015fmas\u0131nda art\u0131\u015fa neden olan belirli gen mutasyonlar\u0131 d\u00fc\u015f\u00fcklerle ili\u015fkilendirilmi\u015ftir. F5 (Fakt\u00f6r V Leiden) ve F2 (protrombin) gibi genlerdeki mutasyonlar plasentada anormal kan p\u0131ht\u0131la\u015fmas\u0131na yol a\u00e7arak kan ak\u0131\u015f\u0131n\u0131 bozabilir ve sonu\u00e7ta d\u00fc\u015f\u00fckle sonu\u00e7lanabilir (Rey ve ark., 2003). Trombofili \u00e7ok fakt\u00f6rl\u00fc bir durum olmas\u0131na ra\u011fmen, genetik yatk\u0131nl\u0131k baz\u0131 tekrarlayan gebelik kay\u0131plar\u0131nda katk\u0131da bulunan bir fakt\u00f6rd\u00fcr.<br><br>D. <b>Epigenetik Fakt\u00f6rler ve Ebeveyn Ya\u015f\u0131<\/b><\/p>\n<p>Epigenetik de\u011fi\u015fiklikler, DNA dizisinde de\u011fi\u015fiklik i\u00e7ermeyen gen ifadesindeki kal\u0131tsal de\u011fi\u015fiklikler de d\u00fc\u015f\u00fck riskine katk\u0131da bulunur. \u00d6rne\u011fin, DNA metilasyon hatalar\u0131 embriyo i\u00e7indeki gen ifadesini bozabilir ve bu da geli\u015fimsel durmaya ve d\u00fc\u015f\u00fcklere yol a\u00e7abilir.<br><br>D1. <b>Ebeveyn Ya\u015f\u0131<\/b><\/p>\n<p>\u0130leri anne ve baba ya\u015flar\u0131, \u00f6ncelikle zamanla germ h\u00fccrelerinde mutasyon birikimi nedeniyle artan genetik anormallik riskleriyle ili\u015fkilidir. 35 ya\u015f \u00fcst\u00fc kad\u0131nlar\u0131n kromozomal hatalara sahip oosit \u00fcretme riski daha y\u00fcksektir ve bu da d\u00fc\u015f\u00fcklere yol a\u00e7ar (Hassold &amp; Chiu, 1985). Benzer \u015fekilde, ileri baba ya\u015f\u0131, anormal embriyo geli\u015fimi nedeniyle d\u00fc\u015f\u00fck riskini art\u0131rabilen spermdeki DNA par\u00e7alanmas\u0131yla ili\u015fkilendirilmi\u015ftir (Kumar ve di\u011ferleri, 2012).<br><br>D2. <b>Bask\u0131lama Bozukluklar\u0131<\/b><\/p>\n<p>Belirli genlerin k\u00f6ken ebeveyne \u00f6zg\u00fc bir \u015fekilde ifade edildi\u011fi bask\u0131lama bozukluklar\u0131, d\u00fc\u015f\u00fck riskiyle ba\u011flant\u0131l\u0131d\u0131r. Bask\u0131lamadaki hatalar, d\u00fc\u015f\u00fcklere veya olumsuz gebelik sonu\u00e7lar\u0131na yol a\u00e7abilen Prader-Willi sendromu veya Angelman sendromu gibi bozukluklara yol a\u00e7abilir (Chong &amp; Hutchinson, 2000).<br><br>Genomik teknolojilerdeki ilerlemeler, d\u00fc\u015f\u00fcklerin genetik nedenlerinin anla\u015f\u0131lmas\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde art\u0131rm\u0131\u015ft\u0131r. Y\u00fcksek verimli dizileme, kromozomal mikrodizi analizi (CMA) ve implantasyon \u00f6ncesi genetik test (PGT), embriyolar\u0131n ve ebeveynlerin ayr\u0131nt\u0131l\u0131 kromozomal ve genetik analizine olanak tan\u0131r.<br><br>1. <b>Kromozomal Mikrodizi Analizi (CMA)<\/b><br>CMA, d\u00fc\u015f\u00fck dokusunda kromozomal anormallikleri tespit etmek i\u00e7in birincil test olarak bir\u00e7ok klinikte karyotiplemenin yerini alm\u0131\u015ft\u0131r. Bu teknoloji, geleneksel karyotiplemenin g\u00f6zden ka\u00e7\u0131rabilece\u011fi submikroskopik kromozomal dengesizlikleri tespit ederek a\u00e7\u0131klanamayan d\u00fc\u015f\u00fcklerin nedenlerine ili\u015fkin i\u00e7g\u00f6r\u00fc sa\u011flar (Reddy ve di\u011ferleri, 2012).<br><br>2. <b>Yeni Nesil Dizileme (NGS)<\/b><br>NGS, d\u00fc\u015f\u00fck yapmaya katk\u0131da bulunan tek gen mutasyonlar\u0131n\u0131n ve k\u00fc\u00e7\u00fck \u00f6l\u00e7ekli genetik anormalliklerin tan\u0131mlanmas\u0131n\u0131 kolayla\u015ft\u0131rm\u0131\u015ft\u0131r. Ayr\u0131ca erken gebelik kayb\u0131yla ili\u015fkili yeni genlerin ke\u015ffedilmesine yard\u0131mc\u0131 olmu\u015f ve genetik nedenlere ili\u015fkin daha fazla i\u00e7g\u00f6r\u00fc sa\u011flam\u0131\u015ft\u0131r (Xu ve di\u011ferleri, 2020). Hastalar \u00e7oklu gebelik kayb\u0131 ya\u015fad\u0131klar\u0131nda, NGS testi i\u00e7eren bir IVF d\u00f6ng\u00fcs\u00fc \u00e7ok etkili bir ara\u00e7 haline gelir. Bu yaln\u0131zca tekrarlayan d\u00fc\u015f\u00fckler i\u00e7in yap\u0131lmaz, ayn\u0131 zamanda tekrarlayan IVF ba\u015far\u0131s\u0131zl\u0131klar\u0131 i\u00e7in de etkili bir ara\u00e7t\u0131r.<br><br><\/p>\n<h4>2. Anatomik Anormallikler<\/h4>\n<p>\u00dcreme yolundaki yap\u0131sal anomaliler implantasyonu bozabilir, normal fetal geli\u015fimi bozabilir veya plasenta yetersizli\u011fine yol a\u00e7abilir ve bunlar\u0131n hepsi istenmeyen bir d\u00fc\u015f\u00fck olay\u0131na katk\u0131da bulunabilir. Anatomik anormalliklerin t\u00fcm d\u00fc\u015f\u00fcklerin %&#039;sine katk\u0131da bulundu\u011fu tahmin edilmektedir. <br><br>\u2022 <b>Do\u011fu\u015ftan Rahim Anomalileri<\/b>: Septat, bikornuat veya unikornuat uterus gibi uterus malformasyonlar\u0131 d\u00fc\u015f\u00fck riskini art\u0131rabilir. Lifli bir septumun uterus bo\u015flu\u011funu b\u00f6ld\u00fc\u011f\u00fc septat uterus, \u00f6zellikle y\u00fcksek d\u00fc\u015f\u00fck oranlar\u0131yla ili\u015fkilidir. Septum, implante edilen embriyoya yeterli kan ak\u0131\u015f\u0131n\u0131 destekleyemeyebilir ve bu da plasenta yetersizli\u011fine ve gebelik kayb\u0131na yol a\u00e7abilir (Grimbizis ve ark., 2001). Septumun cerrahi olarak d\u00fczeltilmesinin gebelik sonu\u00e7lar\u0131n\u0131 iyile\u015ftirdi\u011fi g\u00f6sterilmi\u015ftir.<br><br>\u2022 <b>Edinilmi\u015f Rahim Anormallikleri<\/b>: Miyomlar (\u00f6zellikle uterus bo\u015flu\u011funu bozan submukozal miyomlar) ve intrauterin yap\u0131\u015f\u0131kl\u0131klar (genellikle \u00f6nceki ameliyatlar veya enfeksiyonlar sonucu olu\u015fan uterus i\u00e7indeki yara izi) gibi durumlar implantasyona veya fetal geli\u015fime m\u00fcdahale edebilir. Bu yap\u0131lar uterus bo\u015flu\u011funun \u015feklini bozabilir, alan\u0131 daraltabilir ve geli\u015fmekte olan embriyoya giden kan ak\u0131\u015f\u0131n\u0131 s\u0131n\u0131rlayabilir, b\u00f6ylece d\u00fc\u015f\u00fck riskini art\u0131rabilir (Saravelos ve di\u011ferleri, 2008).<br><br><\/p>\n<h4>3. Endokrin Bozukluklar\u0131 (Hormonal Sorunlar)<\/h4>\n<p>Endokrin anormallikleri, \u00f6ncelikle hormonal denge ve uterin al\u0131c\u0131l\u0131\u011f\u0131 \u00fczerindeki etkileri nedeniyle tekrarlayan gebelik kayb\u0131na iyi belgelenmi\u015f katk\u0131da bulunur. Hormonal sorunlar\u0131n tekrarlayan d\u00fc\u015f\u00fcklerin 15-20%&#039;sinde rol oynad\u0131\u011f\u0131 bilinmektedir. <br><br>\u2022 <b>Polikistik Over Sendromu (PKOS)<\/b>: PCOS, d\u00fczensiz yumurtlama, hiperandrojenizm ve ins\u00fclin direnci ile karakterize yayg\u0131n bir endokrin bozuklu\u011fudur. PCOS&#039;lu kad\u0131nlarda y\u00fcksek ins\u00fclin seviyeleri, zay\u0131f endometrial geli\u015fime yol a\u00e7abilir ve erken gebelik kayb\u0131na katk\u0131da bulunabilir (Boomsma ve ark., 2006). Dahas\u0131, PCOS ile ili\u015fkili hormonal dengesizlik luteal faz\u0131 (endometriyumun embriyo implantasyonuna haz\u0131rland\u0131\u011f\u0131 yumurtlamadan sonraki d\u00f6nem) bozabilir ve potansiyel olarak implantasyon i\u00e7in yetersiz bir uterus ortam\u0131na yol a\u00e7abilir.<br><br>\u2022 <b>Luteal Faz Defekti:<\/b> Yumurtlamadan sonra korpus luteum taraf\u0131ndan \u00fcretilen progesteron taraf\u0131ndan d\u00fczenlenen luteal faz, implantasyon ve erken embriyo deste\u011fi i\u00e7in optimum bir endometrial ortam\u0131n s\u00fcrd\u00fcr\u00fclmesi a\u00e7\u0131s\u0131ndan kritik \u00f6neme sahiptir. Luteal faz defekti olarak bilinen progesteron \u00fcretimindeki eksiklik, yetersiz endometrial haz\u0131rl\u0131\u011fa yol a\u00e7arak implantasyonu bozabilir ve d\u00fc\u015f\u00fck riskini art\u0131rabilir.<br><br>\u2022 <b>Tiroid Hastal\u0131klar\u0131<\/b>: Tiroid fonksiyonu gebeli\u011fin s\u00fcrd\u00fcr\u00fclmesinde \u00f6nemli bir rol oynar. Hipotiroidizm (az \u00e7al\u0131\u015fan tiroid), \u00f6zellikle fet\u00fcs\u00fcn anne tiroid hormonlar\u0131na g\u00fcvendi\u011fi ilk trimesterde fetal geli\u015fim i\u00e7in gerekli olan tiroid hormonlar\u0131n\u0131n yetersiz \u00fcretimine yol a\u00e7abilir. \u00d6tiroid kad\u0131nlarda bile (normal tiroid fonksiyonu), tiroid otoantikorlar\u0131n\u0131n, \u00f6zellikle tiroid peroksidaz (TPO) antikorlar\u0131n\u0131n varl\u0131\u011f\u0131, d\u00fc\u015f\u00fck riskinin 2-3 kat artmas\u0131yla ili\u015fkilidir (Thangaratinam ve ark., 2011). Bu antikorlar anne ba\u011f\u0131\u015f\u0131kl\u0131k sistemini etkileyerek uterus ortam\u0131n\u0131 bozabilir.<br><br><br><\/p>\n<h4>4. \u0130mm\u00fcnolojik Fakt\u00f6rler<\/h4>\n<p>Ba\u011f\u0131\u015f\u0131kl\u0131k sistemi, fet\u00fcs genetik olarak anneden farkl\u0131 oldu\u011fundan gebeli\u011fi desteklemek i\u00e7in uyum sa\u011flamal\u0131d\u0131r. Bu uyumdaki bozulmalar d\u00fc\u015f\u00fckle sonu\u00e7lanabilir.<br><br>\u2022 <b>Antifosfolipid Sendromu (APS)<\/b>: APS, lupus antikoag\u00fclan\u0131 ve antikardiyolipin antikorlar\u0131 gibi antifosfolipid antikorlar\u0131n\u0131n varl\u0131\u011f\u0131yla karakterize bir otoimm\u00fcn durumdur. Bu antikorlar, plasentadakiler de dahil olmak \u00fczere kan damarlar\u0131nda p\u0131ht\u0131 olu\u015fumu riskini art\u0131r\u0131r. Plasental p\u0131ht\u0131lar, fet\u00fcse oksijen ve besin iletimini azaltarak d\u00fc\u015f\u00fckle sonu\u00e7lan\u0131r. APS, tekrarlayan gebelik kayb\u0131n\u0131n iyi belgelenmi\u015f bir nedenidir ve y\u00f6netimi genellikle antikoag\u00fclasyon tedavisini i\u00e7erir (Rai ve ark., 2005).<br><br>\u2022 <b>Do\u011fal Katil (NK) H\u00fccre Anormallikleri<\/b>: NK h\u00fccreleri erken gebelikte rol oynar ve plasental geli\u015fime yard\u0131mc\u0131 olur. Y\u00fcksek NK h\u00fccresi seviyeleri veya anormal NK h\u00fccresi fonksiyonunun tekrarlayan d\u00fc\u015f\u00fcklere katk\u0131da bulundu\u011fu varsay\u0131lmaktad\u0131r, \u00e7\u00fcnk\u00fc a\u015f\u0131r\u0131 aktif NK h\u00fccreleri plasental h\u00fccrelere sald\u0131rabilir. Ancak, NK h\u00fccrelerinin d\u00fc\u015f\u00fckteki kesin rol\u00fc hala tart\u0131\u015f\u0131lmaktad\u0131r ve NK h\u00fccre mod\u00fclasyonunun gebelik sonu\u00e7lar\u0131n\u0131 iyile\u015ftirip iyile\u015ftirmedi\u011fine dair \u00e7eli\u015fkili kan\u0131tlar vard\u0131r (Quenby ve di\u011ferleri, 2009).<br><br><br><\/p>\n<h4>5. Trombofilik Bozukluklar<\/h4>\n<p>Kal\u0131tsal trombofililer, bireyleri anormal kan p\u0131ht\u0131la\u015fmas\u0131na yatk\u0131n hale getiren ve hamilelik s\u0131ras\u0131nda olumsuz etkilere yol a\u00e7abilen genetik durumlard\u0131r.<br><br>\u2022 <b>Fakt\u00f6r V Leiden Mutasyonu<\/b>: Bu mutasyon, \u00f6nemli bir antikoag\u00fclan olan aktive protein C&#039;ye kar\u015f\u0131 dirence yol a\u00e7arak hiperkoag\u00fclabilite durumuna neden olur. Gebelik s\u0131ras\u0131nda bu mutasyon plasenta trombozuna (plasentada p\u0131ht\u0131 olu\u015fumu) yol a\u00e7abilir, fetal oksijen ve besin tedarikini bozabilir ve \u00f6zellikle ikinci trimesterde d\u00fc\u015f\u00fckle sonu\u00e7lanabilir (Preston ve ark., 2002).<br><br>\u2022 <b>Protrombin Gen Mutasyonu<\/b>: Bu mutasyon ayn\u0131 zamanda hiperkoag\u00fclabilite durumunu te\u015fvik ederek plasenta kan p\u0131ht\u0131s\u0131 riskini art\u0131r\u0131r. Bu mutasyona sahip kad\u0131nlar\u0131n, \u00f6zellikle hamileli\u011fin son d\u00f6nemlerinde d\u00fc\u015f\u00fck yapma riski daha y\u00fcksektir.<br><br>\u2022 <b>Protein C ve S Eksiklikleri<\/b>: Protein C ve S do\u011fal antikoag\u00fclanlard\u0131r. Bu proteinlerdeki eksiklikler, plasentan\u0131n i\u015flevini tehlikeye atabilen p\u0131ht\u0131 olu\u015fumunun artmas\u0131na neden olur. Ancak, trombofililer ile erken d\u00fc\u015f\u00fckler aras\u0131ndaki ba\u011flant\u0131 tart\u0131\u015fmal\u0131 olmaya devam etmektedir ve baz\u0131 \u00e7al\u0131\u015fmalar bunlar\u0131n ge\u00e7 gebelik komplikasyonlar\u0131yla daha alakal\u0131 oldu\u011funu ileri s\u00fcrmektedir (Lockwood, 2002).<br><br><\/p>\n<h4>6. Ya\u015fam Tarz\u0131 ve \u00c7evresel Fakt\u00f6rler<\/h4>\n<p>Gebelik sonu\u00e7lar\u0131n\u0131 etkileyebilecek birka\u00e7 de\u011fi\u015ftirilebilir ya\u015fam tarz\u0131 fakt\u00f6r\u00fc vard\u0131r.<br><br>\u2022 <b>Sigara i\u00e7mek<\/b>: Sigara duman\u0131ndaki nikotin ve di\u011fer toksinler, rahim kan ak\u0131\u015f\u0131n\u0131 bozarak embriyo geli\u015fimini bozabilecek ve d\u00fc\u015f\u00fck riskini art\u0131rabilecek hipoksik (d\u00fc\u015f\u00fck oksijenli) bir ortam yarat\u0131r. Sigara i\u00e7mek, muhtemelen t\u00fct\u00fcnden kaynaklanan oksidatif stres nedeniyle embriyoda kromozomal anormallik riskinin daha y\u00fcksek olmas\u0131yla ili\u015fkilidir (Green ve di\u011ferleri, 2007).<br><br>\u2022 <b>Alkol ve Kafein Al\u0131m\u0131<\/b>: A\u015f\u0131r\u0131 alkol t\u00fcketimi, d\u00fc\u015f\u00fck yapmaya katk\u0131da bulunabilen fetal toksisite ile ili\u015fkilidir. Y\u00fcksek kafein al\u0131m\u0131 (genellikle g\u00fcnde 200-300 mg&#039;\u0131n \u00fczerinde) muhtemelen gebeli\u011fi destekleyen kardiyovask\u00fcler ve hormonal sistemler \u00fczerindeki etkilerinden dolay\u0131 d\u00fc\u015f\u00fck riskinin artmas\u0131yla ili\u015fkilendirilmi\u015ftir (Ford &amp; Schust, 2009).<br><br>\u2022 <b>Obezite<\/b>: Obezite, hormonal dengesizlikler, artan ins\u00fclin direnci ve kronik d\u00fc\u015f\u00fck dereceli inflamasyon nedeniyle daha y\u00fcksek d\u00fc\u015f\u00fck riskiyle ili\u015fkilidir. Obezite ayr\u0131ca ba\u015far\u0131l\u0131 implantasyon ve gebeli\u011fin s\u00fcrd\u00fcr\u00fclmesi i\u00e7in \u00e7ok \u00f6nemli olan endometriyal al\u0131c\u0131l\u0131\u011f\u0131 da bozabilir (Metwally ve ark., 2008).<br><br><\/p>\n<h4>7. Enfeksiyonlar<\/h4>\n<p>Baz\u0131 enfeksiyonlar, fetal dokulara zarar veren veya maternal-fetal aray\u00fcz\u00fc bozan inflamatuar tepkilere neden olarak d\u00fc\u015f\u00fck riskini art\u0131rabilir. Enfeksiy\u00f6z nedenlerin aktif fazda s\u0131kl\u0131kla gebelik kayb\u0131na neden olma olas\u0131l\u0131\u011f\u0131 y\u00fcksek olsa da, baz\u0131 enfeksiyonlar tekrarlayan d\u00fc\u015f\u00fckler i\u00e7in bir fakt\u00f6r olabilecek kronik sorunlara neden olabilir:<br><br>\u2022 <b>Chlamydia trachomatis ve Ureaplasma urealyticum<\/b>: Bu bakteriler, rahim i\u00e7 tabakas\u0131n\u0131n iltihab\u0131 olan kronik endometrite neden olabilir ve bu da implantasyonu bozabilir veya plasentan\u0131n i\u015flevini bozarak d\u00fc\u015f\u00fckle sonu\u00e7lanabilir. Bu bakterilerle kronik enfeksiyon, olumsuz gebelik sonu\u00e7lar\u0131yla ili\u015fkilendirilmi\u015ftir ancak bunlar\u0131 \u00f6zellikle tekrarlayan d\u00fc\u015f\u00fcklerle ili\u015fkilendiren kan\u0131tlar kar\u0131\u015f\u0131kt\u0131r (Baud ve ark., 2008).<br><br>\u2022 <b>Sitomegalovir\u00fcs (CMV)<\/b>: CMV, annenin hamilelik s\u0131ras\u0131nda enfekte olmas\u0131 durumunda fet\u00fcse ge\u00e7ebilen bir herpes vir\u00fcs\u00fcd\u00fcr. Fetal CMV enfeksiyonu, \u00f6zellikle enfeksiyon hamileli\u011fin erken d\u00f6neminde meydana geldi\u011finde geli\u015fimsel anormalliklere yol a\u00e7abilir ve d\u00fc\u015f\u00fck riskini art\u0131rabilir. Bu, enfeksiyonun aktif faz\u0131nda bir sorun olma olas\u0131l\u0131\u011f\u0131 y\u00fcksektir. <br><br><\/p>\n<h4>8. A\u00e7\u0131klanamayan Nedenler<\/h4>\n<p>Tekrarlayan d\u00fc\u015f\u00fcklerin yakla\u015f\u0131k yar\u0131s\u0131, kapsaml\u0131 de\u011ferlendirmelere ra\u011fmen a\u00e7\u0131klanamamaktad\u0131r. A\u00e7\u0131klanamayan tekrarlayan d\u00fc\u015f\u00fckler, mevcut tan\u0131 testlerinin tespit edemedi\u011fi ba\u011f\u0131\u015f\u0131kl\u0131k, genetik veya hormonal fonksiyondaki ince anormallikleri i\u00e7erebilir. Ek olarak, bir\u00e7ok vakada \u00e7ok fakt\u00f6rl\u00fc nedenler olas\u0131d\u0131r ve birden fazla sistemdeki k\u00fc\u00e7\u00fck anormallikler toplu olarak gebelik kayb\u0131na katk\u0131da bulunur (Coomarasamy ve ark., 2014). Baz\u0131 vakalarda, bilinen bir neden olmasa bile, belirli profilaktik \u00f6nlemler al\u0131nabilir ve bu \u00f6nlemlerle olumlu sonu\u00e7lar g\u00f6zlemliyoruz; bu da belirli sorunlar laboratuvarlarda g\u00f6r\u00fcnmese bile, yine de antikoag\u00fclan, kortikosteroidler, antibiyotikler ve di\u011fer profilaktik \u00f6nlemlere yan\u0131t verebileceklerini g\u00f6stermektedir.<br><br><br><b>Referanslar<\/b><br><br>\u2022 Baud, D., Regan, L. ve Greub, G. (2008). Olumsuz gebelik sonu\u00e7lar\u0131nda Klamidya ve Klamidya benzeri organizmalar\u0131n ortaya \u00e7\u0131kan rol\u00fc. Bula\u015f\u0131c\u0131 Hastal\u0131klar Hakk\u0131nda G\u00fcncel G\u00f6r\u00fc\u015f, 21(1), 70-76.<br>\u2022 Boomsma, CM, Fauser, BC ve Macklon, NS (2006). Polikistik over sendromlu kad\u0131nlarda gebelik komplikasyonlar\u0131. \u00dcreme T\u0131bb\u0131 Seminerleri, 24(1), 35-43.<br>\u2022 Chong, S. ve Hutchinson, W. (2000). Genomik bask\u0131n\u0131n geli\u015fim ve hastal\u0131ktaki rol\u00fc. Lancet, 355(9197), 2117\u20132122.<br>\u2022 Coomarasamy, A., ve di\u011ferleri (2014). PROMISE denemesi: tekrarlayan d\u00fc\u015f\u00fcklerde progesteronun etkileri. Sa\u011fl\u0131k Teknolojisi De\u011ferlendirmesi, 18(40), 1-70.<br>\u2022 Crisponi, L., Deiana, M., Loi, A., ve di\u011ferleri (2001). Varsay\u0131lan \u00e7atal ba\u015fl\u0131 transkripsiyon fakt\u00f6r\u00fc FOXL2, blefarofimozis\/ptozis\/epikantus inversus sendromunda mutasyona u\u011frar. Do\u011fa Geneti\u011fi, 27(2), 159\u2013166.<br>\u2022 Ford, HB ve Schust, DJ (2009). Tekrarlayan gebelik kayb\u0131: etyoloji, tan\u0131 ve tedavi. Kad\u0131n Hastal\u0131klar\u0131 ve Do\u011fum \u0130ncelemeleri, 2(2), 76-83.<br>\u2022 Grimbizis, GF, ve di\u011ferleri (2001). Uterin malformasyonlar\u0131 ve histeroskopik tedavi sonu\u00e7lar\u0131. \u0130nsan \u00dcreme G\u00fcncellemesi, 7(2), 161-174.<br>\u2022 Green, KA, ve di\u011ferleri (2007). Sigara ve d\u00fc\u015f\u00fck: sistematik bir inceleme. T\u00fct\u00fcn Kontrol\u00fc, 16(2), 120-124.<br>\u2022 Hassold, T., ve di\u011ferleri (2007). \u0130nsan aneuploidisinin k\u00f6keni. \u0130nsan Molek\u00fcler Geneti\u011fi, 16(R2), R203-R208.<br>\u2022 Kumar, N., Singh, AK ve Yadav, P. (2012). Erkek k\u0131s\u0131rl\u0131\u011f\u0131: Genetik y\u00f6nlere genel bak\u0131\u015f. Lisans\u00fcst\u00fc T\u0131p Dergisi, 58(3), 243\u2013249.<br>\u2022 Lockwood, CJ (2002). Endometrial kanaman\u0131n mekanizmalar\u0131. Menopoz, 9(6), 411-417.<br>\u2022 Metwally, M., ve di\u011ferleri (2008). Obezitenin kad\u0131n \u00fcreme fonksiyonu \u00fczerindeki etkisi. Obezite \u0130ncelemeleri, 9(5), 456-468.<br>\u2022 Nagaoka, SI, Hassold, TJ ve Hunt, PA (2012). \u0130nsan aneuploidisi: As\u0131rl\u0131k bir soruna ili\u015fkin mekanizmalar ve yeni bak\u0131\u015f a\u00e7\u0131lar\u0131. Nature Reviews Genetics, 13(7), 493\u2013504.<br>\u2022 Amerikan \u00dcreme T\u0131bb\u0131 Derne\u011fi Uygulama Komitesi. (2012). K\u0131s\u0131rl\u0131k ve tekrarlayan gebelik kayb\u0131 tan\u0131mlar\u0131. K\u0131s\u0131rl\u0131k ve K\u0131s\u0131rl\u0131k, 98(3), 1-2.<br>\u2022 Preston, FE, ve di\u011ferleri (2002). Trombofili olan kad\u0131nlarda artm\u0131\u015f fetal kay\u0131p. Lancet, 356(9225), 270-273.<br>\u2022 Quenby, S., ve di\u011ferleri (2009). Tekrarlayan d\u00fc\u015f\u00fckleri olan kad\u0131nlarda pre-implantasyon endometrial l\u00f6kositler. \u0130nsan \u00dcremesi, 14(8), 2386-2391.<br>\u2022 Rai, R., ve di\u011ferleri (2005). Tekrarlayan d\u00fc\u015f\u00fcklerde antifosfolipid antikorlar\u0131. \u0130nsan \u00dcremesi, 10(7), 1818-1823.<br>\u2022 Reddy, UM, Page, GP ve Saade, GR (2012). Fetal \u00f6l\u00fcm\u00fcn de\u011ferlendirilmesinde DNA mikrodizilerinin rol\u00fc. Amerikan Kad\u0131n Hastal\u0131klar\u0131 ve Do\u011fum Dergisi, 207(4), 279\u2013288.<br><br>\u2022 Rey, E., Kahn, SR, David, M. ve Shrier, I. (2003). Trombofilik bozukluklar ve fetal kay\u0131p: Bir meta-analiz. Lancet, 361(9361), 901\u2013908.<br>\u2022 Saravelos, SH, ve di\u011ferleri (2008). Uterin anomalilerinde gebelik kayb\u0131 \u00f6r\u00fcnt\u00fcs\u00fc. Reproductive BioMedicine Online, 17(1), 134-138.<br>\u2022 Stephenson, MD, Awartani, KA, &amp; Robinson, WP (2002). Tekrarlayan d\u00fc\u015f\u00fckleri olan \u00e7iftlerin d\u00fc\u015f\u00fcklerinin sitogenetik analizi: Bir vaka kontrol \u00e7al\u0131\u015fmas\u0131. \u0130nsan \u00dcremesi, 17(2), 446\u2013451.<br>\u2022 Thangaratinam, S., ve di\u011ferleri (2011). Tiroid otoantikorlar\u0131 ve d\u00fc\u015f\u00fck riski. British Medical Journal, 342, d2616.<br>\u2022 Xu, Y., Li, L., Zhang, H., ve di\u011ferleri (2020). Tekrarlayan gebelik kayb\u0131nda t\u00fcm ekzom dizilemesinin klinik uygulamas\u0131. Klinik T\u0131p Dergisi, 9(4), 1156.<br><br><\/p>\n<hr style=\"width: 100%;\">\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ceef858 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ceef858\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ef1cdfc\" data-id=\"ef1cdfc\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3341455 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3341455\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-e768507\" data-id=\"e768507\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5dbb101 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"5dbb101\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/female-infertility\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/female-infertility-350x250.jpg);\" role=\"img\" aria-label=\"kad\u0131n k\u0131s\u0131rl\u0131\u011f\u0131\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tKad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Kad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131n\u0131n Nedenleri ve Tedavisi<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Kad\u0131n K\u0131s\u0131rl\u0131\u011f\u0131<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-b55c6a0\" data-id=\"b55c6a0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68999a9 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"68999a9\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/male-infertility\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Male-Infertility-350x250.jpg);\" role=\"img\" aria-label=\"Erkek K\u0131s\u0131rl\u0131\u011f\u0131\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tErkek K\u0131s\u0131rl\u0131\u011f\u0131\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Erkek K\u0131s\u0131rl\u0131\u011f\u0131n\u0131n Nedenleri ve Tedavisi<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Erkek K\u0131s\u0131rl\u0131\u011f\u0131<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-bac534e\" data-id=\"bac534e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-03b7495 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"03b7495\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/testing\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Testing-350x250.jpg);\" role=\"img\" aria-label=\"Test yapmak\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tTest yapmak\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">K\u0131s\u0131rl\u0131k Testi ve Te\u015fhisi<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Test yapmak<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-baa7007 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"baa7007\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-0006248\" data-id=\"0006248\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8718249 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"8718249\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/treatment-decision\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/Treatment-Decision-350x250.jpg);\" role=\"img\" aria-label=\"Tedavi-Karar\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tTedavi Karar\u0131\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Do\u011fru Tedaviyi Se\u00e7mek<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Tedavi Karar\u0131<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-0ce0554\" data-id=\"0ce0554\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-88c2df4 elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"88c2df4\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/improving-fertility\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/improving-fertility-350x250.jpg);\" role=\"img\" aria-label=\"do\u011furganl\u0131\u011f\u0131n iyile\u015ftirilmesi\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tDo\u011furganl\u0131\u011f\u0131 Art\u0131rmak\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Do\u011furganl\u0131k seviyenizi nas\u0131l iyile\u015ftirirsiniz (Y\u00fckseltirsiniz)?<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">Do\u011furganl\u0131k<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-1dc52c9\" data-id=\"1dc52c9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-33e276f elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"33e276f\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"elementor-cta\" href=\"\/tr\/ivf-failures\/\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.lowcostivf.net\/wp-content\/uploads\/2019\/11\/ivf-failures-350x250.jpg);\" role=\"img\" aria-label=\"IVF ba\u015far\u0131s\u0131zl\u0131klar\u0131\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tT\u00fcp Bebek Ba\u015far\u0131s\u0131zl\u0131klar\u0131\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\t<p style=\"text-align: center; !important;\">Tekrarlanan T\u00fcp Bebek Ba\u015far\u0131s\u0131zl\u0131klar\u0131<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-ribbon elementor-ribbon-left\">\n\t\t\t\t<div class=\"elementor-ribbon-inner\">T\u00fcp Bebek Ba\u015far\u0131s\u0131zl\u0131klar\u0131<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Tekrarlayan (Tekrarlayan) D\u00fc\u015f\u00fckler ve Tedavi Se\u00e7enekleri \u0130lgili Konular \u0130mplantasyon \u00d6ncesi Genetik Tarama Tekrarlanan T\u00fcp Bebek Ba\u015far\u0131s\u0131zl\u0131klar\u0131 Mikroak\u0131\u015fkan \u00e7ip ile sperm se\u00e7imi 40 ya\u015f \u00fcst\u00fc t\u00fcp bebek Don\u00f6r Yumurtalar\u0131 ile T\u00fcp Bebek Gebelik kayb\u0131 \u00e7iftler i\u00e7in olduk\u00e7a travmatik bir deneyim olabilir. Ara\u015ft\u0131rmalar, hamilelik kayb\u0131 ya\u015fayan kad\u0131nlar\u0131n be\u015fte birinden fazlas\u0131n\u0131n [\u2026]<\/p>","protected":false},"author":1,"featured_media":1439,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-719","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Miscarriages - North Cyprus IVF<\/title>\n<meta name=\"description\" content=\"Repeated miscarriages refer to recurring consecutive pregnancy losses. 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